ENSG00000139734

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377908 ENSG00000139734 HEK293_OSMI2_2hA HEK293_TMG_2hB DIAPH3 protein_coding protein_coding 11.50545 3.438468 20.46361 0.4144786 0.8312347 2.569738 3.0975637 0.009995101 6.68710 0.009995101 0.7007729 8.387746 0.1637458 0.002966667 0.3257333 0.3227667 7.986458e-19 7.986458e-19 FALSE TRUE
ENST00000400324 ENSG00000139734 HEK293_OSMI2_2hA HEK293_TMG_2hB DIAPH3 protein_coding protein_coding 11.50545 3.438468 20.46361 0.4144786 0.8312347 2.569738 7.3035616 2.524393935 13.16718 0.352741103 0.6815524 2.378329 0.7064792 0.747166667 0.6437667 -0.1034000 6.667646e-01 7.986458e-19 FALSE TRUE
ENST00000649952 ENSG00000139734 HEK293_OSMI2_2hA HEK293_TMG_2hB DIAPH3 protein_coding processed_transcript 11.50545 3.438468 20.46361 0.4144786 0.8312347 2.569738 0.3049899 0.824279184 0.00000 0.422397201 0.0000000 -6.382458 0.0733875 0.223600000 0.0000000 -0.2236000 3.345618e-02 7.986458e-19   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139734 E001 23.6172455 0.0660789799 4.650344e-03 1.495948e-02 13 59665583 59665691 109 - 1.143 1.613 1.633
ENSG00000139734 E002 203.2258490 0.0182845026 8.779023e-09 1.093608e-07 13 59665692 59666583 892 - 2.066 2.492 1.422
ENSG00000139734 E003 87.8004284 0.0003188145 3.993010e-02 9.090693e-02 13 59666584 59666740 157 - 1.775 1.914 0.469
ENSG00000139734 E004 90.5788181 0.0003274657 4.842451e-02 1.063725e-01 13 59666741 59666846 106 - 1.789 1.923 0.452
ENSG00000139734 E005 0.0000000       13 59695252 59695445 194 -      
ENSG00000139734 E006 0.4439371 0.0215908987 1.000000e+00 1.000000e+00 13 59696026 59696193 168 - 0.136 0.001 -6.896
ENSG00000139734 E007 0.0000000       13 59750839 59751021 183 -      
ENSG00000139734 E008 0.3268771 0.0284457568 1.788745e-01   13 59774059 59774162 104 - 0.050 0.270 2.809
ENSG00000139734 E009 0.4720498 0.1587016944 3.556260e-01 5.000021e-01 13 59774163 59774188 26 - 0.095 0.270 1.814
ENSG00000139734 E010 64.1927267 0.0004177527 1.367569e-01 2.435689e-01 13 59774189 59774248 60 - 1.645 1.769 0.420
ENSG00000139734 E011 87.5111264 0.0003828992 2.898638e-02 6.997897e-02 13 59774728 59774823 96 - 1.773 1.918 0.490
ENSG00000139734 E012 109.1893598 0.0002932833 2.187676e-01 3.489301e-01 13 59810788 59810923 136 - 1.876 1.969 0.315
ENSG00000139734 E013 117.5906962 0.0005805655 2.577724e-01 3.949475e-01 13 59833107 59833271 165 - 1.909 1.997 0.297
ENSG00000139734 E014 3.8288634 0.0576273855 9.509553e-02 1.830179e-01 13 59837675 59839323 1649 - 0.507 0.845 1.437
ENSG00000139734 E015 105.1180285 0.0002909439 6.702918e-01 7.767840e-01 13 59839324 59839448 125 - 1.865 1.923 0.195
ENSG00000139734 E016 0.4386386 0.1589773794 3.568625e-01 5.012570e-01 13 59861254 59861406 153 - 0.095 0.268 1.798
ENSG00000139734 E017 103.5061753 0.0002869423 6.165751e-01 7.346157e-01 13 59861407 59861536 130 - 1.867 1.881 0.045
ENSG00000139734 E018 128.4792689 0.0011495649 4.365682e-01 5.786425e-01 13 59879229 59879468 240 - 1.963 1.965 0.008
ENSG00000139734 E019 80.1497588 0.0013313168 9.236287e-01 9.558752e-01 13 59911735 59911836 102 - 1.756 1.788 0.107
ENSG00000139734 E020 75.5334770 0.0004668041 6.195248e-01 7.369112e-01 13 59916155 59916249 95 - 1.722 1.788 0.221
ENSG00000139734 E021 78.4655068 0.0016883693 7.188226e-01 8.138093e-01 13 59924775 59924870 96 - 1.746 1.763 0.060
ENSG00000139734 E022 83.7551548 0.0013012611 6.389608e-01 7.524754e-01 13 59969944 59970058 115 - 1.777 1.788 0.036
ENSG00000139734 E023 100.2497360 0.0005139309 7.291581e-01 8.213873e-01 13 59970852 59971160 309 - 1.846 1.900 0.183
ENSG00000139734 E024 72.6292448 0.0006669477 1.677393e-01 2.852552e-01 13 59974352 59974456 105 - 1.723 1.677 -0.157
ENSG00000139734 E025 75.2816484 0.0211967656 2.766778e-01 4.161502e-01 13 59980795 59980859 65 - 1.741 1.683 -0.199
ENSG00000139734 E026 94.5629798 0.0008774674 2.202886e-04 1.050707e-03 13 59983769 59983887 119 - 1.853 1.677 -0.596
ENSG00000139734 E027 85.3028530 0.0003254601 1.038236e-02 2.970081e-02 13 59991158 59991274 117 - 1.802 1.692 -0.370
ENSG00000139734 E028 85.7881538 0.0003118041 5.705096e-03 1.783079e-02 13 59992068 59992186 119 - 1.806 1.685 -0.410
ENSG00000139734 E029 70.1254566 0.0003464612 1.903939e-01 3.142522e-01 13 59992473 59992583 111 - 1.711 1.669 -0.143
ENSG00000139734 E030 62.1761534 0.0003680536 4.759721e-03 1.525977e-02 13 60008544 60008649 106 - 1.673 1.517 -0.533
ENSG00000139734 E031 78.3879030 0.0003397026 6.218592e-04 2.613108e-03 13 60010533 60010669 137 - 1.774 1.599 -0.591
ENSG00000139734 E032 0.0000000       13 60013049 60013209 161 -      
ENSG00000139734 E033 54.8016366 0.0004352739 9.393195e-06 6.283146e-05 13 60015913 60015982 70 - 1.635 1.318 -1.090
ENSG00000139734 E034 64.6791058 0.0003801423 3.233857e-06 2.402151e-05 13 60016071 60016145 75 - 1.704 1.400 -1.039
ENSG00000139734 E035 77.0336058 0.0008107347 2.103394e-05 1.297986e-04 13 60042690 60042820 131 - 1.771 1.528 -0.825
ENSG00000139734 E036 61.8532941 0.0004052798 1.082489e-01 2.029493e-01 13 60093628 60093732 105 - 1.658 1.590 -0.231
ENSG00000139734 E037 64.8174927 0.0003709288 4.827271e-02 1.061158e-01 13 60112010 60112186 177 - 1.681 1.590 -0.309
ENSG00000139734 E038 26.6176424 0.0007946574 4.574493e-03 1.474854e-02 13 60132957 60132989 33 - 1.328 1.055 -0.972
ENSG00000139734 E039 69.5619360 0.0003510276 1.433383e-03 5.418107e-03 13 60163587 60163928 342 - 1.721 1.550 -0.583