ENSG00000139746

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267229 ENSG00000139746 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM26 protein_coding protein_coding 34.38694 15.23981 48.39433 0.8270085 0.4123526 1.666345 7.3105526 3.0369445 11.418776 0.61370703 1.0018716 1.9072358 0.20188750 0.19783333 0.23616667 0.038333333 7.271307e-01 2.548713e-37 FALSE TRUE
ENST00000438724 ENSG00000139746 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM26 protein_coding protein_coding 34.38694 15.23981 48.39433 0.8270085 0.4123526 1.666345 3.2178680 1.1776889 4.128378 0.10614119 0.2441830 1.8009082 0.09276667 0.07830000 0.08523333 0.006933333 8.506975e-01 2.548713e-37 FALSE TRUE
ENST00000449987 ENSG00000139746 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM26 protein_coding protein_coding 34.38694 15.23981 48.39433 0.8270085 0.4123526 1.666345 3.9930070 4.7579836 3.425311 0.57735123 0.8448290 -0.4729387 0.17932917 0.31273333 0.07103333 -0.241700000 1.089428e-05 2.548713e-37 FALSE TRUE
MSTRG.8946.1 ENSG00000139746 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM26 protein_coding   34.38694 15.23981 48.39433 0.8270085 0.4123526 1.666345 4.1781336 0.0000000 6.979638 0.00000000 0.9770105 9.4490739 0.08060833 0.00000000 0.14390000 0.143900000 6.513809e-20 2.548713e-37 FALSE TRUE
MSTRG.8946.22 ENSG00000139746 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM26 protein_coding   34.38694 15.23981 48.39433 0.8270085 0.4123526 1.666345 2.8545579 1.7664085 1.996241 0.27782733 1.1396527 0.1755312 0.08995833 0.11466667 0.04086667 -0.073800000 5.166334e-01 2.548713e-37 TRUE TRUE
MSTRG.8946.25 ENSG00000139746 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM26 protein_coding   34.38694 15.23981 48.39433 0.8270085 0.4123526 1.666345 0.6439337 1.4445490 0.000000 0.42704259 0.0000000 -7.1844281 0.04218750 0.09523333 0.00000000 -0.095233333 3.670674e-13 2.548713e-37 TRUE TRUE
MSTRG.8946.3 ENSG00000139746 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM26 protein_coding   34.38694 15.23981 48.39433 0.8270085 0.4123526 1.666345 2.5557117 0.0000000 7.071023 0.00000000 0.2298641 9.4678141 0.05317083 0.00000000 0.14616667 0.146166667 2.548713e-37 2.548713e-37 TRUE TRUE
MSTRG.8946.37 ENSG00000139746 HEK293_OSMI2_2hA HEK293_TMG_2hB RBM26 protein_coding   34.38694 15.23981 48.39433 0.8270085 0.4123526 1.666345 2.6710450 0.2542268 4.749723 0.04799089 0.1023851 4.1710289 0.06113750 0.01666667 0.09816667 0.081500000 8.641053e-14 2.548713e-37 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139746 E001 130.2810874 0.0433460137 1.325263e-04 6.699948e-04 13 79311824 79312197 374 - 1.892 2.348 1.528
ENSG00000139746 E002 147.7442231 0.0402533607 3.047908e-02 7.290527e-02 13 79312198 79312319 122 - 2.026 2.296 0.901
ENSG00000139746 E003 266.5572614 0.0255094319 5.358641e-02 1.155253e-01 13 79312320 79312799 480 - 2.308 2.499 0.636
ENSG00000139746 E004 147.8722129 0.0016906627 3.871636e-05 2.238987e-04 13 79312800 79313233 434 - 2.058 2.229 0.573
ENSG00000139746 E005 174.5419454 0.0082179841 2.178896e-01 3.478840e-01 13 79313234 79313606 373 - 2.190 2.145 -0.150
ENSG00000139746 E006 96.4461853 0.0005371667 4.657346e-02 1.030714e-01 13 79313607 79313789 183 - 1.942 1.870 -0.241
ENSG00000139746 E007 143.7045516 0.0008990910 8.439598e-07 7.122807e-06 13 79313790 79314177 388 - 2.133 1.953 -0.603
ENSG00000139746 E008 117.7619890 0.0011194586 5.812080e-07 5.079022e-06 13 79314178 79314551 374 - 2.051 1.844 -0.695
ENSG00000139746 E009 39.6797635 0.0012585481 2.980192e-08 3.356649e-07 13 79314552 79314552 1 - 1.618 1.187 -1.494
ENSG00000139746 E010 50.6581615 0.0004339663 6.903893e-06 4.761620e-05 13 79314553 79314606 54 - 1.703 1.425 -0.949
ENSG00000139746 E011 37.8131333 0.0005282760 5.509907e-03 1.731415e-02 13 79314607 79314613 7 - 1.565 1.383 -0.628
ENSG00000139746 E012 105.1973956 0.0003209601 8.809275e-03 2.580766e-02 13 79314614 79314735 122 - 1.982 1.888 -0.318
ENSG00000139746 E013 50.1199739 0.0004594387 2.578148e-01 3.949911e-01 13 79314736 79314737 2 - 1.657 1.606 -0.173
ENSG00000139746 E014 173.7835758 0.0005771358 6.966211e-01 7.969124e-01 13 79314738 79314990 253 - 2.169 2.199 0.099
ENSG00000139746 E015 52.3895781 0.0025043144 2.398219e-02 5.977154e-02 13 79314991 79314993 3 - 1.620 1.768 0.502
ENSG00000139746 E016 60.0206247 0.0053364868 5.020805e-01 6.381765e-01 13 79318821 79318867 47 - 1.705 1.763 0.198
ENSG00000139746 E017 42.8740742 0.0017949371 3.727894e-01 5.172108e-01 13 79318868 79318876 9 - 1.559 1.632 0.249
ENSG00000139746 E018 32.8107778 0.0016312741 1.230965e-01 2.243693e-01 13 79318877 79318879 3 - 1.433 1.556 0.423
ENSG00000139746 E019 50.0096393 0.0004884230 1.050574e-01 1.981709e-01 13 79318880 79319534 655 - 1.616 1.723 0.363
ENSG00000139746 E020 165.4889224 0.0064170421 2.607413e-09 3.579986e-08 13 79319535 79319953 419 - 2.061 2.367 1.023
ENSG00000139746 E021 442.2967050 0.0001498444 2.235457e-53 1.641475e-50 13 79319954 79320710 757 - 2.487 2.784 0.989
ENSG00000139746 E022 34.4748711 0.0144627234 4.398977e-01 5.816273e-01 13 79321234 79321301 68 - 1.459 1.546 0.298
ENSG00000139746 E023 17.7642055 0.0009860762 4.847803e-02 1.064696e-01 13 79322208 79322348 141 - 1.250 1.066 -0.658
ENSG00000139746 E024 264.0683447 0.0001786599 5.083502e-16 1.996795e-14 13 79322349 79322462 114 - 2.294 2.506 0.708
ENSG00000139746 E025 212.6331744 0.0004357099 3.020659e-11 5.815597e-10 13 79334344 79334430 87 - 2.202 2.405 0.677
ENSG00000139746 E026 1.4287079 0.0157272103 4.412597e-01 5.828911e-01 13 79334431 79334488 58 - 0.305 0.459 0.885
ENSG00000139746 E027 5.0690518 0.0367155242 3.267129e-03 1.105284e-02 13 79336456 79336535 80 - 0.819 0.211 -3.161
ENSG00000139746 E028 312.0724472 0.0012303803 7.000614e-07 6.011447e-06 13 79337102 79337302 201 - 2.387 2.540 0.510
ENSG00000139746 E029 236.9199468 0.0018606285 5.385558e-05 3.010113e-04 13 79341123 79341227 105 - 2.270 2.418 0.494
ENSG00000139746 E030 282.5469688 0.0002663451 3.033171e-05 1.802915e-04 13 79342664 79342831 168 - 2.352 2.471 0.396
ENSG00000139746 E031 204.6903985 0.0005163215 8.635503e-01 9.159916e-01 13 79344248 79344322 75 - 2.240 2.263 0.075
ENSG00000139746 E032 248.5599004 0.0002069043 3.075872e-01 4.498084e-01 13 79344669 79344794 126 - 2.320 2.364 0.145
ENSG00000139746 E033 23.0777542 0.0073312610 2.652351e-01 4.032679e-01 13 79353153 79353224 72 - 1.289 1.404 0.401
ENSG00000139746 E034 220.9671213 0.0013653540 9.539652e-01 9.751648e-01 13 79354439 79354561 123 - 2.278 2.293 0.049
ENSG00000139746 E035 77.2095748 0.0098304729 5.168129e-01 6.513291e-01 13 79354562 79354570 9 - 1.835 1.809 -0.087
ENSG00000139746 E036 235.6116866 0.0016533212 6.587978e-02 1.365088e-01 13 79355220 79355384 165 - 2.319 2.274 -0.152
ENSG00000139746 E037 193.4361845 0.0015740735 2.374231e-02 5.928364e-02 13 79358274 79358433 160 - 2.238 2.173 -0.218
ENSG00000139746 E038 180.1564553 0.0004682478 5.084239e-04 2.191318e-03 13 79359575 79359686 112 - 2.214 2.114 -0.336
ENSG00000139746 E039 233.4681852 0.0010231752 6.140701e-06 4.285010e-05 13 79365578 79365718 141 - 2.333 2.203 -0.435
ENSG00000139746 E040 13.7962174 0.0012670964 8.869012e-01 9.316785e-01 13 79365719 79365733 15 - 1.109 1.110 0.002
ENSG00000139746 E041 0.3030308 0.3661578903 1.000000e+00   13 79365760 79366054 295 - 0.127 0.001 -7.740
ENSG00000139746 E042 209.7450579 0.0002252794 1.577695e-08 1.873798e-07 13 79366055 79366195 141 - 2.292 2.132 -0.534
ENSG00000139746 E043 35.0965756 0.0006147655 7.125416e-02 1.454159e-01 13 79366196 79366225 30 - 1.519 1.405 -0.393
ENSG00000139746 E044 246.5553468 0.0038217544 1.197162e-05 7.812029e-05 13 79366633 79366872 240 - 2.362 2.199 -0.545
ENSG00000139746 E045 281.8033054 0.0002037495 1.323178e-13 3.698864e-12 13 79368730 79368990 261 - 2.425 2.240 -0.619
ENSG00000139746 E046 291.5347505 0.0001950864 2.070834e-17 9.698719e-16 13 79370945 79371159 215 - 2.444 2.230 -0.714
ENSG00000139746 E047 96.0060881 0.0003023251 1.794777e-09 2.536668e-08 13 79371160 79371162 3 - 1.975 1.702 -0.918
ENSG00000139746 E048 181.9424342 0.0002429315 2.914640e-12 6.630280e-11 13 79371842 79371930 89 - 2.242 2.018 -0.750
ENSG00000139746 E049 2.0607808 0.0111017861 5.569357e-01 6.854758e-01 13 79376217 79377378 1162 - 0.457 0.353 -0.573
ENSG00000139746 E050 190.1512772 0.0082881642 2.242310e-05 1.374309e-04 13 79377379 79377515 137 - 2.259 2.043 -0.725
ENSG00000139746 E051 186.7072849 0.0125002505 6.758482e-04 2.810735e-03 13 79378789 79378907 119 - 2.248 2.052 -0.657
ENSG00000139746 E052 124.1271390 0.0048691293 3.835289e-06 2.801882e-05 13 79405704 79405741 38 - 2.079 1.846 -0.785
ENSG00000139746 E053 153.1281318 0.0042997459 8.093925e-14 2.332476e-12 13 79405742 79406061 320 - 2.190 1.817 -1.253
ENSG00000139746 E054 118.1607642 0.0023895823 3.227915e-16 1.303600e-14 13 79406062 79406477 416 - 2.083 1.669 -1.396