ENSG00000139436

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355312 ENSG00000139436 HEK293_OSMI2_2hA HEK293_TMG_2hB GIT2 protein_coding protein_coding 11.12295 8.078084 12.06264 0.4741565 0.6588254 0.5778716 4.2398566 5.7516252 4.851652 0.78628356 0.16882994 -0.2450291 0.40726250 0.70690000 0.4052667 -0.30163333 3.913956e-03 2.632974e-12 FALSE TRUE
ENST00000361006 ENSG00000139436 HEK293_OSMI2_2hA HEK293_TMG_2hB GIT2 protein_coding protein_coding 11.12295 8.078084 12.06264 0.4741565 0.6588254 0.5778716 1.7935636 0.4270780 1.463635 0.42707796 0.16103871 1.7534166 0.15607083 0.05870000 0.1210000 0.06230000 2.287928e-01 2.632974e-12 FALSE TRUE
ENST00000457474 ENSG00000139436 HEK293_OSMI2_2hA HEK293_TMG_2hB GIT2 protein_coding protein_coding 11.12295 8.078084 12.06264 0.4741565 0.6588254 0.5778716 0.3750218 0.6863286 0.000000 0.58200175 0.00000000 -6.1216965 0.04207083 0.08633333 0.0000000 -0.08633333 1.909864e-01 2.632974e-12 FALSE TRUE
ENST00000550480 ENSG00000139436 HEK293_OSMI2_2hA HEK293_TMG_2hB GIT2 protein_coding retained_intron 11.12295 8.078084 12.06264 0.4741565 0.6588254 0.5778716 0.8718161 0.3108293 1.050315 0.10024751 0.16164412 1.7246159 0.07510833 0.03756667 0.0865000 0.04893333 8.604183e-02 2.632974e-12   FALSE
ENST00000551209 ENSG00000139436 HEK293_OSMI2_2hA HEK293_TMG_2hB GIT2 protein_coding protein_coding 11.12295 8.078084 12.06264 0.4741565 0.6588254 0.5778716 0.9079561 0.1002282 1.890139 0.01201932 0.07647838 4.1075403 0.07416667 0.01266667 0.1584333 0.14576667 2.632974e-12 2.632974e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139436 E001 272.1276730 0.0092657194 1.902037e-15 6.936192e-14 12 109929804 109930786 983 - 2.177 2.594 1.390
ENSG00000139436 E002 65.6306840 0.0003975583 5.282183e-07 4.650712e-06 12 109930787 109930875 89 - 1.677 1.927 0.845
ENSG00000139436 E003 59.3614636 0.0004405492 2.665896e-04 1.243557e-03 12 109930876 109930950 75 - 1.668 1.865 0.665
ENSG00000139436 E004 89.4115893 0.0020194309 3.476149e-05 2.033742e-04 12 109930951 109931153 203 - 1.836 2.042 0.689
ENSG00000139436 E005 230.2802230 0.0002144588 4.833557e-07 4.285995e-06 12 109931154 109932254 1101 - 2.283 2.428 0.485
ENSG00000139436 E006 43.5175243 0.0004882481 5.075520e-01 6.430343e-01 12 109932255 109932316 62 - 1.614 1.678 0.217
ENSG00000139436 E007 72.0382864 0.0003816716 3.965161e-01 5.402675e-01 12 109932317 109932614 298 - 1.833 1.897 0.216
ENSG00000139436 E008 89.0075940 0.0009557677 3.951819e-01 5.390111e-01 12 109932615 109932972 358 - 1.923 1.985 0.210
ENSG00000139436 E009 32.4374421 0.0042237075 5.442992e-02 1.170069e-01 12 109932973 109932977 5 - 1.571 1.469 -0.348
ENSG00000139436 E010 47.1800170 0.0034964550 3.112984e-01 4.537446e-01 12 109932978 109933037 60 - 1.695 1.666 -0.100
ENSG00000139436 E011 31.6192160 0.0008576781 7.771598e-01 8.565890e-01 12 109933038 109933056 19 - 1.506 1.518 0.038
ENSG00000139436 E012 39.2660996 0.0017616819 9.510773e-01 9.733972e-01 12 109933057 109933095 39 - 1.585 1.617 0.110
ENSG00000139436 E013 32.1638701 0.0098532392 3.092561e-01 4.515251e-01 12 109933096 109933111 16 - 1.459 1.564 0.360
ENSG00000139436 E014 44.4496691 0.0030808816 8.847782e-01 9.303356e-01 12 109933112 109933190 79 - 1.633 1.670 0.125
ENSG00000139436 E015 27.8826873 0.0007229353 7.094216e-01 8.068145e-01 12 109934022 109934036 15 - 1.459 1.463 0.015
ENSG00000139436 E016 24.7784553 0.0009786152 9.521131e-01 9.740209e-01 12 109934037 109934039 3 - 1.401 1.425 0.085
ENSG00000139436 E017 35.6747978 0.0043108629 8.472510e-01 9.051183e-01 12 109934040 109934085 46 - 1.557 1.574 0.059
ENSG00000139436 E018 67.2838947 0.0004073539 1.368588e-02 3.750555e-02 12 109938380 109938534 155 - 1.871 1.795 -0.257
ENSG00000139436 E019 39.8641668 0.0006945017 2.500412e-02 6.188161e-02 12 109938535 109938568 34 - 1.657 1.562 -0.324
ENSG00000139436 E020 3.3289140 0.0046930608 7.455696e-02 1.508284e-01 12 109938569 109938808 240 - 0.743 0.492 -1.105
ENSG00000139436 E021 3.0730119 0.1338298636 1.756318e-01 2.955097e-01 12 109938809 109939022 214 - 0.719 0.446 -1.243
ENSG00000139436 E022 55.3644279 0.0004033999 1.982813e-03 7.173183e-03 12 109939165 109939239 75 - 1.807 1.691 -0.393
ENSG00000139436 E023 34.2091237 0.0080323932 5.529051e-02 1.184939e-01 12 109939240 109939247 8 - 1.598 1.485 -0.389
ENSG00000139436 E024 7.6250211 0.0033205809 1.586375e-02 4.243092e-02 12 109939248 109939685 438 - 1.052 0.797 -0.965
ENSG00000139436 E025 9.7758041 0.0027313438 6.899541e-03 2.096354e-02 12 109939754 109940501 748 - 1.146 0.885 -0.962
ENSG00000139436 E026 4.5314604 0.0288966449 2.128688e-03 7.623464e-03 12 109942842 109943021 180 - 0.917 0.441 -2.044
ENSG00000139436 E027 38.7799394 0.0005790308 2.523281e-02 6.235447e-02 12 109945260 109945349 90 - 1.645 1.549 -0.328
ENSG00000139436 E028 36.6130312 0.0010486925 9.025884e-04 3.622726e-03 12 109947256 109947321 66 - 1.654 1.489 -0.564
ENSG00000139436 E029 63.1029620 0.0118799076 3.535891e-03 1.182899e-02 12 109947322 109947504 183 - 1.888 1.719 -0.571
ENSG00000139436 E030 0.2944980 0.3573046038 3.167695e-01   12 109947505 109948061 557 - 0.205 0.000 -11.054
ENSG00000139436 E031 10.6305346 0.0016771979 9.337214e-01 9.622412e-01 12 109948062 109948846 785 - 1.052 1.087 0.129
ENSG00000139436 E032 0.7447779 0.0575467495 2.581744e-02 6.356370e-02 12 109950694 109951166 473 - 0.400 0.000 -14.164
ENSG00000139436 E033 34.2653435 0.0026529487 9.221382e-04 3.692510e-03 12 109951167 109951211 45 - 1.630 1.447 -0.625
ENSG00000139436 E034 50.4437566 0.0098718694 1.668250e-01 2.840496e-01 12 109951212 109951316 105 - 1.743 1.674 -0.236
ENSG00000139436 E035 0.1472490 0.0431104906 5.293844e-01   12 109952680 109953091 412 - 0.115 0.000 -12.071
ENSG00000139436 E036 75.7112884 0.0003884296 1.286019e-03 4.930233e-03 12 109953092 109953234 143 - 1.935 1.835 -0.338
ENSG00000139436 E037 0.6590396 0.0269982021 3.580585e-01 5.024485e-01 12 109953235 109954550 1316 - 0.280 0.131 -1.365
ENSG00000139436 E038 65.6060553 0.0003533681 1.812600e-05 1.135629e-04 12 109959847 109959958 112 - 1.897 1.741 -0.528
ENSG00000139436 E039 58.0304497 0.0004037543 1.138858e-03 4.433436e-03 12 109961278 109961375 98 - 1.827 1.706 -0.408
ENSG00000139436 E040 36.3834006 0.0005709974 1.546162e-02 4.154068e-02 12 109961613 109961650 38 - 1.624 1.513 -0.379
ENSG00000139436 E041 32.2408242 0.0006364215 5.178714e-02 1.123392e-01 12 109961651 109961685 35 - 1.564 1.474 -0.308
ENSG00000139436 E042 30.3221352 0.0006941815 1.259445e-01 2.284984e-01 12 109965526 109965574 49 - 1.530 1.463 -0.230
ENSG00000139436 E043 14.1327575 0.0012738689 9.528935e-01 9.745137e-01 12 109965575 109965577 3 - 1.164 1.197 0.117
ENSG00000139436 E044 0.2998086 0.0292630033 9.549964e-01   12 109967314 109967319 6 - 0.115 0.130 0.214
ENSG00000139436 E045 32.4349706 0.0006603437 1.134622e-03 4.419761e-03 12 109967458 109967503 46 - 1.601 1.431 -0.585
ENSG00000139436 E046 48.2090688 0.0004702314 1.031909e-02 2.955418e-02 12 109980952 109981046 95 - 1.738 1.638 -0.340
ENSG00000139436 E047 0.1451727 0.0435282133 5.291217e-01   12 109981047 109983180 2134 - 0.115 0.000 -12.065
ENSG00000139436 E048 64.9643680 0.0004354907 4.073667e-02 9.239014e-02 12 109983373 109983503 131 - 1.848 1.788 -0.202
ENSG00000139436 E049 51.2625249 0.0041495479 3.321211e-01 4.757499e-01 12 109983608 109983694 87 - 1.729 1.701 -0.093
ENSG00000139436 E050 52.7804517 0.0004646580 3.342524e-03 1.126966e-02 12 109988963 109989068 106 - 1.782 1.669 -0.382
ENSG00000139436 E051 47.9828833 0.0006480113 6.492559e-04 2.713366e-03 12 109989690 109989802 113 - 1.755 1.609 -0.494
ENSG00000139436 E052 40.8642985 0.0005406466 4.594884e-04 2.004345e-03 12 109991627 109991760 134 - 1.698 1.536 -0.553
ENSG00000139436 E053 0.1817044 0.0396445230 4.498006e-01   12 109991761 109992088 328 - 0.000 0.131 11.961
ENSG00000139436 E054 0.5943067 0.0213831994 3.538013e-01 4.980686e-01 12 109996099 109996172 74 - 0.280 0.130 -1.370
ENSG00000139436 E055 26.1600389 0.0127822686 2.450031e-01 3.800374e-01 12 109996173 109996389 217 - 1.472 1.400 -0.249