ENSG00000139697

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267176 ENSG00000139697 HEK293_OSMI2_2hA HEK293_TMG_2hB SBNO1 protein_coding protein_coding 7.834456 2.619175 10.54424 0.07610206 0.2819754 2.005141 1.1852149 1.072917304 1.2034626 0.290544806 0.6636387 0.1642066 0.22478333 0.406533333 0.11203333 -0.29450000 0.362291529 0.001903024 FALSE TRUE
ENST00000420886 ENSG00000139697 HEK293_OSMI2_2hA HEK293_TMG_2hB SBNO1 protein_coding protein_coding 7.834456 2.619175 10.54424 0.07610206 0.2819754 2.005141 1.1891224 1.310028731 0.6271857 0.352909551 0.6271857 -1.0507836 0.29927917 0.503033333 0.05700000 -0.44603333 0.046971069 0.001903024 FALSE TRUE
ENST00000602398 ENSG00000139697 HEK293_OSMI2_2hA HEK293_TMG_2hB SBNO1 protein_coding protein_coding 7.834456 2.619175 10.54424 0.07610206 0.2819754 2.005141 0.4144961 0.000000000 1.3740836 0.000000000 0.9133093 7.1127873 0.04958333 0.000000000 0.13516667 0.13516667 0.397051377 0.001903024 FALSE TRUE
MSTRG.8240.11 ENSG00000139697 HEK293_OSMI2_2hA HEK293_TMG_2hB SBNO1 protein_coding   7.834456 2.619175 10.54424 0.07610206 0.2819754 2.005141 0.4663777 0.003459823 0.9494415 0.003459823 0.3133056 6.1554635 0.03878750 0.001333333 0.09096667 0.08963333 0.001903024 0.001903024 FALSE TRUE
MSTRG.8240.12 ENSG00000139697 HEK293_OSMI2_2hA HEK293_TMG_2hB SBNO1 protein_coding   7.834456 2.619175 10.54424 0.07610206 0.2819754 2.005141 0.6871891 0.000000000 1.4049193 0.000000000 0.7039994 7.1445760 0.05257917 0.000000000 0.13360000 0.13360000 0.353225266 0.001903024 FALSE TRUE
MSTRG.8240.5 ENSG00000139697 HEK293_OSMI2_2hA HEK293_TMG_2hB SBNO1 protein_coding   7.834456 2.619175 10.54424 0.07610206 0.2819754 2.005141 2.1490080 0.222956997 2.9933433 0.105743914 0.7191641 3.6884338 0.18820417 0.085166667 0.28106667 0.19590000 0.131964151 0.001903024 TRUE TRUE
MSTRG.8240.6 ENSG00000139697 HEK293_OSMI2_2hA HEK293_TMG_2hB SBNO1 protein_coding   7.834456 2.619175 10.54424 0.07610206 0.2819754 2.005141 0.5228838 0.000000000 0.6951245 0.000000000 0.3501457 6.1398062 0.04049167 0.000000000 0.06730000 0.06730000 0.399928287 0.001903024 TRUE TRUE
MSTRG.8240.7 ENSG00000139697 HEK293_OSMI2_2hA HEK293_TMG_2hB SBNO1 protein_coding   7.834456 2.619175 10.54424 0.07610206 0.2819754 2.005141 0.7089126 0.000000000 1.0051090 0.000000000 1.0051090 6.6654909 0.05484583 0.000000000 0.09486667 0.09486667 1.000000000 0.001903024 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139697 E001 39.5200193 0.0293674091 6.429880e-15 2.180278e-13 12 123289109 123289334 226 - 1.102 2.013 3.129
ENSG00000139697 E002 50.1091057 0.0360325584 2.762563e-14 8.511291e-13 12 123289335 123289421 87 - 1.184 2.120 3.196
ENSG00000139697 E003 383.4296289 0.0146160316 1.144709e-14 3.733201e-13 12 123289422 123294432 5011 - 2.325 2.845 1.730
ENSG00000139697 E004 7.7953669 0.0034587878 9.084595e-03 2.649235e-02 12 123294433 123294461 29 - 0.946 0.668 -1.097
ENSG00000139697 E005 8.9254242 0.0021498115 4.034078e-02 9.165156e-02 12 123294462 123294507 46 - 0.979 0.812 -0.635
ENSG00000139697 E006 171.5475834 0.0008264874 1.019916e-15 3.844410e-14 12 123294508 123295594 1087 - 2.060 2.408 1.166
ENSG00000139697 E007 52.9310640 0.0008428935 4.914343e-01 6.286980e-01 12 123295595 123295690 96 - 1.629 1.775 0.494
ENSG00000139697 E008 47.5276914 0.0014745551 6.281486e-01 7.437716e-01 12 123295691 123295760 70 - 1.586 1.723 0.464
ENSG00000139697 E009 38.1901080 0.0020422077 4.318269e-01 5.743352e-01 12 123295761 123295806 46 - 1.488 1.646 0.541
ENSG00000139697 E010 47.0143992 0.0125194214 9.805634e-01 9.918193e-01 12 123295807 123295896 90 - 1.590 1.700 0.376
ENSG00000139697 E011 66.4841746 0.0020260078 1.627468e-01 2.787290e-01 12 123295897 123296050 154 - 1.760 1.797 0.125
ENSG00000139697 E012 76.9087669 0.0004565616 6.410245e-02 1.335285e-01 12 123297978 123298171 194 - 1.825 1.852 0.089
ENSG00000139697 E013 35.5488057 0.0031590311 7.618517e-01 8.456156e-01 12 123302824 123302900 77 - 1.480 1.568 0.300
ENSG00000139697 E014 47.2412721 0.0010363848 8.464759e-01 9.045964e-01 12 123304582 123304719 138 - 1.594 1.692 0.333
ENSG00000139697 E015 44.1851801 0.0018254813 1.221114e-01 2.229415e-01 12 123309310 123309402 93 - 1.590 1.603 0.043
ENSG00000139697 E016 44.8996636 0.0027413964 3.871972e-01 5.313381e-01 12 123309489 123309583 95 - 1.586 1.641 0.186
ENSG00000139697 E017 47.8329227 0.0005023140 9.038582e-01 9.428292e-01 12 123309710 123309856 147 - 1.600 1.702 0.348
ENSG00000139697 E018 35.8512485 0.0007539460 3.954259e-01 5.392357e-01 12 123311055 123311129 75 - 1.492 1.546 0.182
ENSG00000139697 E019 34.9991594 0.0006102583 1.467094e-02 3.974952e-02 12 123313620 123313719 100 - 1.511 1.454 -0.199
ENSG00000139697 E020 44.3958488 0.0005816308 4.223552e-06 3.054926e-05 12 123315373 123315444 72 - 1.639 1.454 -0.636
ENSG00000139697 E021 56.6977394 0.0004443207 4.600067e-06 3.302645e-05 12 123315548 123315660 113 - 1.735 1.589 -0.499
ENSG00000139697 E022 65.7457600 0.0035660219 1.534979e-06 1.224255e-05 12 123317221 123317356 136 - 1.806 1.628 -0.603
ENSG00000139697 E023 64.1579709 0.0004171375 7.437820e-06 5.088191e-05 12 123319900 123320031 132 - 1.786 1.663 -0.416
ENSG00000139697 E024 63.6048882 0.0004211424 4.608805e-05 2.619556e-04 12 123320432 123320607 176 - 1.776 1.675 -0.344
ENSG00000139697 E025 54.9020075 0.0004242412 5.677067e-06 3.990292e-05 12 123320699 123320866 168 - 1.723 1.575 -0.503
ENSG00000139697 E026 59.1471558 0.0006651033 9.688063e-04 3.851864e-03 12 123321535 123321732 198 - 1.737 1.669 -0.229
ENSG00000139697 E027 41.3739516 0.0014271928 5.017854e-02 1.094778e-01 12 123323680 123323831 152 - 1.570 1.553 -0.057
ENSG00000139697 E028 38.2214611 0.0005902368 1.409788e-03 5.339405e-03 12 123325502 123325599 98 - 1.558 1.454 -0.357
ENSG00000139697 E029 52.0221476 0.0005953918 3.469823e-08 3.859938e-07 12 123326152 123326334 183 - 1.714 1.489 -0.766
ENSG00000139697 E030 41.5209248 0.0018769682 1.899808e-06 1.485464e-05 12 123327426 123327579 154 - 1.618 1.394 -0.769
ENSG00000139697 E031 39.0236202 0.0006099587 3.376727e-09 4.540499e-08 12 123327707 123327812 106 - 1.605 1.285 -1.104
ENSG00000139697 E032 41.8353199 0.0134297560 3.457305e-05 2.024405e-04 12 123327892 123328027 136 - 1.627 1.363 -0.907
ENSG00000139697 E033 41.5609227 0.0004975981 2.087855e-09 2.912221e-08 12 123328734 123328895 162 - 1.632 1.324 -1.060
ENSG00000139697 E034 34.9953060 0.0015054461 1.426822e-04 7.150982e-04 12 123330419 123330509 91 - 1.539 1.372 -0.575
ENSG00000139697 E035 40.5688868 0.0005463417 6.391639e-08 6.740575e-07 12 123331242 123331326 85 - 1.614 1.349 -0.913
ENSG00000139697 E036 25.7194207 0.0020073612 3.991622e-07 3.599414e-06 12 123331327 123331375 49 - 1.435 1.078 -1.258
ENSG00000139697 E037 36.5072839 0.0035851178 9.271002e-06 6.209792e-05 12 123334053 123334213 161 - 1.562 1.325 -0.816
ENSG00000139697 E038 27.8153217 0.0010263883 1.599209e-04 7.915077e-04 12 123336395 123336488 94 - 1.441 1.242 -0.693
ENSG00000139697 E039 15.1764198 0.0013406328 2.431795e-03 8.557721e-03 12 123336489 123336491 3 - 1.198 0.979 -0.793
ENSG00000139697 E040 32.4113704 0.0017218903 1.783366e-07 1.726208e-06 12 123340988 123341088 101 - 1.525 1.211 -1.093
ENSG00000139697 E041 57.2340307 0.0184653696 5.584239e-07 4.895725e-06 12 123345258 123345567 310 - 1.771 1.421 -1.196
ENSG00000139697 E042 6.1488597 0.0058352832 7.424341e-03 2.232180e-02 12 123345568 123345570 3 - 0.871 0.536 -1.400
ENSG00000139697 E043 13.7732321 0.0013003053 6.137609e-05 3.382649e-04 12 123348029 123348034 6 - 1.183 0.812 -1.379
ENSG00000139697 E044 24.6675139 0.0007758707 3.879578e-09 5.158077e-08 12 123348035 123348133 99 - 1.433 0.979 -1.613
ENSG00000139697 E045 26.2010831 0.0204539465 5.116919e-04 2.203498e-03 12 123350310 123350441 132 - 1.435 1.159 -0.968
ENSG00000139697 E046 0.8772652 0.0928177946 1.275624e-01 2.307532e-01 12 123357809 123357852 44 - 0.310 0.000 -10.964
ENSG00000139697 E047 0.0000000       12 123357853 123357917 65 -      
ENSG00000139697 E048 14.5371198 0.0156115867 2.726966e-02 6.653815e-02 12 123364701 123364763 63 - 1.173 1.007 -0.601
ENSG00000139697 E049 9.5255799 0.0168730203 2.216311e-01 3.523493e-01 12 123364764 123364847 84 - 0.986 0.920 -0.247
ENSG00000139697 E050 0.2214452 0.0421359862 1.731788e-01   12 123383627 123383718 92 - 0.000 0.207 11.730