ENSG00000139263

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320743 ENSG00000139263 HEK293_OSMI2_2hA HEK293_TMG_2hB LRIG3 protein_coding protein_coding 8.382294 2.325164 10.57025 0.1488681 0.5101314 2.179778 4.803039 0.6834525 6.869786 0.1354791 0.4940622 3.3104947 0.5245958 0.3011667 0.6564333 0.3552667 0.0207608906 0.0006382293 FALSE TRUE
ENST00000379141 ENSG00000139263 HEK293_OSMI2_2hA HEK293_TMG_2hB LRIG3 protein_coding protein_coding 8.382294 2.325164 10.57025 0.1488681 0.5101314 2.179778 2.547144 1.5657187 2.069482 0.2966131 0.5790265 0.4002143 0.3570167 0.6649667 0.1929000 -0.4720667 0.0006382293 0.0006382293 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139263 E001 0.2214452 0.0423849770 1.096622e-01   12 58872149 58872154 6 - 0.000 0.216 10.997
ENSG00000139263 E002 34.9266366 0.0071429392 5.283221e-06 3.738991e-05 12 58872155 58872547 393 - 1.386 1.712 1.118
ENSG00000139263 E003 76.0828982 0.0015701584 2.904033e-06 2.179889e-05 12 58872548 58872816 269 - 1.757 1.972 0.724
ENSG00000139263 E004 1.2962207 0.0123715086 2.759616e-01 4.153632e-01 12 58873551 58874052 502 - 0.262 0.466 1.218
ENSG00000139263 E005 0.1472490 0.0435617093 1.000000e+00   12 58874053 58874054 2 - 0.066 0.000 -10.254
ENSG00000139263 E006 87.0050362 0.0004310381 1.643651e-06 1.302211e-05 12 58874055 58874330 276 - 1.824 2.020 0.660
ENSG00000139263 E007 0.6674587 0.0247320948 8.236098e-01 8.888676e-01 12 58874331 58874429 99 - 0.175 0.215 0.372
ENSG00000139263 E008 62.4211936 0.0020685650 2.887864e-03 9.934216e-03 12 58874430 58874573 144 - 1.693 1.850 0.531
ENSG00000139263 E009 63.5584319 0.0035077330 9.180837e-02 1.779517e-01 12 58876445 58876603 159 - 1.719 1.816 0.327
ENSG00000139263 E010 115.8566077 0.0003169100 5.226608e-01 6.564202e-01 12 58877400 58877852 453 - 1.995 2.020 0.084
ENSG00000139263 E011 68.7191042 0.0003825215 4.245941e-01 5.675565e-01 12 58878824 58879105 282 - 1.765 1.805 0.134
ENSG00000139263 E012 0.8836079 0.0132509988 2.077069e-01 3.357200e-01 12 58880360 58880368 9 - 0.299 0.000 -12.751
ENSG00000139263 E013 2.9687300 0.0052792504 4.813640e-03 1.541281e-02 12 58880369 58880478 110 - 0.634 0.000 -14.395
ENSG00000139263 E014 2.0809695 0.0312125771 2.600430e-02 6.395477e-02 12 58880479 58880580 102 - 0.521 0.000 -13.942
ENSG00000139263 E015 69.2564693 0.0004715901 9.784015e-01 9.906458e-01 12 58880581 58880901 321 - 1.778 1.778 -0.002
ENSG00000139263 E016 45.8738676 0.0005836744 3.809181e-01 5.252095e-01 12 58882869 58883032 164 - 1.613 1.559 -0.183
ENSG00000139263 E017 28.5717643 0.0094311227 8.587988e-01 9.129091e-01 12 58883520 58883591 72 - 1.409 1.392 -0.062
ENSG00000139263 E018 24.3690915 0.0034727035 7.718280e-01 8.527220e-01 12 58885831 58885879 49 - 1.333 1.357 0.086
ENSG00000139263 E019 25.7340881 0.0007937453 7.671779e-01 8.494724e-01 12 58885880 58885902 23 - 1.368 1.345 -0.079
ENSG00000139263 E020 35.4545027 0.0005720104 1.469290e-01 2.575002e-01 12 58886810 58886890 81 - 1.517 1.415 -0.353
ENSG00000139263 E021 0.4741261 0.0214300433 5.833009e-01 7.074377e-01 12 58886891 58887035 145 - 0.124 0.215 0.955
ENSG00000139263 E022 48.6914500 0.0004614839 7.182068e-02 1.463758e-01 12 58887789 58887932 144 - 1.653 1.543 -0.373
ENSG00000139263 E023 42.9789097 0.0005774972 6.209166e-01 7.379644e-01 12 58888329 58888472 144 - 1.582 1.551 -0.105
ENSG00000139263 E024 26.1101081 0.0007593099 1.215168e-01 2.220988e-01 12 58888819 58888873 55 - 1.392 1.262 -0.451
ENSG00000139263 E025 38.8571645 0.0005871353 2.845494e-02 6.892161e-02 12 58888874 58888962 89 - 1.567 1.415 -0.522
ENSG00000139263 E026 51.6698924 0.0044794400 2.316317e-04 1.098421e-03 12 58889996 58890139 144 - 1.706 1.444 -0.893
ENSG00000139263 E027 46.7890941 0.0017695137 3.713619e-05 2.157153e-04 12 58890665 58890796 132 - 1.669 1.381 -0.987
ENSG00000139263 E028 0.2955422 0.0285394604 3.234697e-01   12 58913495 58913981 487 - 0.066 0.215 1.952
ENSG00000139263 E029 37.3545675 0.0006119558 1.904681e-04 9.232322e-04 12 58913982 58914056 75 - 1.573 1.292 -0.970
ENSG00000139263 E030 31.1323619 0.0006127516 3.122493e-03 1.062576e-02 12 58914265 58914336 72 - 1.486 1.247 -0.829
ENSG00000139263 E031 0.0000000       12 58914337 58914583 247 -      
ENSG00000139263 E032 0.1451727 0.0442054346 1.000000e+00   12 58919427 58919546 120 - 0.066 0.000 -10.255
ENSG00000139263 E033 38.5345897 0.0018100058 2.850663e-06 2.144160e-05 12 58920000 58920504 505 - 1.593 1.214 -1.312