ENSG00000139645

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267116 ENSG00000139645 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD52 protein_coding protein_coding 30.29565 39.28885 24.59809 3.35305 0.8816168 -0.675354 23.907266 27.701857 20.898985 1.907886 0.4644403 -0.4063803 0.7988333 0.7082 0.8506333 0.1424333 3.819154e-03 4.977689e-06 FALSE TRUE
MSTRG.7458.7 ENSG00000139645 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD52 protein_coding   30.29565 39.28885 24.59809 3.35305 0.8816168 -0.675354 4.168274 9.656302 1.731669 2.208549 0.1550244 -2.4724933 0.1213667 0.2410 0.0708000 -0.1702000 9.590106e-05 4.977689e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139645 E001 0.2934659 0.0309836113 7.550937e-01   12 56229854 56229878 25 -      
ENSG00000139645 E002 0.2214452 0.0382796162 7.141250e-01   12 56237172 56237223 52 -      
ENSG00000139645 E003 19.8606321 0.0141162440 6.809299e-09 8.661215e-08 12 56237807 56237835 29 -      
ENSG00000139645 E004 77.9328214 0.0230473387 6.791504e-10 1.039617e-08 12 56237836 56237891 56 -      
ENSG00000139645 E005 159.2457706 0.0281348261 5.157548e-11 9.561424e-10 12 56237892 56237968 77 -      
ENSG00000139645 E006 5502.3016546 0.0119544007 3.103902e-11 5.963137e-10 12 56237969 56243237 5269 -      
ENSG00000139645 E007 206.7066536 0.0021032054 5.848348e-02 1.240347e-01 12 56243238 56243392 155 -      
ENSG00000139645 E008 179.5321383 0.0006075700 5.495519e-02 1.179153e-01 12 56243785 56243876 92 -      
ENSG00000139645 E009 169.7814147 0.0002277262 1.553101e-04 7.707006e-04 12 56244051 56244133 83 -      
ENSG00000139645 E010 189.4197865 0.0002054489 1.391867e-05 8.945149e-05 12 56244353 56244435 83 -      
ENSG00000139645 E011 244.6119383 0.0023597926 4.198745e-06 3.038464e-05 12 56244652 56244797 146 -      
ENSG00000139645 E012 195.9238711 0.0055739261 2.333059e-04 1.105392e-03 12 56244906 56244989 84 -      
ENSG00000139645 E013 179.4578398 0.0085283238 1.170407e-04 6.002275e-04 12 56245103 56245190 88 -      
ENSG00000139645 E014 242.7699811 0.0107835728 1.608041e-03 5.987276e-03 12 56245377 56245596 220 -      
ENSG00000139645 E015 173.6373907 0.0077332159 1.508506e-03 5.663757e-03 12 56247493 56247610 118 -      
ENSG00000139645 E016 165.9865498 0.0033201484 3.456231e-06 2.553417e-05 12 56247687 56247774 88 -      
ENSG00000139645 E017 221.8388444 0.0024731787 2.284905e-08 2.634943e-07 12 56248023 56248224 202 -      
ENSG00000139645 E018 147.7985654 0.0092975888 2.702039e-04 1.258527e-03 12 56248495 56248566 72 -      
ENSG00000139645 E019 168.1469395 0.0095561404 3.961419e-04 1.759622e-03 12 56248759 56248870 112 -      
ENSG00000139645 E020 170.5104570 0.0054445478 5.077124e-05 2.856685e-04 12 56252015 56252095 81 -      
ENSG00000139645 E021 130.2479127 0.0066862788 7.565226e-04 3.102789e-03 12 56252175 56252228 54 -      
ENSG00000139645 E022 137.9962192 0.0081477948 4.469257e-05 2.548037e-04 12 56252229 56252315 87 -      
ENSG00000139645 E023 144.4107269 0.0118161536 8.935503e-05 4.719539e-04 12 56252502 56252570 69 -      
ENSG00000139645 E024 175.5933475 0.0027487883 4.956108e-13 1.277094e-11 12 56252780 56252897 118 -      
ENSG00000139645 E025 145.3604919 0.0094480923 7.847851e-05 4.208066e-04 12 56253004 56253086 83 -      
ENSG00000139645 E026 176.9282326 0.0159271412 6.258087e-04 2.627706e-03 12 56253288 56253402 115 -      
ENSG00000139645 E027 159.2362452 0.0165518770 9.409619e-04 3.757402e-03 12 56253722 56253800 79 -      
ENSG00000139645 E028 110.6059775 0.0118242471 4.317669e-05 2.470162e-04 12 56254067 56254086 20 -      
ENSG00000139645 E029 191.2928275 0.0089380686 3.481049e-08 3.870381e-07 12 56254087 56254229 143 -      
ENSG00000139645 E030 121.1155571 0.0079613063 8.686119e-08 8.923373e-07 12 56254230 56254279 50 -      
ENSG00000139645 E031 156.8172031 0.0045664053 1.788505e-09 2.528937e-08 12 56254578 56254720 143 -      
ENSG00000139645 E032 109.8814770 0.0025824647 7.100758e-16 2.735850e-14 12 56254865 56254952 88 -      
ENSG00000139645 E033 2.8346269 0.0054670400 2.179415e-02 5.524636e-02 12 56254953 56255084 132 -      
ENSG00000139645 E034 2.3563481 0.0064721509 3.616463e-02 8.390522e-02 12 56255194 56255322 129 -      
ENSG00000139645 E035 2.1746423 0.0071418215 1.138333e-01 2.111086e-01 12 56255323 56255539 217 -      
ENSG00000139645 E036 3.4740721 0.0050508916 1.343170e-02 3.691992e-02 12 56255540 56255783 244 -      
ENSG00000139645 E037 144.2865513 0.0002550836 3.400655e-32 6.648543e-30 12 56255784 56255984 201 -      
ENSG00000139645 E038 10.0320445 0.0262407127 6.595177e-05 3.605773e-04 12 56255985 56257014 1030 -      
ENSG00000139645 E039 105.2241090 0.0045937677 4.991795e-14 1.482026e-12 12 56257015 56257085 71 -      
ENSG00000139645 E040 3.3580602 0.0045420644 3.739189e-04 1.673308e-03 12 56257086 56257282 197 -      
ENSG00000139645 E041 103.1909373 0.0004340751 4.734070e-17 2.116223e-15 12 56257283 56257361 79 -      
ENSG00000139645 E042 4.4413816 0.0083124917 1.206552e-04 6.170101e-04 12 56257362 56257518 157 -      
ENSG00000139645 E043 6.3379972 0.0271044878 4.887390e-03 1.561675e-02 12 56257519 56257827 309 -      
ENSG00000139645 E044 78.5319568 0.0006879164 1.543773e-18 8.301537e-17 12 56257828 56257911 84 -      
ENSG00000139645 E045 64.2527125 0.0042454708 8.359090e-11 1.494813e-09 12 56258243 56258419 177 -