ENSG00000139496

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381736 ENSG00000139496 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP58 protein_coding protein_coding 18.35985 6.869634 33.92037 1.346424 1.132998 2.302173 14.2233094 3.457727 28.10401489 0.07513575 0.86810136 3.019227 0.7108375 0.5377333 0.8287000000 0.2909667 3.354777e-03 1.973776e-14 FALSE TRUE
ENST00000695578 ENSG00000139496 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP58 protein_coding protein_coding 18.35985 6.869634 33.92037 1.346424 1.132998 2.302173 0.7543448 2.794787 0.01926678 1.27203605 0.01926678 -6.582483 0.1117583 0.3687333 0.0005333333 -0.3682000 1.973776e-14 1.973776e-14   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139496 E001 0.4482035 0.0294999161 1.000000e+00 1.000000e+00 13 25301152 25301152 1 + 0.133 0.000 -8.989
ENSG00000139496 E002 0.4482035 0.0294999161 1.000000e+00 1.000000e+00 13 25301153 25301183 31 + 0.133 0.000 -10.899
ENSG00000139496 E003 0.8857980 0.0136968632 4.091745e-01 5.527917e-01 13 25301184 25301523 340 + 0.235 0.000 -12.079
ENSG00000139496 E004 2.0368459 0.0071094602 4.008896e-01 5.445622e-01 13 25301524 25301573 50 + 0.342 0.563 1.150
ENSG00000139496 E005 3.5054110 0.0043896636 8.676676e-01 9.188875e-01 13 25301574 25301624 51 + 0.531 0.563 0.150
ENSG00000139496 E006 3.8073977 0.0041236471 3.393370e-01 4.832436e-01 13 25301625 25301630 6 + 0.574 0.443 -0.636
ENSG00000139496 E007 3.9514245 0.0039180193 6.854137e-01 7.881612e-01 13 25301631 25301632 2 + 0.574 0.563 -0.051
ENSG00000139496 E008 10.1933974 0.0019338218 7.864130e-02 1.573250e-01 13 25301633 25301636 4 + 0.931 0.734 -0.768
ENSG00000139496 E009 18.5414431 0.0009581879 3.787229e-02 8.711182e-02 13 25301637 25301644 8 + 1.162 0.994 -0.611
ENSG00000139496 E010 19.8589853 0.0009128543 1.792983e-02 4.698591e-02 13 25301645 25301646 2 + 1.193 0.993 -0.722
ENSG00000139496 E011 127.6740555 0.0020798449 1.394611e-05 8.960955e-05 13 25301647 25301880 234 + 1.972 1.828 -0.482
ENSG00000139496 E012 1.4737619 0.0091857037 7.016131e-01 8.006994e-01 13 25302927 25303008 82 + 0.317 0.275 -0.284
ENSG00000139496 E013 2.7324187 0.0056633793 3.722528e-01 5.167028e-01 13 25303102 25303155 54 + 0.427 0.657 1.079
ENSG00000139496 E014 3.1108047 0.0377712708 4.911984e-01 6.284981e-01 13 25307234 25307603 370 + 0.465 0.658 0.888
ENSG00000139496 E015 1.6327659 0.0087913060 1.384852e-01 2.459903e-01 13 25307604 25307640 37 + 0.365 0.000 -12.972
ENSG00000139496 E016 61.5542731 0.0006206043 2.280575e-04 1.083504e-03 13 25307806 25307821 16 + 1.664 1.493 -0.584
ENSG00000139496 E017 124.0362846 0.0021566065 1.575825e-06 1.253427e-05 13 25307822 25307948 127 + 1.962 1.786 -0.591
ENSG00000139496 E018 0.8094222 0.2391272396 2.088158e-01 3.370905e-01 13 25307949 25308137 189 + 0.133 0.444 2.308
ENSG00000139496 E019 76.8665933 0.0011202679 6.967001e-06 4.800601e-05 13 25309247 25309282 36 + 1.759 1.551 -0.710
ENSG00000139496 E020 0.3666179 0.0302220685 1.901466e-01 3.139656e-01 13 25309283 25309429 147 + 0.049 0.276 2.890
ENSG00000139496 E021 0.8491631 0.0165137219 1.590349e-01 2.738348e-01 13 25309960 25310015 56 + 0.133 0.443 2.304
ENSG00000139496 E022 144.0431828 0.0022241382 7.373734e-07 6.303843e-06 13 25312883 25313032 150 + 2.025 1.856 -0.568
ENSG00000139496 E023 71.1965489 0.0005038681 4.583904e-04 2.000154e-03 13 25313614 25313622 9 + 1.720 1.582 -0.469
ENSG00000139496 E024 140.9417842 0.0052060462 7.062501e-04 2.921012e-03 13 25313623 25313737 115 + 2.010 1.897 -0.378
ENSG00000139496 E025 94.0961374 0.0005492994 5.301044e-03 1.675062e-02 13 25313738 25313751 14 + 1.830 1.767 -0.212
ENSG00000139496 E026 92.1866445 0.0003744032 1.336140e-02 3.676030e-02 13 25315357 25315382 26 + 1.819 1.774 -0.151
ENSG00000139496 E027 122.9340191 0.0003400183 9.918952e-02 1.892439e-01 13 25315383 25315467 85 + 1.934 1.948 0.047
ENSG00000139496 E028 1.2449403 0.0203246084 4.248918e-01 5.678369e-01 13 25317691 25317832 142 + 0.235 0.443 1.303
ENSG00000139496 E029 14.4909572 0.0012353046 1.221999e-02 3.405973e-02 13 25317877 25319325 1449 + 1.075 0.800 -1.036
ENSG00000139496 E030 92.1073667 0.0003090588 4.011633e-03 1.317532e-02 13 25319326 25319350 25 + 1.822 1.754 -0.228
ENSG00000139496 E031 17.7509474 0.0010027312 5.571388e-02 1.192020e-01 13 25319351 25320529 1179 + 1.144 0.993 -0.546
ENSG00000139496 E032 92.0051967 0.0003221623 4.022041e-03 1.320332e-02 13 25320530 25320595 66 + 1.822 1.754 -0.229
ENSG00000139496 E033 142.8747995 0.0002627101 6.826674e-05 3.717855e-04 13 25320919 25321093 175 + 2.013 1.925 -0.293
ENSG00000139496 E034 0.0000000       13 25324971 25324988 18 +      
ENSG00000139496 E035 98.2896360 0.0016722225 3.249975e-03 1.100148e-02 13 25324989 25325068 80 + 1.852 1.774 -0.263
ENSG00000139496 E036 0.2903454 0.2916341789 1.000000e+00   13 25325069 25325678 610 + 0.093 0.000 -9.477
ENSG00000139496 E037 0.2924217 0.0290785164 1.000000e+00   13 25326173 25326232 60 + 0.093 0.000 -10.330
ENSG00000139496 E038 133.1440067 0.0038574288 4.108444e-02 9.303852e-02 13 25326916 25327034 119 + 1.975 1.948 -0.091
ENSG00000139496 E039 125.1373046 0.0003401340 4.170444e-02 9.419597e-02 13 25327430 25327512 83 + 1.946 1.943 -0.010
ENSG00000139496 E040 200.3044457 0.0002150450 7.762006e-04 3.173534e-03 13 25331357 25331558 202 + 2.152 2.120 -0.106
ENSG00000139496 E041 13.8708523 0.0187484407 8.454540e-02 1.666688e-01 13 25331559 25331985 427 + 1.048 0.858 -0.714
ENSG00000139496 E042 107.6173202 0.0058206570 5.712301e-01 6.975585e-01 13 25331986 25336212 4227 + 1.873 1.928 0.184
ENSG00000139496 E043 5.8762171 0.0371392985 1.664408e-02 4.415526e-02 13 25336213 25336344 132 + 0.614 1.090 1.861
ENSG00000139496 E044 147.6575166 0.0002242043 1.580566e-03 5.895752e-03 13 25336936 25337034 99 + 2.022 1.977 -0.150
ENSG00000139496 E045 154.4582034 0.0002366423 1.811364e-02 4.737453e-02 13 25338636 25338731 96 + 2.037 2.030 -0.022
ENSG00000139496 E046 4.0570587 0.0157693032 7.770669e-02 1.557809e-01 13 25338732 25338878 147 + 0.614 0.276 -1.811
ENSG00000139496 E047 1.9271622 0.0070776960 9.140831e-01 9.495743e-01 13 25339189 25339251 63 + 0.365 0.442 0.426
ENSG00000139496 E048 489.1815069 0.0001126835 1.386859e-02 3.792875e-02 13 25339965 25340847 883 + 2.512 2.652 0.466
ENSG00000139496 E049 125.8869597 0.0012983505 8.813822e-08 9.041816e-07 13 25340848 25341033 186 + 1.892 2.201 1.036
ENSG00000139496 E050 591.1914704 0.0194488978 2.265975e-09 3.144924e-08 13 25341034 25342432 1399 + 2.518 2.965 1.488
ENSG00000139496 E051 0.1472490 0.0434205966 1.000000e+00   13 25349562 25349963 402 + 0.049 0.000 -9.196
ENSG00000139496 E052 0.1472490 0.0434205966 1.000000e+00   13 25350131 25350239 109 + 0.049 0.000 -9.196
ENSG00000139496 E053 0.0000000       13 25352519 25352710 192 +      
ENSG00000139496 E054 0.0000000       13 25365330 25365390 61 +