ENSG00000139324

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000266712 ENSG00000139324 HEK293_OSMI2_2hA HEK293_TMG_2hB TMTC3 protein_coding protein_coding 9.062007 1.066227 15.3005 0.1773309 0.4328627 3.830467 6.8927601 0.3453866 11.2512372 0.1281973 0.2551902 4.985832 0.78111667 0.3506667 0.73566667 0.38500000 0.0719176496 0.0003510726 FALSE TRUE
ENST00000547034 ENSG00000139324 HEK293_OSMI2_2hA HEK293_TMG_2hB TMTC3 protein_coding nonsense_mediated_decay 9.062007 1.066227 15.3005 0.1773309 0.4328627 3.830467 0.7113983 0.0000000 0.8308759 0.0000000 0.4807065 6.393821 0.04466667 0.0000000 0.05576667 0.05576667 0.6661069643 0.0003510726 TRUE TRUE
ENST00000549011 ENSG00000139324 HEK293_OSMI2_2hA HEK293_TMG_2hB TMTC3 protein_coding protein_coding 9.062007 1.066227 15.3005 0.1773309 0.4328627 3.830467 0.1182748 0.0000000 0.7928131 0.0000000 0.4489856 6.326992 0.00721250 0.0000000 0.05026667 0.05026667 0.6652607078 0.0003510726 FALSE FALSE
ENST00000551088 ENSG00000139324 HEK293_OSMI2_2hA HEK293_TMG_2hB TMTC3 protein_coding protein_coding 9.062007 1.066227 15.3005 0.1773309 0.4328627 3.830467 0.8214472 0.0000000 1.4849082 0.0000000 0.2604313 7.223913 0.05514583 0.0000000 0.09720000 0.09720000 0.0027323772 0.0003510726 FALSE FALSE
MSTRG.7735.6 ENSG00000139324 HEK293_OSMI2_2hA HEK293_TMG_2hB TMTC3 protein_coding   9.062007 1.066227 15.3005 0.1773309 0.4328627 3.830467 0.2056326 0.7208406 0.1934871 0.2266772 0.1066774 -1.844620 0.09398333 0.6493333 0.01306667 -0.63626667 0.0003510726 0.0003510726 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139324 E001 0.4482035 0.0299797785 1.000000e+00 1.000000e+00 12 88142296 88142306 11 + 0.061 0.000 -10.084
ENSG00000139324 E002 0.5997190 0.1706366251 1.000000e+00 1.000000e+00 12 88142307 88142311 5 + 0.080 0.000 -10.497
ENSG00000139324 E003 0.5997190 0.1706366251 1.000000e+00 1.000000e+00 12 88142312 88142316 5 + 0.080 0.000 -10.497
ENSG00000139324 E004 23.1456017 0.0008878964 3.677862e-04 1.649526e-03 12 88142317 88142396 80 + 0.945 0.714 -0.900
ENSG00000139324 E005 34.6550152 0.0006255948 2.501147e-02 6.189711e-02 12 88142397 88142487 91 + 1.090 1.297 0.736
ENSG00000139324 E006 1.4791742 0.0254960442 5.490978e-01 6.788677e-01 12 88142720 88142885 166 + 0.178 0.000 -11.815
ENSG00000139324 E007 68.3643580 0.0003681190 5.304121e-05 2.969941e-04 12 88148288 88148504 217 + 1.372 1.481 0.377
ENSG00000139324 E008 76.3258948 0.0004188231 4.264422e-09 5.623961e-08 12 88153291 88153509 219 + 1.425 1.297 -0.443
ENSG00000139324 E009 56.1254090 0.0004569327 3.230812e-08 3.615071e-07 12 88154288 88154387 100 + 1.299 1.059 -0.854
ENSG00000139324 E010 50.8789152 0.0011409294 6.380425e-08 6.730247e-07 12 88160114 88160229 116 + 1.259 0.971 -1.038
ENSG00000139324 E011 70.5147181 0.0038406651 2.140266e-07 2.040086e-06 12 88160679 88160851 173 + 1.391 1.297 -0.327
ENSG00000139324 E012 95.2396719 0.0003181904 1.122328e-07 1.129885e-06 12 88166330 88166582 253 + 1.512 1.563 0.174
ENSG00000139324 E013 66.5155290 0.0003797056 6.458888e-04 2.701380e-03 12 88172597 88172745 149 + 1.357 1.537 0.622
ENSG00000139324 E014 0.2214452 0.0424586929 1.868757e-02   12 88172746 88172757 12 + 0.000 0.491 18.957
ENSG00000139324 E015 0.2944980 0.3506034756 7.922568e-01   12 88172966 88173089 124 + 0.042 0.000 -9.492
ENSG00000139324 E016 47.8255996 0.0004545385 5.952710e-03 1.848384e-02 12 88174607 88174727 121 + 1.220 1.416 0.685
ENSG00000139324 E017 44.9085799 0.0005085382 2.975142e-04 1.369580e-03 12 88176208 88176319 112 + 1.201 1.249 0.167
ENSG00000139324 E018 45.6499764 0.0008545705 7.497724e-08 7.801940e-07 12 88188843 88188946 104 + 1.217 0.862 -1.305
ENSG00000139324 E019 71.9856396 0.0003465455 1.377209e-10 2.374483e-09 12 88190453 88190622 170 + 1.403 1.132 -0.955
ENSG00000139324 E020 80.6161067 0.0003146017 1.077226e-10 1.891356e-09 12 88192604 88192830 227 + 1.449 1.249 -0.699
ENSG00000139324 E021 696.7085737 0.0840588136 1.628149e-07 1.588382e-06 12 88194838 88199887 5050 + 2.306 3.108 2.671