ENSG00000139651

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000416904 ENSG00000139651 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF740 protein_coding protein_coding 26.99933 27.22188 22.87539 2.50638 0.6956343 -0.2508693 4.881603 4.4316580 4.719489 0.3573069 0.02687456 0.09058600 0.18275000 0.16356667 0.20666667 0.04310000 1.353719e-01 2.026024e-28 FALSE TRUE
ENST00000549739 ENSG00000139651 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF740 protein_coding retained_intron 26.99933 27.22188 22.87539 2.50638 0.6956343 -0.2508693 1.962555 0.5486038 1.241845 0.1813491 0.13754173 1.16415932 0.06947917 0.01973333 0.05463333 0.03490000 2.504963e-02 2.026024e-28 FALSE FALSE
ENST00000551514 ENSG00000139651 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF740 protein_coding processed_transcript 26.99933 27.22188 22.87539 2.50638 0.6956343 -0.2508693 3.893592 9.2826796 0.000000 1.8930916 0.00000000 -9.85995085 0.13260417 0.33816667 0.00000000 -0.33816667 2.026024e-28 2.026024e-28   FALSE
ENST00000552593 ENSG00000139651 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF740 protein_coding retained_intron 26.99933 27.22188 22.87539 2.50638 0.6956343 -0.2508693 5.112393 3.5126823 5.539678 0.1724749 0.68691029 0.65572978 0.19370833 0.13133333 0.24080000 0.10946667 1.051398e-02 2.026024e-28 FALSE FALSE
MSTRG.7349.4 ENSG00000139651 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF740 protein_coding   26.99933 27.22188 22.87539 2.50638 0.6956343 -0.2508693 7.696522 6.2644399 6.573163 1.1702305 0.69377130 0.06929419 0.28929583 0.22580000 0.28603333 0.06023333 4.871975e-01 2.026024e-28 TRUE TRUE
MSTRG.7349.6 ENSG00000139651 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF740 protein_coding   26.99933 27.22188 22.87539 2.50638 0.6956343 -0.2508693 3.031083 3.1548939 4.239182 0.9576886 0.33382206 0.42502783 0.11756667 0.12043333 0.18600000 0.06556667 5.039949e-01 2.026024e-28 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139651 E001 0.000000       12 53178891 53179062 172 +      
ENSG00000139651 E002 4.583882 0.0668816334 9.897919e-02 1.889187e-01 12 53179063 53180703 1641 + 0.858 0.628 -0.937
ENSG00000139651 E003 5.682491 0.0659612960 1.268924e-01 2.298198e-01 12 53180704 53180717 14 + 0.930 0.716 -0.836
ENSG00000139651 E004 6.671541 0.0903728375 1.800921e-01 3.012912e-01 12 53180718 53180721 4 + 0.977 0.791 -0.711
ENSG00000139651 E005 7.546740 0.1113763198 2.809501e-01 4.208087e-01 12 53180722 53180726 5 + 1.006 0.857 -0.560
ENSG00000139651 E006 11.672277 0.0814677134 1.028781e-01 1.948663e-01 12 53180727 53180738 12 + 1.204 0.992 -0.769
ENSG00000139651 E007 39.452749 0.0278877308 5.434182e-03 1.710996e-02 12 53180739 53180795 57 + 1.710 1.492 -0.743
ENSG00000139651 E008 56.874140 0.0233568157 3.461566e-02 8.093032e-02 12 53180796 53180837 42 + 1.826 1.695 -0.444
ENSG00000139651 E009 92.907300 0.0048484070 1.649604e-03 6.119777e-03 12 53181677 53181733 57 + 2.020 1.924 -0.321
ENSG00000139651 E010 77.494950 0.0016196565 3.660676e-04 1.642946e-03 12 53181734 53181754 21 + 1.942 1.849 -0.313
ENSG00000139651 E011 150.071524 0.0039838040 1.274527e-04 6.475938e-04 12 53181755 53181858 104 + 2.228 2.130 -0.330
ENSG00000139651 E012 181.545331 0.0004403214 1.888934e-09 2.657850e-08 12 53181859 53181992 134 + 2.312 2.212 -0.334
ENSG00000139651 E013 35.476614 0.0107080981 1.130061e-01 2.099280e-01 12 53181993 53182190 198 + 1.594 1.528 -0.226
ENSG00000139651 E014 155.407353 0.0004450407 8.011166e-04 3.263712e-03 12 53184891 53185040 150 + 2.216 2.182 -0.111
ENSG00000139651 E015 1.251168 0.0267415100 8.229638e-01 8.884002e-01 12 53185385 53185386 2 + 0.363 0.360 -0.020
ENSG00000139651 E016 129.438749 0.0012845597 2.243523e-01 3.556309e-01 12 53185387 53185476 90 + 2.107 2.129 0.072
ENSG00000139651 E017 140.796216 0.0002607349 9.050320e-03 2.640337e-02 12 53185954 53186077 124 + 2.162 2.149 -0.044
ENSG00000139651 E018 161.931348 0.0002530279 1.850907e-04 8.995609e-04 12 53186391 53186509 119 + 2.234 2.195 -0.133
ENSG00000139651 E019 9.766967 0.0293394810 3.532304e-02 8.227148e-02 12 53186510 53186794 285 + 1.139 0.937 -0.739
ENSG00000139651 E020 163.203117 0.0003891195 2.237815e-06 1.722383e-05 12 53187501 53187606 106 + 2.253 2.184 -0.232
ENSG00000139651 E021 181.796904 0.0002055616 2.926821e-03 1.004925e-02 12 53187607 53187763 157 + 2.270 2.256 -0.046
ENSG00000139651 E022 571.986159 0.0001327462 4.446753e-02 9.923387e-02 12 53187764 53188536 773 + 2.740 2.775 0.117
ENSG00000139651 E023 215.116140 0.0001764337 1.223875e-01 2.233564e-01 12 53188537 53188664 128 + 2.322 2.349 0.091
ENSG00000139651 E024 1354.025411 0.0037959949 2.037832e-15 7.388730e-14 12 53188665 53190988 2324 + 2.987 3.221 0.778
ENSG00000139651 E025 4.247553 0.5196355507 8.016974e-01 8.736370e-01 12 53190989 53191936 948 + 0.751 0.677 -0.303
ENSG00000139651 E026 14.476749 0.0926106628 1.629748e-01 2.790184e-01 12 53191937 53194262 2326 + 1.009 1.286 0.993
ENSG00000139651 E027 5.771846 0.0633638216 1.165608e-01 2.150427e-01 12 53194263 53195142 880 + 0.632 0.942 1.239