ENSG00000139220

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000541570 ENSG00000139220 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIA2 protein_coding protein_coding 0.76397 0.602949 1.305023 0.1595337 0.21667 1.10125 0.01968429 0.03250338 0.00000000 0.03250338 0.00000000 -2.0875777 0.05525833 0.03613333 0.00000000 -0.03613333 0.43357630 0.03524649 FALSE TRUE
ENST00000547180 ENSG00000139220 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIA2 protein_coding retained_intron 0.76397 0.602949 1.305023 0.1595337 0.21667 1.10125 0.01390564 0.00000000 0.08310350 0.00000000 0.04245185 3.2188354 0.01872500 0.00000000 0.06313333 0.06313333 0.41291545 0.03524649 FALSE FALSE
ENST00000547273 ENSG00000139220 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIA2 protein_coding processed_transcript 0.76397 0.602949 1.305023 0.1595337 0.21667 1.10125 0.16377723 0.21485571 0.27046276 0.12294069 0.17969398 0.3188097 0.18794583 0.33623333 0.17463333 -0.16160000 0.84604381 0.03524649   FALSE
ENST00000547623 ENSG00000139220 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIA2 protein_coding protein_coding 0.76397 0.602949 1.305023 0.1595337 0.21667 1.10125 0.02917772 0.11099060 0.00000000 0.11099060 0.00000000 -3.5968230 0.05247083 0.12336667 0.00000000 -0.12336667 0.55176857 0.03524649 FALSE FALSE
ENST00000549396 ENSG00000139220 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIA2 protein_coding protein_coding 0.76397 0.602949 1.305023 0.1595337 0.21667 1.10125 0.02224604 0.05098356 0.00000000 0.02869783 0.00000000 -2.6084204 0.03692500 0.07936667 0.00000000 -0.07936667 0.03524649 0.03524649 FALSE TRUE
ENST00000550018 ENSG00000139220 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIA2 protein_coding protein_coding 0.76397 0.602949 1.305023 0.1595337 0.21667 1.10125 0.09932893 0.06489591 0.23989390 0.06489591 0.12428089 1.7383568 0.12337917 0.18386667 0.16620000 -0.01766667 0.79727237 0.03524649 FALSE FALSE
ENST00000550584 ENSG00000139220 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIA2 protein_coding protein_coding 0.76397 0.602949 1.305023 0.1595337 0.21667 1.10125 0.06895687 0.03608645 0.18709689 0.02242073 0.01924116 2.0964903 0.08810000 0.09153333 0.15400000 0.06246667 0.38745372 0.03524649 FALSE TRUE
ENST00000550798 ENSG00000139220 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIA2 protein_coding retained_intron 0.76397 0.602949 1.305023 0.1595337 0.21667 1.10125 0.11813340 0.02703669 0.05752439 0.02703669 0.05752439 0.8664538 0.13273750 0.07660000 0.05696667 -0.01963333 0.92897792 0.03524649 FALSE TRUE
ENST00000551442 ENSG00000139220 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIA2 protein_coding protein_coding 0.76397 0.602949 1.305023 0.1595337 0.21667 1.10125 0.05365919 0.00000000 0.22372322 0.00000000 0.11261462 4.5467292 0.08161667 0.00000000 0.16173333 0.16173333 0.30790226 0.03524649 FALSE FALSE
ENST00000552948 ENSG00000139220 HEK293_OSMI2_2hA HEK293_TMG_2hB PPFIA2 protein_coding protein_coding 0.76397 0.602949 1.305023 0.1595337 0.21667 1.10125 0.03861300 0.00000000 0.07576050 0.00000000 0.03938016 3.1003134 0.04585000 0.00000000 0.06200000 0.06200000 0.44685718 0.03524649 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139220 E001 0.0000000       12 81257975 81258266 292 -      
ENSG00000139220 E002 2.4430157 0.089545956 0.385490056 0.52968221 12 81258267 81258876 610 - 0.476 0.631 0.717
ENSG00000139220 E003 2.0876709 0.072057194 0.031215939 0.07431968 12 81258877 81259100 224 - 0.323 0.681 1.779
ENSG00000139220 E004 0.8772757 0.025514449 0.163025722 0.27908565 12 81259101 81259165 65 - 0.159 0.387 1.699
ENSG00000139220 E005 1.3556682 0.059078446 0.245144677 0.38020404 12 81259166 81259267 102 - 0.275 0.466 1.119
ENSG00000139220 E006 0.6998377 0.016675729 0.392711298 0.53661933 12 81259268 81259396 129 - 0.159 0.292 1.112
ENSG00000139220 E007 0.8878717 0.014460401 0.161485073 0.27704402 12 81259397 81259435 39 - 0.159 0.387 1.697
ENSG00000139220 E008 1.9993813 0.010665094 0.774292570 0.85449305 12 81259436 81259600 165 - 0.443 0.465 0.112
ENSG00000139220 E009 1.9262292 0.019135208 0.776320071 0.85597265 12 81259601 81259660 60 - 0.443 0.464 0.110
ENSG00000139220 E010 0.8179419 0.014956563 0.620662969 0.73776798 12 81261949 81261960 12 - 0.221 0.291 0.525
ENSG00000139220 E011 0.9631146 0.013696863 0.840689984 0.90056361 12 81261961 81261966 6 - 0.276 0.291 0.110
ENSG00000139220 E012 0.9631146 0.013696863 0.840689984 0.90056361 12 81261967 81262040 74 - 0.276 0.291 0.110
ENSG00000139220 E013 2.8203445 0.007781968 0.731909493 0.82347805 12 81263231 81263390 160 - 0.563 0.587 0.109
ENSG00000139220 E014 1.7714796 0.008133366 0.865688673 0.91749439 12 81266952 81267020 69 - 0.443 0.387 -0.304
ENSG00000139220 E015 1.6263069 0.009019304 0.978397428 0.99064580 12 81267912 81268087 176 - 0.407 0.387 -0.111
ENSG00000139220 E016 1.2598027 0.012106939 0.777976532 0.85715771 12 81277317 81277371 55 - 0.367 0.291 -0.475
ENSG00000139220 E017 1.1146300 0.012738820 0.956217796 0.97658119 12 81277372 81277414 43 - 0.324 0.291 -0.212
ENSG00000139220 E018 1.7058162 0.008474489 0.387167970 0.53131168 12 81281257 81281337 81 - 0.476 0.291 -1.060
ENSG00000139220 E019 1.6984293 0.008364372 0.098910742 0.18880894 12 81281338 81281432 95 - 0.507 0.170 -2.211
ENSG00000139220 E020 1.4382729 0.009674758 0.621219616 0.73821339 12 81281433 81281450 18 - 0.407 0.292 -0.696
ENSG00000139220 E021 0.0000000       12 81283010 81283039 30 -      
ENSG00000139220 E022 0.0000000       12 81284241 81284303 63 -      
ENSG00000139220 E023 0.2987644 0.028945877 0.559458800   12 81294582 81294834 253 - 0.159 0.000 -12.210
ENSG00000139220 E024 2.9777112 0.089345493 0.484709446 0.62266822 12 81294835 81295035 201 - 0.635 0.467 -0.782
ENSG00000139220 E025 2.3362889 0.490302665 0.773002656 0.85348716 12 81299301 81299382 82 - 0.534 0.468 -0.322
ENSG00000139220 E026 0.1451727 0.043145052 1.000000000   12 81312160 81312168 9 - 0.087 0.000 -11.210
ENSG00000139220 E027 1.4277775 0.013114650 0.629386360 0.74474621 12 81325777 81325870 94 - 0.407 0.292 -0.695
ENSG00000139220 E028 0.5181333 0.020288961 0.882934969 0.92908336 12 81339180 81339187 8 - 0.159 0.170 0.112
ENSG00000139220 E029 0.6998377 0.016675729 0.392711298 0.53661933 12 81339188 81339209 22 - 0.159 0.292 1.112
ENSG00000139220 E030 1.0695787 0.012080994 0.347647980 0.49183911 12 81339210 81339334 125 - 0.367 0.170 -1.475
ENSG00000139220 E031 1.4822801 0.009901885 0.620999206 0.73804868 12 81341078 81341208 131 - 0.407 0.292 -0.696
ENSG00000139220 E032 0.9598804 0.031796497 0.471629987 0.61071809 12 81344664 81344693 30 - 0.324 0.170 -1.209
ENSG00000139220 E033 0.0000000       12 81344694 81344768 75 -      
ENSG00000139220 E034 1.6252627 0.033498952 0.497877810 0.63440517 12 81347533 81347663 131 - 0.443 0.292 -0.883
ENSG00000139220 E035 0.8105550 0.015182342 0.635043837 0.74941383 12 81347664 81347711 48 - 0.276 0.170 -0.888
ENSG00000139220 E036 0.8105550 0.015182342 0.635043837 0.74941383 12 81347712 81347770 59 - 0.276 0.170 -0.888
ENSG00000139220 E037 0.0000000       12 81350433 81350486 54 -      
ENSG00000139220 E038 1.1103636 0.011581706 0.954289559 0.97535172 12 81353119 81353339 221 - 0.324 0.291 -0.212
ENSG00000139220 E039 0.8837216 0.068781531 0.097306913 0.18636900 12 81358082 81358182 101 - 0.367 0.000 -13.794
ENSG00000139220 E040 0.9286724 0.015075944 0.472270685 0.61131106 12 81358183 81358217 35 - 0.324 0.170 -1.212
ENSG00000139220 E041 1.6952202 0.008911307 0.389246830 0.53336258 12 81362693 81362784 92 - 0.476 0.291 -1.060
ENSG00000139220 E042 1.0611596 0.014365813 0.351438154 0.49566641 12 81367108 81367170 63 - 0.367 0.170 -1.474
ENSG00000139220 E043 0.0000000       12 81368103 81368166 64 -      
ENSG00000139220 E044 1.9553766 0.007412574 0.052218201 0.11310461 12 81368725 81368856 132 - 0.563 0.170 -2.475
ENSG00000139220 E045 0.7469680 0.017232925 0.124988127 0.22710483 12 81369111 81369124 14 - 0.324 0.000 -13.532
ENSG00000139220 E046 1.3381542 0.010347608 0.023107858 0.05797222 12 81369125 81369194 70 - 0.476 0.000 -14.380
ENSG00000139220 E047 0.0000000       12 81369195 81369289 95 -      
ENSG00000139220 E048 0.0000000       12 81369290 81369293 4 -      
ENSG00000139220 E049 0.0000000       12 81369294 81369423 130 -      
ENSG00000139220 E050 1.4875932 0.009550862 0.015579187 0.04179963 12 81374634 81374748 115 - 0.507 0.000 -14.532
ENSG00000139220 E051 0.8921407 0.013696863 0.080662152 0.16058431 12 81374749 81374768 20 - 0.367 0.000 -13.795
ENSG00000139220 E052 0.0000000       12 81375733 81375795 63 -      
ENSG00000139220 E053 1.6672213 0.009991340 0.100791690 0.19166365 12 81375796 81375942 147 - 0.507 0.170 -2.212
ENSG00000139220 E054 1.3662668 0.009878544 0.187330786 0.31038355 12 81384023 81384244 222 - 0.443 0.170 -1.890
ENSG00000139220 E055 0.8751888 0.134829749 0.113078152 0.21002271 12 81405787 81405903 117 - 0.366 0.000 -13.790
ENSG00000139220 E056 0.0000000       12 81424849 81424957 109 -      
ENSG00000139220 E057 0.1515154 0.043482905 1.000000000   12 81439880 81439971 92 - 0.087 0.000 -11.211
ENSG00000139220 E058 0.8062886 0.024329411 0.635590551 0.74986283 12 81439972 81440046 75 - 0.275 0.170 -0.887
ENSG00000139220 E059 1.6242306 0.009057368 0.976228715 0.98913545 12 81445556 81445630 75 - 0.407 0.387 -0.111
ENSG00000139220 E060 2.1046994 0.007165686 0.924161800 0.95623362 12 81445631 81445720 90 - 0.476 0.464 -0.059
ENSG00000139220 E061 1.8789878 0.007872820 0.724380284 0.81791166 12 81457765 81457805 41 - 0.476 0.386 -0.475
ENSG00000139220 E062 1.6500539 0.228669258 0.929323634 0.95954641 12 81457806 81457866 61 - 0.442 0.381 -0.328
ENSG00000139220 E063 0.0000000       12 81505680 81506110 431 -      
ENSG00000139220 E064 0.0000000       12 81512284 81512384 101 -      
ENSG00000139220 E065 0.1515154 0.043482905 1.000000000   12 81535422 81535511 90 - 0.087 0.000 -11.211
ENSG00000139220 E066 0.0000000       12 81597952 81598371 420 -      
ENSG00000139220 E067 2.4064826 0.012328911 0.172702396 0.29172084 12 81675486 81675652 167 - 0.443 0.638 0.916
ENSG00000139220 E068 0.0000000       12 81676657 81676790 134 -      
ENSG00000139220 E069 2.9860380 0.005571398 0.005512687 0.01731944 12 81676791 81676844 54 - 0.407 0.796 1.762
ENSG00000139220 E070 0.0000000       12 81676845 81676847 3 -      
ENSG00000139220 E071 0.0000000       12 81687411 81687560 150 -      
ENSG00000139220 E072 7.5055518 0.040191001 0.023835986 0.05947209 12 81753973 81754223 251 - 0.801 1.075 1.032
ENSG00000139220 E073 4.2081777 0.008675311 0.105821269 0.19933502 12 81758400 81758507 108 - 0.636 0.828 0.784
ENSG00000139220 E074 1.0801878 0.015426429 0.350070017 0.49424827 12 81758508 81758693 186 - 0.367 0.170 -1.475
ENSG00000139220 E075 0.0000000       12 81759214 81759279 66 -      
ENSG00000139220 E076 1.5060391 0.037938361 0.498672134 0.63511402 12 81759280 81759553 274 - 0.367 0.463 0.517