ENSG00000139624

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317551 ENSG00000139624 HEK293_OSMI2_2hA HEK293_TMG_2hB CERS5 protein_coding protein_coding 41.07882 51.76254 34.70276 4.015022 2.787838 -0.576721 5.543066 7.028361 5.281085 0.9580315 1.037358 -0.4116760 0.1391458 0.1367333 0.1583667 0.02163333 0.920425445 0.002424707 FALSE TRUE
ENST00000550919 ENSG00000139624 HEK293_OSMI2_2hA HEK293_TMG_2hB CERS5 protein_coding protein_coding 41.07882 51.76254 34.70276 4.015022 2.787838 -0.576721 13.998058 22.491603 9.039935 2.5518059 1.476624 -1.3140485 0.3306125 0.4334667 0.2574000 -0.17606667 0.002424707 0.002424707   FALSE
MSTRG.7273.10 ENSG00000139624 HEK293_OSMI2_2hA HEK293_TMG_2hB CERS5 protein_coding   41.07882 51.76254 34.70276 4.015022 2.787838 -0.576721 15.755090 17.678639 13.781263 1.4460469 1.278460 -0.3590685 0.3875083 0.3418333 0.3965000 0.05466667 0.182510635 0.002424707 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139624 E001 0.0000000       12 50129289 50129305 17 -      
ENSG00000139624 E002 2.7258841 0.0139676980 4.984212e-01 6.348780e-01 12 50129306 50129791 486 - 0.629 0.524 -0.473
ENSG00000139624 E003 1.7432783 0.0297787319 1.145669e-01 2.122074e-01 12 50129792 50129797 6 - 0.585 0.310 -1.451
ENSG00000139624 E004 2.2184486 0.0067827583 1.702382e-01 2.884843e-01 12 50129798 50129798 1 - 0.629 0.409 -1.057
ENSG00000139624 E005 40.9259483 0.0006539681 3.561465e-04 1.603929e-03 12 50129799 50129857 59 - 1.457 1.675 0.746
ENSG00000139624 E006 541.3977394 0.0032128585 4.068344e-06 2.953236e-05 12 50129858 50130323 466 - 2.621 2.758 0.455
ENSG00000139624 E007 227.0831542 0.0002384846 1.411247e-02 3.848267e-02 12 50130324 50130412 89 - 2.296 2.362 0.222
ENSG00000139624 E008 452.3493127 0.0003695204 4.288955e-02 9.633862e-02 12 50130413 50130694 282 - 2.611 2.654 0.141
ENSG00000139624 E009 3.6107516 0.0044911126 1.165604e-02 3.271507e-02 12 50132962 50133064 103 - 0.851 0.489 -1.548
ENSG00000139624 E010 1.9197859 0.0075600697 5.441461e-02 1.169780e-01 12 50133065 50133078 14 - 0.629 0.310 -1.641
ENSG00000139624 E011 3.8416350 0.0041325733 6.578713e-03 2.013144e-02 12 50133079 50133249 171 - 0.875 0.489 -1.641
ENSG00000139624 E012 7.3865197 0.0022747529 4.501985e-03 1.454819e-02 12 50133250 50133784 535 - 1.093 0.774 -1.202
ENSG00000139624 E013 17.5152059 0.0010587843 8.372253e-01 8.982307e-01 12 50133785 50134068 284 - 1.237 1.260 0.081
ENSG00000139624 E014 8.9705999 0.0136438928 7.008866e-01 8.002511e-01 12 50134400 50134545 146 - 1.015 0.979 -0.132
ENSG00000139624 E015 191.5486850 0.0002362134 6.029005e-01 7.237854e-01 12 50134546 50134572 27 - 2.256 2.276 0.066
ENSG00000139624 E016 211.6602225 0.0002241240 5.920312e-01 7.146676e-01 12 50134573 50134619 47 - 2.316 2.309 -0.025
ENSG00000139624 E017 262.9702938 0.0008798968 8.584812e-01 9.126895e-01 12 50134620 50134702 83 - 2.405 2.406 0.004
ENSG00000139624 E018 1.2772176 0.2938838603 9.068010e-01 9.448135e-01 12 50134703 50134828 126 - 0.345 0.358 0.078
ENSG00000139624 E019 0.0000000       12 50135406 50135432 27 -      
ENSG00000139624 E020 0.0000000       12 50135433 50135439 7 -      
ENSG00000139624 E021 0.1515154 0.0430773070 3.200014e-01   12 50135440 50135518 79 - 0.148 0.000 -12.089
ENSG00000139624 E022 0.1515154 0.0430773070 3.200014e-01   12 50135519 50135616 98 - 0.148 0.000 -12.089
ENSG00000139624 E023 0.0000000       12 50135617 50135652 36 -      
ENSG00000139624 E024 0.1472490 0.0437458722 3.198485e-01   12 50135653 50135731 79 - 0.148 0.000 -12.080
ENSG00000139624 E025 275.2890711 0.0003298986 5.095122e-01 6.448364e-01 12 50135732 50135838 107 - 2.412 2.433 0.070
ENSG00000139624 E026 142.2955814 0.0005894131 1.834688e-01 3.055541e-01 12 50135941 50135957 17 - 2.109 2.158 0.164
ENSG00000139624 E027 245.0399327 0.0001933913 9.865259e-01 9.956390e-01 12 50135958 50136069 112 - 2.371 2.378 0.022
ENSG00000139624 E028 185.7203354 0.0023161742 2.528528e-01 3.892874e-01 12 50137728 50137820 93 - 2.276 2.239 -0.123
ENSG00000139624 E029 145.1102815 0.0017484456 2.236038e-01 3.547027e-01 12 50138567 50138617 51 - 2.171 2.130 -0.134
ENSG00000139624 E030 106.2897291 0.0003299981 6.202502e-01 7.374916e-01 12 50142053 50142079 27 - 2.020 2.008 -0.040
ENSG00000139624 E031 98.9523843 0.0039196408 6.165899e-01 7.346194e-01 12 50142080 50142110 31 - 1.994 1.973 -0.071
ENSG00000139624 E032 1.1113933 0.1888194342 8.033322e-01 8.747894e-01 12 50143072 50143073 2 - 0.259 0.316 0.393
ENSG00000139624 E033 84.4933101 0.0078646693 4.956281e-01 6.324037e-01 12 50143074 50143079 6 - 1.936 1.896 -0.134
ENSG00000139624 E034 113.4429656 0.0021476356 5.099067e-02 1.109315e-01 12 50143080 50143137 58 - 2.085 2.010 -0.252
ENSG00000139624 E035 74.2224557 0.0028335766 9.008462e-03 2.630029e-02 12 50143138 50143164 27 - 1.932 1.811 -0.407
ENSG00000139624 E036 84.2291780 0.0020045598 1.726963e-02 4.554437e-02 12 50143165 50143204 40 - 1.973 1.873 -0.337
ENSG00000139624 E037 1.1821808 0.4236981722 8.965312e-01 9.378578e-01 12 50143205 50143951 747 - 0.258 0.388 0.832
ENSG00000139624 E038 99.3286543 0.0042078158 9.770679e-04 3.881452e-03 12 50143952 50144018 67 - 2.074 1.921 -0.512
ENSG00000139624 E039 107.7627256 0.0070172458 3.386219e-02 7.948125e-02 12 50144019 50144057 39 - 2.084 1.972 -0.375
ENSG00000139624 E040 0.3030308 0.3713923436 1.778745e-01   12 50144058 50144202 145 - 0.259 0.000 -12.151
ENSG00000139624 E041 1.6690821 0.1268473825 6.371738e-02 1.328886e-01 12 50144203 50144348 146 - 0.629 0.249 -2.076
ENSG00000139624 E042 0.5943067 0.0223018008 1.465470e-01 2.569923e-01 12 50144349 50144364 16 - 0.346 0.100 -2.228
ENSG00000139624 E043 2.4816237 0.0396359427 3.796404e-01 5.238978e-01 12 50144365 50144768 404 - 0.629 0.486 -0.656
ENSG00000139624 E044 11.0996053 0.0022933708 5.028923e-03 1.601093e-02 12 50144769 50144969 201 - 1.227 0.958 -0.974
ENSG00000139624 E045 0.1482932 0.0410787106 7.225154e-01   12 50144970 50145061 92 - 0.000 0.100 10.505
ENSG00000139624 E046 0.5932745 0.0235055997 6.471251e-01 7.588682e-01 12 50147326 50147403 78 - 0.258 0.182 -0.645
ENSG00000139624 E047 0.9630009 0.0707086458 2.015969e-01 3.281685e-01 12 50148472 50148588 117 - 0.419 0.182 -1.640
ENSG00000139624 E048 0.0000000       12 50153829 50153951 123 -      
ENSG00000139624 E049 0.8104664 0.0153826034 9.531716e-01 9.747087e-01 12 50154228 50154320 93 - 0.258 0.251 -0.057
ENSG00000139624 E050 0.5451131 0.6471250728 4.234062e-01 5.664603e-01 12 50157506 50157551 46 - 0.000 0.253 11.069
ENSG00000139624 E051 1.2876999 0.0104446030 9.464703e-01 9.703942e-01 12 50165822 50165935 114 - 0.346 0.362 0.095
ENSG00000139624 E052 0.6224193 0.0172671820 6.500065e-01 7.611117e-01 12 50165936 50165943 8 - 0.258 0.182 -0.642
ENSG00000139624 E053 1.8036577 0.0163029261 1.785334e-01 2.993125e-01 12 50165944 50166316 373 - 0.585 0.361 -1.131
ENSG00000139624 E054 156.4752531 0.0050618585 5.671135e-03 1.774280e-02 12 50167101 50167533 433 - 2.251 2.129 -0.406