ENSG00000139514

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380752 ENSG00000139514 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A1 protein_coding protein_coding 45.04721 44.29526 30.68698 3.470992 0.06019827 -0.5293813 41.565065 43.0285806 26.214415 3.2463706 0.5779451 -0.7147199 0.9159083 0.9718667 0.85430000 -0.11756667 2.882021e-09 2.882021e-09 FALSE TRUE
MSTRG.8545.2 ENSG00000139514 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC7A1 protein_coding   45.04721 44.29526 30.68698 3.470992 0.06019827 -0.5293813 1.813171 0.5669491 2.466879 0.2311454 0.2109635 2.1020076 0.0432875 0.0122000 0.08036667 0.06816667 2.534808e-06 2.882021e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139514 E001 712.198785 0.0129149628 9.538799e-17 4.117873e-15 13 29509414 29509777 364 - 2.400 3.020 2.064
ENSG00000139514 E002 5634.382095 0.0023153872 5.584743e-22 4.439836e-20 13 29509778 29514583 4806 - 3.582 3.839 0.853
ENSG00000139514 E003 3.254739 0.1512380962 9.259011e-01 9.573483e-01 13 29516047 29516137 91 - 0.573 0.650 0.338
ENSG00000139514 E004 198.369250 0.0058311068 2.934491e-03 1.007084e-02 13 29516138 29516246 109 - 2.280 2.303 0.074
ENSG00000139514 E005 5.425009 0.0034684790 1.227029e-01 2.238197e-01 13 29516867 29517143 277 - 0.572 0.911 1.385
ENSG00000139514 E006 271.957792 0.0063183159 1.659236e-05 1.048210e-04 13 29517144 29517310 167 - 2.448 2.417 -0.106
ENSG00000139514 E007 358.489883 0.0026227401 5.719433e-16 2.231780e-14 13 29517573 29517790 218 - 2.601 2.507 -0.313
ENSG00000139514 E008 223.323965 0.0085037104 6.018593e-06 4.208017e-05 13 29519447 29519549 103 - 2.384 2.313 -0.236
ENSG00000139514 E009 260.321817 0.0018902308 3.106628e-17 1.423046e-15 13 29522317 29522456 140 - 2.465 2.362 -0.343
ENSG00000139514 E010 303.684290 0.0001826143 7.744423e-30 1.284727e-27 13 29523266 29523488 223 - 2.525 2.439 -0.289
ENSG00000139514 E011 220.359725 0.0056935242 3.964121e-07 3.575976e-06 13 29524132 29524253 122 - 2.376 2.311 -0.218
ENSG00000139514 E012 285.230968 0.0051947696 1.992890e-11 3.950064e-10 13 29530538 29530712 175 - 2.513 2.398 -0.384
ENSG00000139514 E013 271.634080 0.0030326929 1.026451e-19 6.315625e-18 13 29532824 29532982 159 - 2.511 2.356 -0.516
ENSG00000139514 E014 110.052161 0.0083463000 1.047302e-06 8.653908e-06 13 29535819 29535823 5 - 2.103 1.981 -0.411
ENSG00000139514 E015 365.486229 0.0090018824 9.151261e-09 1.136541e-07 13 29535824 29536202 379 - 2.624 2.503 -0.403
ENSG00000139514 E016 141.937157 0.0152572895 2.305254e-06 1.769544e-05 13 29553761 29553860 100 - 2.231 2.078 -0.511
ENSG00000139514 E017 0.000000       13 29586725 29586792 68 -      
ENSG00000139514 E018 18.522533 0.0044841267 1.105844e-07 1.114533e-06 13 29595144 29595415 272 - 1.431 1.128 -1.063
ENSG00000139514 E019 87.303445 0.0206019133 2.100175e-05 1.296267e-04 13 29595416 29595621 206 - 2.030 1.857 -0.581
ENSG00000139514 E020 14.027149 0.0019672652 6.619369e-03 2.023885e-02 13 29595622 29595770 149 - 1.223 1.118 -0.376