ENSG00000139505

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381801 ENSG00000139505 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR6 protein_coding protein_coding 6.176888 0.9787846 10.6981 0.1516528 0.5162833 3.436902 3.240450 0.9787846 5.639590 0.1516528 0.2403798 2.514418 0.7026042 1 0.5275667 -0.4724333 2.638901e-17 2.638901e-17 FALSE TRUE
MSTRG.8494.2 ENSG00000139505 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR6 protein_coding   6.176888 0.9787846 10.6981 0.1516528 0.5162833 3.436902 2.924541 0.0000000 5.058508 0.0000000 0.3090241 8.985417 0.2963792 0 0.4724333 0.4724333 2.660194e-17 2.638901e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139505 E001 222.36659 0.0391686172 5.799694e-08 6.161935e-07 13 25246222 25249074 2853 - 2.006 2.579 1.914
ENSG00000139505 E002 78.28137 0.0003670559 6.442100e-02 1.340727e-01 13 25249075 25249492 418 - 1.640 1.714 0.249
ENSG00000139505 E003 31.06240 0.0067900816 8.156990e-02 1.620084e-01 13 25251649 25251775 127 - 1.261 1.244 -0.059
ENSG00000139505 E004 43.45374 0.0005583740 2.749883e-02 6.700412e-02 13 25251853 25251984 132 - 1.401 1.391 -0.035
ENSG00000139505 E005 59.14330 0.0005926607 8.362429e-03 2.469504e-02 13 25253764 25253964 201 - 1.531 1.516 -0.050
ENSG00000139505 E006 21.63975 0.0008777734 6.527175e-02 1.354905e-01 13 25254385 25254434 50 - 1.118 1.065 -0.192
ENSG00000139505 E007 40.81638 0.0052373084 1.417912e-01 2.504982e-01 13 25257196 25257321 126 - 1.370 1.411 0.143
ENSG00000139505 E008 46.31397 0.0005546840 3.131650e-02 7.451509e-02 13 25257736 25257845 110 - 1.428 1.430 0.009
ENSG00000139505 E009 32.62249 0.0006586479 4.811878e-01 6.194324e-01 13 25258560 25258620 61 - 1.272 1.391 0.414
ENSG00000139505 E010 34.75215 0.0006003884 1.311932e-01 2.358190e-01 13 25258621 25258692 72 - 1.306 1.347 0.143
ENSG00000139505 E011 0.00000       13 25260574 25260687 114 -      
ENSG00000139505 E012 40.94051 0.0005691490 1.877725e-02 4.884773e-02 13 25261668 25261802 135 - 1.378 1.347 -0.110
ENSG00000139505 E013 0.00000       13 25261803 25261808 6 -      
ENSG00000139505 E014 36.59673 0.0015221651 6.711936e-03 2.047495e-02 13 25265819 25265947 129 - 1.337 1.243 -0.330
ENSG00000139505 E015 48.59785 0.0005855699 9.693582e-04 3.853734e-03 13 25266129 25266286 158 - 1.456 1.347 -0.378
ENSG00000139505 E016 48.74958 0.0005600735 2.409231e-06 1.841523e-05 13 25267779 25267941 163 - 1.465 1.180 -0.995
ENSG00000139505 E017 36.91797 0.0071289279 1.284339e-04 6.520546e-04 13 25274071 25274187 117 - 1.350 1.065 -1.008
ENSG00000139505 E018 32.75888 0.0146269056 2.272122e-04 1.080032e-03 13 25287224 25287488 265 - 1.303 0.967 -1.209