ENSG00000139437

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000405876 ENSG00000139437 HEK293_OSMI2_2hA HEK293_TMG_2hB TCHP protein_coding protein_coding 9.508997 9.078086 9.570836 0.506934 0.491763 0.07617505 7.2455319 6.903781 7.0410419 0.7408016 0.06401732 0.02836155 0.76338750 0.7686 0.73970000 -0.02890000 8.635729e-01 1.760745e-06 FALSE  
ENST00000549550 ENSG00000139437 HEK293_OSMI2_2hA HEK293_TMG_2hB TCHP protein_coding retained_intron 9.508997 9.078086 9.570836 0.506934 0.491763 0.07617505 0.5277089 0.000000 0.8177828 0.0000000 0.33461261 6.37118031 0.05320000 0.0000 0.08256667 0.08256667 1.760745e-06 1.760745e-06 FALSE  
ENST00000551627 ENSG00000139437 HEK293_OSMI2_2hA HEK293_TMG_2hB TCHP protein_coding retained_intron 9.508997 9.078086 9.570836 0.506934 0.491763 0.07617505 0.6025013 1.672439 0.3796445 0.9799805 0.11619885 -2.11032421 0.06305417 0.1762 0.03873333 -0.13746667 7.514539e-01 1.760745e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139437 E001 2.2841239 0.0067244314 0.4283646994 0.5711511160 12 109900264 109900273 10 + 0.433 0.578 0.700
ENSG00000139437 E002 34.6253899 0.0006622623 0.3376237318 0.4815131788 12 109900274 109900426 153 + 1.503 1.578 0.256
ENSG00000139437 E003 0.6060617 0.9044909278 0.2885171861 0.4291232471 12 109900518 109900608 91 + 0.378 0.000 -12.155
ENSG00000139437 E004 1.9378705 0.1399618159 0.1248038337 0.2268504200 12 109900609 109900731 123 + 0.612 0.287 -1.721
ENSG00000139437 E005 2.4787042 0.0063777546 0.2987017782 0.4401589553 12 109900732 109901059 328 + 0.611 0.456 -0.731
ENSG00000139437 E006 59.2310237 0.0004520637 0.9180809877 0.9522301242 12 109903027 109903214 188 + 1.762 1.785 0.078
ENSG00000139437 E007 80.0088154 0.0003579373 0.0001136286 0.0005844853 12 109903937 109904147 211 + 1.974 1.845 -0.434
ENSG00000139437 E008 47.1468288 0.0005361262 0.0000252390 0.0001528648 12 109904737 109904793 57 + 1.782 1.591 -0.648
ENSG00000139437 E009 1.8152990 0.0131246567 0.1645130018 0.2810425503 12 109904794 109905027 234 + 0.573 0.349 -1.150
ENSG00000139437 E010 45.2600249 0.0067427479 0.0038318910 0.0126706623 12 109906572 109906640 69 + 1.752 1.589 -0.552
ENSG00000139437 E011 76.5748802 0.0003435726 0.2598499911 0.3973156090 12 109907526 109907699 174 + 1.902 1.876 -0.086
ENSG00000139437 E012 67.6207639 0.0077188621 0.5301325046 0.6627973316 12 109908586 109908698 113 + 1.842 1.821 -0.070
ENSG00000139437 E013 1.9593258 0.0099896160 0.2782268171 0.4178729144 12 109908815 109908870 56 + 0.573 0.405 -0.828
ENSG00000139437 E014 49.5855976 0.0004885147 0.1680131507 0.2856169842 12 109908871 109908937 67 + 1.727 1.678 -0.166
ENSG00000139437 E015 66.4351691 0.0004781789 0.5481167077 0.6779998428 12 109911063 109911235 173 + 1.827 1.819 -0.025
ENSG00000139437 E016 1.4467039 0.0093332705 0.5852993037 0.7090171826 12 109912973 109912990 18 + 0.433 0.350 -0.470
ENSG00000139437 E017 56.0818922 0.0007786656 0.7323491787 0.8238129633 12 109912991 109913072 82 + 1.749 1.751 0.007
ENSG00000139437 E018 3.6171830 0.0045336867 0.0082494187 0.0244165110 12 109914206 109914441 236 + 0.834 0.456 -1.649
ENSG00000139437 E019 81.5161732 0.0003871372 0.3043644048 0.4463679837 12 109914442 109914627 186 + 1.877 1.935 0.195
ENSG00000139437 E020 7.6811039 0.0022585679 0.1013654408 0.1925517508 12 109914628 109915402 775 + 1.025 0.856 -0.633
ENSG00000139437 E021 63.2352024 0.0010269852 0.0476508460 0.1049992419 12 109915403 109915546 144 + 1.738 1.847 0.366
ENSG00000139437 E022 54.2927269 0.0005277246 0.0030505550 0.0104148222 12 109916591 109916710 120 + 1.641 1.802 0.545
ENSG00000139437 E023 315.9771549 0.0054652821 0.0028458118 0.0098116494 12 109916711 109918069 1359 + 2.430 2.543 0.380
ENSG00000139437 E024 0.0000000       12 109929845 109932017 2173 +      
ENSG00000139437 E025 0.4407149 0.0212820655 0.4865150116 0.6242422998 12 109932897 109933043 147 + 0.227 0.117 -1.149
ENSG00000139437 E026 0.1482932 0.0410875705 0.5519896544   12 109933044 109933084 41 + 0.000 0.117 10.474
ENSG00000139437 E027 0.0000000       12 109933085 109934151 1067 +      
ENSG00000139437 E028 0.1451727 0.0427627214 0.4318325813   12 109953118 109953269 152 + 0.128 0.000 -11.482
ENSG00000139437 E029 0.0000000       12 109980905 109981179 275 +      
ENSG00000139437 E030 0.0000000       12 109983610 109983841 232 +