ENSG00000139218

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369367 ENSG00000139218 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAF11 protein_coding protein_coding 24.75132 8.641123 40.02337 0.9533451 0.6499017 2.210244 7.7435327 2.5053753 13.6794659 0.1962304 0.36670966 2.44422057 0.30583333 0.2930667 0.34183333 0.04876667 3.838330e-01 2.991682e-44 FALSE TRUE
ENST00000395453 ENSG00000139218 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAF11 protein_coding protein_coding 24.75132 8.641123 40.02337 0.9533451 0.6499017 2.210244 1.7192099 1.3746331 2.7383584 0.2947509 0.09439467 0.98906635 0.07745833 0.1619667 0.06840000 -0.09356667 3.275109e-02 2.991682e-44   FALSE
ENST00000547950 ENSG00000139218 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAF11 protein_coding retained_intron 24.75132 8.641123 40.02337 0.9533451 0.6499017 2.210244 0.9031564 0.9602233 0.7834659 0.4889127 0.78346588 -0.29014866 0.06667500 0.1058333 0.01953333 -0.08630000 3.907679e-01 2.991682e-44 FALSE TRUE
ENST00000549162 ENSG00000139218 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAF11 protein_coding protein_coding 24.75132 8.641123 40.02337 0.9533451 0.6499017 2.210244 5.9272623 0.0000000 11.2083101 0.0000000 0.14250044 10.13163965 0.16413750 0.0000000 0.28030000 0.28030000 2.991682e-44 2.991682e-44 FALSE TRUE
ENST00000550629 ENSG00000139218 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAF11 protein_coding processed_transcript 24.75132 8.641123 40.02337 0.9533451 0.6499017 2.210244 1.6862707 1.7542379 1.8325058 0.2227531 0.65341524 0.06262407 0.09857917 0.2039000 0.04580000 -0.15810000 4.173201e-04 2.991682e-44 FALSE TRUE
ENST00000550893 ENSG00000139218 HEK293_OSMI2_2hA HEK293_TMG_2hB SCAF11 protein_coding protein_coding 24.75132 8.641123 40.02337 0.9533451 0.6499017 2.210244 2.3122216 1.4503931 2.6631700 0.3003924 0.70521094 0.87219486 0.12407917 0.1652000 0.06620000 -0.09900000 2.720349e-02 2.991682e-44 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139218 E001 64.9333489 0.0137565733 1.891328e-17 8.939782e-16 12 45919131 45919309 179 - 1.498 2.141 2.173
ENSG00000139218 E002 476.5987418 0.0094135345 2.473621e-07 2.328778e-06 12 45919310 45921408 2099 - 2.487 2.748 0.869
ENSG00000139218 E003 105.7289305 0.0003096611 7.750945e-01 8.550791e-01 12 45921409 45921864 456 - 1.880 1.918 0.128
ENSG00000139218 E004 81.0792534 0.0003442817 2.648192e-01 4.028134e-01 12 45921865 45922047 183 - 1.780 1.742 -0.127
ENSG00000139218 E005 80.0868281 0.0081535523 6.084576e-01 7.281819e-01 12 45922048 45922194 147 - 1.770 1.759 -0.036
ENSG00000139218 E006 10.8208901 0.0244997109 7.254643e-04 2.990557e-03 12 45922356 45922462 107 - 0.835 1.289 1.661
ENSG00000139218 E007 118.6426751 0.0003412377 1.355944e-09 1.960762e-08 12 45922463 45922582 120 - 1.884 2.150 0.893
ENSG00000139218 E008 87.2992088 0.0003020823 1.506125e-04 7.497262e-04 12 45922936 45922983 48 - 1.767 1.972 0.689
ENSG00000139218 E009 124.6801259 0.0035931501 8.511669e-05 4.522409e-04 12 45922984 45923154 171 - 1.919 2.132 0.716
ENSG00000139218 E010 112.0522006 0.0026315875 8.069327e-04 3.283435e-03 12 45924728 45924946 219 - 1.876 2.064 0.629
ENSG00000139218 E011 109.6764200 0.0002735400 4.018427e-02 9.137797e-02 12 45924947 45925074 128 - 1.882 1.998 0.389
ENSG00000139218 E012 135.6420228 0.0004871473 7.659276e-02 1.540401e-01 12 45926142 45926291 150 - 1.977 2.075 0.326
ENSG00000139218 E013 225.6202588 0.0001944252 6.649604e-01 7.726901e-01 12 45926292 45926715 424 - 2.212 2.223 0.036
ENSG00000139218 E014 756.1166325 0.0053470651 4.933865e-08 5.325656e-07 12 45926716 45928652 1937 - 2.760 2.598 -0.540
ENSG00000139218 E015 128.2935309 0.0110457108 9.535742e-04 3.800235e-03 12 45928653 45928783 131 - 1.996 1.793 -0.684
ENSG00000139218 E016 98.4973786 0.0022848410 1.281052e-06 1.039720e-05 12 45928784 45928859 76 - 1.891 1.614 -0.937
ENSG00000139218 E017 1.1050531 0.0115408913 1.000000e+00 1.000000e+00 12 45928860 45929965 1106 - 0.246 0.264 0.134
ENSG00000139218 E018 1.0308569 0.0172280356 3.255114e-01 4.689436e-01 12 45930950 45931505 556 - 0.276 0.000 -13.714
ENSG00000139218 E019 99.5869724 0.0020944750 2.714323e-05 1.631565e-04 12 45931506 45931612 107 - 1.891 1.664 -0.767
ENSG00000139218 E020 87.3003941 0.0040044018 7.096836e-04 2.933740e-03 12 45933131 45933232 102 - 1.832 1.632 -0.678
ENSG00000139218 E021 82.0839846 0.0071589460 3.823984e-04 1.706578e-03 12 45934176 45934285 110 - 1.811 1.568 -0.821
ENSG00000139218 E022 67.3531038 0.0003937434 8.043616e-06 5.458658e-05 12 45934447 45934505 59 - 1.731 1.443 -0.983
ENSG00000139218 E023 0.1515154 0.0421851931 9.061418e-01   12 45934506 45934510 5 - 0.052 0.000 -10.907
ENSG00000139218 E024 0.1451727 0.0426884670 9.035076e-01   12 45934976 45935083 108 - 0.052 0.000 -10.907
ENSG00000139218 E025 0.2987644 0.0293512082 1.000000e+00   12 45945084 45945248 165 - 0.098 0.000 -11.907
ENSG00000139218 E026 71.0158900 0.0003547659 4.182840e-10 6.644529e-09 12 45945249 45945310 62 - 1.764 1.323 -1.511
ENSG00000139218 E027 45.1197698 0.0009598262 1.928766e-07 1.853970e-06 12 45945311 45945313 3 - 1.573 1.103 -1.640
ENSG00000139218 E028 81.0443193 0.0003095626 8.823052e-09 1.098587e-07 12 45948437 45948529 93 - 1.814 1.456 -1.221
ENSG00000139218 E029 47.0009937 0.0004519619 3.955425e-06 2.880761e-05 12 45948530 45948537 8 - 1.585 1.205 -1.317
ENSG00000139218 E030 68.9271733 0.0005717189 4.481193e-06 3.225734e-05 12 45951650 45951727 78 - 1.740 1.443 -1.013
ENSG00000139218 E031 0.4386386 0.1579732745 3.740920e-01 5.185149e-01 12 45951728 45951752 25 - 0.098 0.262 1.707
ENSG00000139218 E032 2.3596736 0.1433719259 4.358243e-01 5.779841e-01 12 45953828 45953857 30 - 0.463 0.262 -1.199
ENSG00000139218 E033 8.4161668 0.0028841300 4.022556e-02 9.144660e-02 12 45954734 45956192 1459 - 0.888 0.545 -1.426
ENSG00000139218 E034 1.3381542 0.0095575484 2.109202e-01 3.396255e-01 12 45960162 45960214 53 - 0.331 0.000 -14.077
ENSG00000139218 E035 29.4097100 0.0359159040 5.231055e-12 1.139899e-10 12 45960455 45960984 530 - 1.085 1.894 2.793
ENSG00000139218 E036 46.2272915 0.0163812524 1.470913e-05 9.404340e-05 12 45960985 45961322 338 - 1.449 1.844 1.342
ENSG00000139218 E037 2.5808913 0.0064742567 7.990654e-01 8.718119e-01 12 45961407 45961695 289 - 0.463 0.426 -0.189
ENSG00000139218 E038 1.3232786 0.0324630639 2.189867e-01 3.491648e-01 12 45961696 45961699 4 - 0.331 0.000 -14.076
ENSG00000139218 E039 117.8209334 0.0012849070 2.357513e-01 3.692693e-01 12 45961700 45961857 158 - 1.942 1.909 -0.111
ENSG00000139218 E040 83.7101380 0.0003615293 3.300518e-02 7.781579e-02 12 45964107 45964188 82 - 1.804 1.708 -0.324
ENSG00000139218 E041 18.1886817 0.0009774398 5.789497e-02 1.230248e-01 12 45974190 45975734 1545 - 1.179 0.971 -0.755
ENSG00000139218 E042 0.5806908 0.8077286474 1.000000e+00 1.000000e+00 12 45987422 45987467 46 - 0.177 0.000 -12.894
ENSG00000139218 E043 80.4641309 0.0008568432 2.136779e-02 5.436415e-02 12 45990353 45990811 459 - 1.790 1.679 -0.377
ENSG00000139218 E044 6.5237961 0.0084350865 6.736164e-01 7.792545e-01 12 45991885 45992218 334 - 0.765 0.714 -0.208