ENSG00000139687

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267163 ENSG00000139687 HEK293_OSMI2_2hA HEK293_TMG_2hB RB1 protein_coding protein_coding 12.22313 5.372938 20.6287 0.5031225 0.6914739 1.938887 10.8002338 2.325537 19.84798059 0.3002995 0.60832558 3.087892 0.7417750 0.4483000 0.962400000 0.5141 9.562324e-11 5.037469e-11 FALSE TRUE
ENST00000531171 ENSG00000139687 HEK293_OSMI2_2hA HEK293_TMG_2hB RB1 protein_coding processed_transcript 12.22313 5.372938 20.6287 0.5031225 0.6914739 1.938887 0.9561022 2.581739 0.02529939 0.8073908 0.02529939 -6.198133 0.1960167 0.4602667 0.001166667 -0.4591 5.037469e-11 5.037469e-11   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139687 E001 0.8773789 0.3475904225 5.835137e-01 7.076188e-01 13 48303744 48303746 3 + 0.231 0.000 -10.735
ENSG00000139687 E002 0.8773789 0.3475904225 5.835137e-01 7.076188e-01 13 48303747 48303750 4 + 0.231 0.000 -10.652
ENSG00000139687 E003 3.9744409 0.0960008829 7.742351e-01 8.544495e-01 13 48303751 48303774 24 + 0.569 0.570 0.007
ENSG00000139687 E004 54.0633357 0.0018588333 9.481167e-04 3.781465e-03 13 48303775 48304049 275 + 1.598 1.460 -0.472
ENSG00000139687 E005 68.3617519 0.0009017900 1.456422e-04 7.284111e-04 13 48307280 48307406 127 + 1.697 1.557 -0.477
ENSG00000139687 E006 1.8736878 0.1262162408 3.435955e-02 8.044533e-02 13 48333017 48333216 200 + 0.232 0.747 2.697
ENSG00000139687 E007 72.6884909 0.0016772904 1.749894e-05 1.099616e-04 13 48342599 48342714 116 + 1.725 1.547 -0.607
ENSG00000139687 E008 76.9183084 0.0028526298 3.467646e-05 2.029537e-04 13 48345080 48345199 120 + 1.749 1.579 -0.576
ENSG00000139687 E009 62.9036950 0.0061956923 1.017765e-03 4.020110e-03 13 48347825 48347863 39 + 1.661 1.513 -0.505
ENSG00000139687 E010 63.1477414 0.0024672752 8.946961e-04 3.595314e-03 13 48348956 48349023 68 + 1.661 1.535 -0.428
ENSG00000139687 E011 87.0594187 0.0004086047 8.975483e-06 6.032706e-05 13 48360017 48360127 111 + 1.801 1.654 -0.498
ENSG00000139687 E012 0.1451727 0.0427500307 1.000000e+00   13 48360128 48360737 610 + 0.048 0.000 -8.073
ENSG00000139687 E013 84.4918361 0.0003210651 7.892198e-06 5.368015e-05 13 48362815 48362957 143 + 1.788 1.636 -0.517
ENSG00000139687 E014 39.7985130 0.0005325749 2.667011e-01 4.049379e-01 13 48364894 48364971 78 + 1.449 1.474 0.086
ENSG00000139687 E015 63.3884124 0.0004033148 2.011302e-03 7.261269e-03 13 48367494 48367603 110 + 1.659 1.568 -0.313
ENSG00000139687 E016 78.3694750 0.0003920276 2.929015e-04 1.350894e-03 13 48368527 48368604 78 + 1.750 1.645 -0.357
ENSG00000139687 E017 90.3755084 0.0003316335 2.254530e-05 1.381173e-04 13 48373405 48373492 88 + 1.814 1.687 -0.431
ENSG00000139687 E018 102.1325190 0.0007203803 4.165150e-04 1.837708e-03 13 48376918 48377034 117 + 1.860 1.787 -0.247
ENSG00000139687 E019 59.5368110 0.0004383027 4.907474e-02 1.075103e-01 13 48379594 48379650 57 + 1.624 1.608 -0.056
ENSG00000139687 E020 52.5106952 0.0004502804 3.384808e-01 4.823506e-01 13 48380053 48380084 32 + 1.560 1.608 0.162
ENSG00000139687 E021 70.8690970 0.0005537909 1.080433e-01 2.026370e-01 13 48380165 48380241 77 + 1.693 1.710 0.060
ENSG00000139687 E022 35.0674784 0.0011183753 3.604574e-02 8.367139e-02 13 48381247 48381249 3 + 1.409 1.336 -0.252
ENSG00000139687 E023 90.9169067 0.0023105352 3.489390e-02 8.144978e-02 13 48381250 48381443 194 + 1.802 1.794 -0.025
ENSG00000139687 E024 0.0000000       13 48444828 48445221 394 +      
ENSG00000139687 E025 74.8652793 0.0026798066 6.417673e-01 7.547295e-01 13 48452993 48453111 119 + 1.704 1.788 0.284
ENSG00000139687 E026 90.7204894 0.0020904601 1.100902e-01 2.056702e-01 13 48456204 48456349 146 + 1.796 1.819 0.077
ENSG00000139687 E027 106.4808789 0.0033769135 6.995943e-02 1.433070e-01 13 48459688 48459833 146 + 1.867 1.880 0.043
ENSG00000139687 E028 84.8316563 0.0011956481 1.138999e-01 2.112095e-01 13 48463731 48463835 105 + 1.769 1.793 0.084
ENSG00000139687 E029 80.8578161 0.0022704685 5.288555e-01 6.617269e-01 13 48464998 48465111 114 + 1.742 1.818 0.257
ENSG00000139687 E030 105.7923653 0.0002952865 3.257997e-01 4.692387e-01 13 48465205 48465368 164 + 1.842 1.999 0.531
ENSG00000139687 E031 48.5152918 0.0017786338 1.295758e-01 2.335589e-01 13 48473360 48473390 31 + 1.498 1.711 0.723
ENSG00000139687 E032 0.6234634 0.0190006029 7.122055e-03 2.154185e-02 13 48476400 48476446 47 + 0.048 0.567 4.514
ENSG00000139687 E033 1.3577460 0.0199424101 1.665870e-01 2.837567e-01 13 48476447 48476522 76 + 0.232 0.567 1.929
ENSG00000139687 E034 2.5797705 0.0059928349 1.227904e-01 2.239405e-01 13 48476523 48476700 178 + 0.383 0.740 1.667
ENSG00000139687 E035 124.2347214 0.0002673353 9.434497e-01 9.685312e-01 13 48476701 48476843 143 + 1.917 2.033 0.392
ENSG00000139687 E036 88.1673448 0.0003698192 7.399845e-01 8.295188e-01 13 48477355 48477404 50 + 1.769 1.899 0.438
ENSG00000139687 E037 0.1472490 0.0437357150 1.000000e+00   13 48479979 48479997 19 + 0.048 0.000 -8.073
ENSG00000139687 E038 573.0818250 0.0311103895 2.618757e-06 1.986767e-05 13 48479998 48481890 1893 + 2.505 2.939 1.444
ENSG00000139687 E039 0.0000000       13 48599302 48599436 135 +