ENSG00000139546

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000266987 ENSG00000139546 HEK293_OSMI2_2hA HEK293_TMG_2hB TARBP2 protein_coding protein_coding 87.64589 152.7185 54.73544 4.256188 1.285616 -1.480159 43.249307 82.276542 21.508721 4.4029852 0.5914530 -1.9350642 0.46441250 0.53816667 0.39373333 -0.14443333 8.718900e-04 1.344799e-27 FALSE TRUE
ENST00000546763 ENSG00000139546 HEK293_OSMI2_2hA HEK293_TMG_2hB TARBP2 protein_coding retained_intron 87.64589 152.7185 54.73544 4.256188 1.285616 -1.480159 3.681073 3.472697 2.602044 0.3757907 0.4663253 -0.4150257 0.05099167 0.02263333 0.04753333 0.02490000 2.609600e-02 1.344799e-27   FALSE
ENST00000552650 ENSG00000139546 HEK293_OSMI2_2hA HEK293_TMG_2hB TARBP2 protein_coding retained_intron 87.64589 152.7185 54.73544 4.256188 1.285616 -1.480159 3.893720 2.507205 4.190022 0.4631426 0.4044265 0.7385743 0.05565833 0.01626667 0.07636667 0.06010000 2.205111e-10 1.344799e-27 FALSE FALSE
MSTRG.7368.41 ENSG00000139546 HEK293_OSMI2_2hA HEK293_TMG_2hB TARBP2 protein_coding   87.64589 152.7185 54.73544 4.256188 1.285616 -1.480159 4.927742 10.911231 1.789540 2.5402388 0.8963894 -2.6014354 0.05338333 0.07120000 0.03326667 -0.03793333 6.653961e-01 1.344799e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139546 E001 0.0000000       12 53499708 53499714 7 +      
ENSG00000139546 E002 0.0000000       12 53499715 53499810 96 +      
ENSG00000139546 E003 0.0000000       12 53499811 53499931 121 +      
ENSG00000139546 E004 0.1817044 0.0404452204 1.000000e+00   12 53499932 53499962 31 + 0.000 0.071 9.481
ENSG00000139546 E005 0.3299976 0.0274424043 8.681201e-01   12 53499963 53500000 38 + 0.000 0.131 12.537
ENSG00000139546 E006 0.1482932 0.0416504127 1.000000e+00   12 53500001 53500013 13 + 0.000 0.070 11.372
ENSG00000139546 E007 0.1482932 0.0416504127 1.000000e+00   12 53500014 53500037 24 + 0.000 0.070 11.372
ENSG00000139546 E008 0.1482932 0.0416504127 1.000000e+00   12 53500038 53500093 56 + 0.000 0.070 11.372
ENSG00000139546 E009 0.3299976 0.0274424043 8.681201e-01   12 53500094 53500128 35 + 0.000 0.131 12.537
ENSG00000139546 E010 0.0000000       12 53500129 53500150 22 +      
ENSG00000139546 E011 0.1472490 0.0428731686 1.301870e-01   12 53500151 53500161 11 + 0.204 0.000 -14.199
ENSG00000139546 E012 0.1472490 0.0428731686 1.301870e-01   12 53500162 53500172 11 + 0.204 0.000 -14.199
ENSG00000139546 E013 0.1472490 0.0428731686 1.301870e-01   12 53500173 53500214 42 + 0.204 0.000 -14.199
ENSG00000139546 E014 6.4193345 0.0026212514 7.728620e-03 2.309735e-02 12 53500215 53500920 706 + 1.025 0.689 -1.305
ENSG00000139546 E015 9.6431117 0.0017975102 2.010011e-01 3.274237e-01 12 53500921 53500952 32 + 1.049 0.906 -0.531
ENSG00000139546 E016 15.4724932 0.0011356949 1.953176e-02 5.048136e-02 12 53500953 53501001 49 + 1.279 1.064 -0.765
ENSG00000139546 E017 22.3941699 0.0466721241 4.861146e-01 6.239360e-01 12 53501002 53501273 272 + 1.330 1.252 -0.272
ENSG00000139546 E018 11.3819392 0.0182639997 8.911838e-01 9.344985e-01 12 53501274 53501282 9 + 0.973 0.996 0.087
ENSG00000139546 E019 41.1876506 0.0380255125 2.688017e-01 4.072754e-01 12 53501283 53501295 13 + 1.620 1.496 -0.422
ENSG00000139546 E020 55.2690371 0.0228380633 7.126610e-02 1.454285e-01 12 53501296 53501301 6 + 1.767 1.612 -0.526
ENSG00000139546 E021 66.0362834 0.0180560011 1.188044e-01 2.182405e-01 12 53501302 53501304 3 + 1.814 1.697 -0.394
ENSG00000139546 E022 66.0665741 0.0199169827 1.167594e-01 2.153367e-01 12 53501305 53501305 1 + 1.817 1.696 -0.410
ENSG00000139546 E023 180.7974784 0.0042331581 3.660218e-02 8.471702e-02 12 53501306 53501331 26 + 2.218 2.138 -0.269
ENSG00000139546 E024 205.0376331 0.0039190629 6.350254e-02 1.325310e-01 12 53501332 53501349 18 + 2.262 2.196 -0.221
ENSG00000139546 E025 261.4945800 0.0032018055 1.112581e-01 2.073986e-01 12 53501350 53501365 16 + 2.353 2.305 -0.160
ENSG00000139546 E026 478.8760268 0.0006833841 7.144564e-01 8.106587e-01 12 53501366 53501461 96 + 2.576 2.577 0.003
ENSG00000139546 E027 4.4160067 0.0041784423 5.213613e-05 2.924362e-04 12 53501462 53501590 129 + 1.025 0.469 -2.305
ENSG00000139546 E028 9.6475514 0.0018027726 4.067200e-01 5.503446e-01 12 53501591 53501596 6 + 1.000 0.907 -0.349
ENSG00000139546 E029 10.4914290 0.0017120332 2.933089e-01 4.343421e-01 12 53501597 53501598 2 + 1.049 0.934 -0.425
ENSG00000139546 E030 10.6794630 0.0016315476 3.275927e-01 4.710512e-01 12 53501599 53501603 5 + 1.049 0.943 -0.392
ENSG00000139546 E031 13.1851193 0.0019806741 1.739702e-01 2.933419e-01 12 53501604 53501604 1 + 1.152 1.016 -0.495
ENSG00000139546 E032 23.2102968 0.0157641129 8.009027e-01 8.731074e-01 12 53501605 53501618 14 + 1.292 1.277 -0.055
ENSG00000139546 E033 80.5946120 0.0087594661 5.926244e-01 7.151424e-01 12 53501619 53501708 90 + 1.830 1.804 -0.087
ENSG00000139546 E034 304.1674981 0.0001721197 3.160146e-01 4.587799e-01 12 53502015 53502019 5 + 2.353 2.386 0.111
ENSG00000139546 E035 416.4159169 0.0001835607 3.219712e-01 4.652420e-01 12 53502020 53502050 31 + 2.527 2.513 -0.045
ENSG00000139546 E036 337.8369214 0.0001723471 1.521526e-01 2.646109e-01 12 53502051 53502059 9 + 2.446 2.420 -0.087
ENSG00000139546 E037 691.8167265 0.0006232338 7.530137e-01 8.390850e-01 12 53502060 53502184 125 + 2.735 2.738 0.010
ENSG00000139546 E038 20.6928435 0.0108347313 1.383760e-13 3.853434e-12 12 53502185 53502602 418 + 1.663 1.016 -2.265
ENSG00000139546 E039 21.5525887 0.0008768089 3.435488e-19 1.999517e-17 12 53502603 53503026 424 + 1.685 1.030 -2.288
ENSG00000139546 E040 615.5944644 0.0002557256 3.247527e-02 7.676420e-02 12 53503027 53503129 103 + 2.647 2.695 0.161
ENSG00000139546 E041 51.9733396 0.0005081650 5.103725e-21 3.690402e-19 12 53503130 53503212 83 + 1.950 1.479 -1.598
ENSG00000139546 E042 43.1762570 0.0040069813 4.962038e-27 6.425450e-25 12 53503213 53503458 246 + 1.965 1.316 -2.210
ENSG00000139546 E043 21.4614075 0.0015580881 4.337174e-14 1.298459e-12 12 53503459 53503473 15 + 1.633 1.065 -1.986
ENSG00000139546 E044 46.2250609 0.0004555355 5.129363e-38 1.559779e-35 12 53503474 53503712 239 + 2.005 1.343 -2.254
ENSG00000139546 E045 258.6642933 0.0001717397 6.363367e-02 1.327505e-01 12 53503713 53503713 1 + 2.263 2.323 0.198
ENSG00000139546 E046 281.3198855 0.0001823081 2.941231e-02 7.079606e-02 12 53503714 53503729 16 + 2.294 2.360 0.221
ENSG00000139546 E047 459.6359938 0.0002585098 5.725846e-02 1.219129e-01 12 53503730 53503808 79 + 2.521 2.570 0.163
ENSG00000139546 E048 104.8228084 0.0015255806 2.214433e-23 2.041449e-21 12 53503809 53504396 588 + 2.206 1.812 -1.322
ENSG00000139546 E049 472.6077121 0.0016668184 1.058634e-01 1.994006e-01 12 53504397 53504469 73 + 2.530 2.585 0.184
ENSG00000139546 E050 37.7104698 0.0110841920 2.005677e-04 9.662782e-04 12 53504612 53504697 86 + 1.706 1.420 -0.975
ENSG00000139546 E051 700.9474899 0.0025492017 2.280665e-01 3.601142e-01 12 53504698 53504815 118 + 2.710 2.754 0.149
ENSG00000139546 E052 573.0031765 0.0005964617 1.122234e-02 3.169975e-02 12 53505135 53505262 128 + 2.607 2.670 0.210
ENSG00000139546 E053 1059.0710390 0.0001642846 1.452086e-11 2.945009e-10 12 53505649 53505850 202 + 2.836 2.942 0.351
ENSG00000139546 E054 6.7978663 0.0062980735 4.687467e-01 6.081217e-01 12 53505851 53505851 1 + 0.881 0.787 -0.367
ENSG00000139546 E055 1240.4294098 0.0028371137 1.098116e-05 7.227699e-05 12 53505991 53506431 441 + 2.888 3.016 0.425