ENSG00000139644

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267115 ENSG00000139644 HEK293_OSMI2_2hA HEK293_TMG_2hB TMBIM6 protein_coding protein_coding 307.2265 278.6134 318.7708 20.58203 2.453264 0.1942483 199.91165 242.62599 180.56001 17.28233 2.792618 -0.4262352 0.6668625 0.8736333 0.5664333 -0.3072000 1.698403e-02 1.759441e-75 FALSE TRUE
ENST00000547798 ENSG00000139644 HEK293_OSMI2_2hA HEK293_TMG_2hB TMBIM6 protein_coding protein_coding 307.2265 278.6134 318.7708 20.58203 2.453264 0.1942483 68.35965 26.54146 73.38303 15.05046 6.835997 1.4668518 0.2150000 0.0927000 0.2300333 0.1373333 6.645664e-01 1.759441e-75 FALSE TRUE
MSTRG.7266.16 ENSG00000139644 HEK293_OSMI2_2hA HEK293_TMG_2hB TMBIM6 protein_coding   307.2265 278.6134 318.7708 20.58203 2.453264 0.1942483 28.26051 0.00000 50.47376 0.00000 4.494212 12.3016035 0.0837125 0.0000000 0.1585000 0.1585000 1.759441e-75 1.759441e-75 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139644 E001 0.000000e+00       12 49707725 49707732 8 +      
ENSG00000139644 E002 0.000000e+00       12 49707733 49707839 107 +      
ENSG00000139644 E003 0.000000e+00       12 49715381 49715543 163 +      
ENSG00000139644 E004 0.000000e+00       12 49715544 49715777 234 +      
ENSG00000139644 E005 0.000000e+00       12 49738993 49739082 90 +      
ENSG00000139644 E006 0.000000e+00       12 49741202 49741329 128 +      
ENSG00000139644 E007 3.854986e+00 0.0145335904 1.766795e-01 2.969297e-01 12 49741544 49741546 3 + 0.779 0.586 -0.815
ENSG00000139644 E008 6.310904e+00 0.0026370204 5.225070e-03 1.654339e-02 12 49741547 49741548 2 + 1.016 0.681 -1.303
ENSG00000139644 E009 1.117273e+01 0.0015473855 7.542412e-02 1.521987e-01 12 49741549 49741556 8 + 1.168 1.008 -0.581
ENSG00000139644 E010 7.260866e+01 0.0003551394 9.585307e-28 1.327418e-25 12 49741557 49741567 11 + 2.061 1.605 -1.540
ENSG00000139644 E011 1.233839e+02 0.0002371836 1.817217e-22 1.527357e-20 12 49741568 49741570 3 + 2.237 1.935 -1.013
ENSG00000139644 E012 1.825079e+02 0.0001967069 6.581298e-17 2.896857e-15 12 49741571 49741573 3 + 2.368 2.159 -0.697
ENSG00000139644 E013 7.683633e+02 0.0023565744 1.886535e-01 3.120401e-01 12 49741574 49741607 34 + 2.899 2.871 -0.093
ENSG00000139644 E014 7.695254e+02 0.0024396334 2.246169e-01 3.559758e-01 12 49741608 49741611 4 + 2.899 2.873 -0.086
ENSG00000139644 E015 4.443253e+00 0.0445694285 4.238172e-01 5.668499e-01 12 49741612 49741768 157 + 0.803 0.702 -0.408
ENSG00000139644 E016 4.439371e-01 0.0215514502 7.279235e-02 1.479931e-01 12 49741809 49741821 13 + 0.302 0.000 -17.786
ENSG00000139644 E017 1.016141e+01 0.0025570902 9.617036e-01 9.798585e-01 12 49741822 49741951 130 + 1.030 1.047 0.062
ENSG00000139644 E018 1.047704e+01 0.0016189712 9.175214e-01 9.518842e-01 12 49741952 49741956 5 + 1.056 1.058 0.009
ENSG00000139644 E019 4.313805e+01 0.0005077117 2.103343e-01 3.389520e-01 12 49741957 49742115 159 + 1.674 1.621 -0.179
ENSG00000139644 E020 6.953919e+00 0.0042080422 1.074376e-01 2.017658e-01 12 49742116 49742280 165 + 0.987 0.805 -0.693
ENSG00000139644 E021 1.355655e+00 0.0415985310 9.248112e-01 9.566547e-01 12 49742281 49742437 157 + 0.369 0.356 -0.074
ENSG00000139644 E022 3.319346e+00 0.0046370288 8.468661e-01 9.048398e-01 12 49742438 49742607 170 + 0.638 0.620 -0.080
ENSG00000139644 E023 6.070705e+00 0.0028658596 2.186474e-01 3.487970e-01 12 49743417 49743565 149 + 0.922 0.783 -0.541
ENSG00000139644 E024 2.586125e+00 0.0071113390 3.648318e-01 5.091664e-01 12 49744413 49744542 130 + 0.638 0.507 -0.598
ENSG00000139644 E025 1.619876e+00 0.0085032723 8.894481e-01 9.333271e-01 12 49749618 49749734 117 + 0.427 0.412 -0.081
ENSG00000139644 E026 1.169708e+00 0.3044663975 3.653227e-02 8.459242e-02 12 49749735 49749856 122 + 0.000 0.473 18.402
ENSG00000139644 E027 1.281459e+00 0.0126987236 4.126812e-01 5.562401e-01 12 49750620 49750705 86 + 0.427 0.290 -0.817
ENSG00000139644 E028 4.059895e+00 0.0044077256 7.125662e-01 8.092556e-01 12 49752456 49752463 8 + 0.670 0.735 0.266
ENSG00000139644 E029 8.253476e+02 0.0023735509 6.182933e-01 7.359870e-01 12 49752464 49752465 2 + 2.918 2.912 -0.019
ENSG00000139644 E030 1.244539e+03 0.0028183794 9.349808e-01 9.630728e-01 12 49752466 49752549 84 + 3.090 3.095 0.015
ENSG00000139644 E031 1.726453e+00 0.0095184413 2.990852e-01 4.405692e-01 12 49752964 49752972 9 + 0.524 0.355 -0.888
ENSG00000139644 E032 1.500789e+03 0.0017118906 1.339484e-01 2.396371e-01 12 49752973 49753037 65 + 3.188 3.162 -0.086
ENSG00000139644 E033 1.341784e+03 0.0013397591 1.316941e-01 2.364950e-01 12 49753038 49753081 44 + 3.138 3.116 -0.075
ENSG00000139644 E034 2.385917e+03 0.0010112519 1.246301e-01 2.266020e-01 12 49755635 49755755 121 + 3.385 3.368 -0.058
ENSG00000139644 E035 3.790060e+00 0.0041701552 9.671950e-02 1.854600e-01 12 49755756 49755756 1 + 0.524 0.782 1.111
ENSG00000139644 E036 5.725755e+00 0.0029454423 7.869517e-01 8.635800e-01 12 49758207 49758226 20 + 0.847 0.825 -0.082
ENSG00000139644 E037 1.795395e+03 0.0004057180 1.751301e-01 2.948488e-01 12 49758227 49758275 49 + 3.257 3.251 -0.019
ENSG00000139644 E038 1.177365e+01 0.0201333347 8.090282e-01 8.786941e-01 12 49758352 49758382 31 + 1.116 1.101 -0.053
ENSG00000139644 E039 2.505564e+03 0.0006794296 1.873029e-01 3.103455e-01 12 49758383 49758480 98 + 3.402 3.394 -0.028
ENSG00000139644 E040 1.159106e+01 0.0620164058 3.903321e-01 5.343125e-01 12 49758481 49758682 202 + 1.170 1.040 -0.468
ENSG00000139644 E041 2.247298e+03 0.0012976204 3.125414e-01 4.550732e-01 12 49758683 49758762 80 + 3.355 3.346 -0.029
ENSG00000139644 E042 1.157195e+01 0.0021781519 3.371604e-04 1.529038e-03 12 49758804 49759135 332 + 1.257 0.918 -1.230
ENSG00000139644 E043 9.378538e+00 0.0019938364 1.734275e-01 2.926481e-01 12 49759136 49759220 85 + 1.081 0.950 -0.481
ENSG00000139644 E044 2.554485e+03 0.0002894605 1.287690e-01 2.324453e-01 12 49759221 49759321 101 + 3.391 3.418 0.090
ENSG00000139644 E045 2.405258e+03 0.0001143676 5.223403e-02 1.131324e-01 12 49761704 49761779 76 + 3.383 3.379 -0.013
ENSG00000139644 E046 1.154150e+01 0.0015078369 5.994431e-02 1.265125e-01 12 49761780 49762137 358 + 1.178 1.008 -0.615
ENSG00000139644 E047 1.433594e+04 0.0013836935 2.732575e-01 4.122613e-01 12 49762873 49764502 1630 + 4.156 4.151 -0.017
ENSG00000139644 E048 2.710520e+03 0.0045130111 5.444225e-10 8.479751e-09 12 49764503 49764827 325 + 3.299 3.511 0.703
ENSG00000139644 E049 3.031437e+02 0.0002084943 2.480053e-96 6.809254e-93 12 49764828 49764934 107 + 2.135 2.642 1.690