ENSG00000139197

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000266563 ENSG00000139197 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX5 protein_coding protein_coding 29.29839 39.5109 23.16362 0.6383009 0.3654773 -0.7701328 12.604398 21.0934397 10.7460724 0.7669040 1.5533240 -0.9723268 0.42552500 0.53350000 0.46493333 -0.06856667 7.066555e-01 3.076956e-08 FALSE  
ENST00000420616 ENSG00000139197 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX5 protein_coding protein_coding 29.29839 39.5109 23.16362 0.6383009 0.3654773 -0.7701328 2.884696 3.7808206 2.1767857 0.7394040 0.3205511 -0.7936983 0.09986250 0.09516667 0.09356667 -0.00160000 1.000000e+00 3.076956e-08 FALSE  
ENST00000434354 ENSG00000139197 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX5 protein_coding protein_coding 29.29839 39.5109 23.16362 0.6383009 0.3654773 -0.7701328 1.655788 3.1514820 0.4473756 0.3445090 0.4473756 -2.7891497 0.05699167 0.07960000 0.01880000 -0.06080000 1.218242e-01 3.076956e-08 FALSE  
ENST00000536841 ENSG00000139197 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX5 protein_coding protein_coding 29.29839 39.5109 23.16362 0.6383009 0.3654773 -0.7701328 1.475516 1.0390213 2.2776333 0.1151428 0.2495507 1.1248118 0.05507500 0.02633333 0.09810000 0.07176667 3.076956e-08 3.076956e-08 FALSE  
ENST00000675855 ENSG00000139197 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX5 protein_coding protein_coding 29.29839 39.5109 23.16362 0.6383009 0.3654773 -0.7701328 2.918597 0.7112478 1.9184533 0.7112478 0.9755388 1.4188774 0.09390833 0.01860000 0.08386667 0.06526667 4.718037e-01 3.076956e-08 FALSE  
MSTRG.6737.12 ENSG00000139197 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX5 protein_coding   29.29839 39.5109 23.16362 0.6383009 0.3654773 -0.7701328 1.367383 2.9761025 0.5207755 0.8777029 0.3031440 -2.4920900 0.04677917 0.07563333 0.02270000 -0.05293333 4.125201e-01 3.076956e-08 FALSE  
MSTRG.6737.14 ENSG00000139197 HEK293_OSMI2_2hA HEK293_TMG_2hB PEX5 protein_coding   29.29839 39.5109 23.16362 0.6383009 0.3654773 -0.7701328 3.508888 4.5172136 1.4648823 0.6527491 0.7391545 -1.6180235 0.11482917 0.11410000 0.06243333 -0.05166667 6.875271e-01 3.076956e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139197 E001 0.0000000       12 7188685 7188723 39 +      
ENSG00000139197 E002 0.5117019 0.0245753597 2.539617e-01 3.905837e-01 12 7188724 7188810 87 + 0.000 0.235 18.068
ENSG00000139197 E003 0.2214452 0.0391983630 1.000000e+00   12 7189163 7189212 50 + 0.000 0.093 18.020
ENSG00000139197 E004 0.2214452 0.0391983630 1.000000e+00   12 7189213 7189531 319 + 0.000 0.093 18.020
ENSG00000139197 E005 0.0000000       12 7189584 7189610 27 +      
ENSG00000139197 E006 0.0000000       12 7189611 7189660 50 +      
ENSG00000139197 E007 0.0000000       12 7189661 7189684 24 +      
ENSG00000139197 E008 0.0000000       12 7189685 7189685 1 +      
ENSG00000139197 E009 0.0000000       12 7189686 7189686 1 +      
ENSG00000139197 E010 0.1515154 0.0429165571 2.474651e-01   12 7189687 7189690 4 + 0.159 0.000 -20.043
ENSG00000139197 E011 0.4481018 0.1283876071 1.000000e+00 1.000000e+00 12 7189691 7189692 2 + 0.159 0.168 0.094
ENSG00000139197 E012 0.6298062 0.0186546414 7.273551e-01 8.201024e-01 12 7189693 7189694 2 + 0.159 0.235 0.697
ENSG00000139197 E013 0.6298062 0.0186546414 7.273551e-01 8.201024e-01 12 7189695 7189696 2 + 0.159 0.235 0.697
ENSG00000139197 E014 4.5275621 0.0036245944 9.993645e-01 1.000000e+00 12 7189697 7189706 10 + 0.697 0.725 0.115
ENSG00000139197 E015 11.3361262 0.0015507149 9.298547e-01 9.598437e-01 12 7189707 7189714 8 + 1.030 1.071 0.148
ENSG00000139197 E016 39.7215794 0.0005662180 2.608748e-02 6.412355e-02 12 7189715 7189750 36 + 1.634 1.538 -0.324
ENSG00000139197 E017 1.2115291 0.0110296606 1.749040e-02 4.602280e-02 12 7189751 7189844 94 + 0.563 0.170 -2.470
ENSG00000139197 E018 1.0663564 0.0117513010 4.229911e-02 9.527219e-02 12 7189845 7189848 4 + 0.507 0.170 -2.207
ENSG00000139197 E019 3.9752787 0.0040814810 1.384981e-02 3.788723e-02 12 7189849 7189903 55 + 0.857 0.531 -1.369
ENSG00000139197 E020 15.0029242 0.0250353732 5.839019e-01 7.079268e-01 12 7189904 7189955 52 + 1.181 1.152 -0.104
ENSG00000139197 E021 17.4386507 0.0257848788 4.857392e-01 6.235640e-01 12 7189956 7189980 25 + 1.251 1.209 -0.148
ENSG00000139197 E022 21.5380711 0.0072656215 3.905796e-01 5.345470e-01 12 7189981 7190021 41 + 1.338 1.297 -0.145
ENSG00000139197 E023 36.2184602 0.0006896871 3.742218e-01 5.186379e-01 12 7190022 7190088 67 + 1.545 1.523 -0.073
ENSG00000139197 E024 41.2532492 0.0005565891 4.099780e-01 5.535930e-01 12 7190089 7190152 64 + 1.528 1.610 0.282
ENSG00000139197 E025 47.0370207 0.0005032953 3.662732e-01 5.105988e-01 12 7190153 7190216 64 + 1.655 1.640 -0.052
ENSG00000139197 E026 16.3609367 0.0011209081 2.276041e-07 2.158752e-06 12 7190217 7190360 144 + 1.440 1.044 -1.399
ENSG00000139197 E027 9.1718387 0.0025403356 5.495600e-03 1.727521e-02 12 7190361 7190361 1 + 1.141 0.873 -0.988
ENSG00000139197 E028 149.5862199 0.0051870547 2.390152e-03 8.430435e-03 12 7190362 7190484 123 + 2.208 2.106 -0.343
ENSG00000139197 E029 108.4053477 0.0130533182 4.690189e-02 1.036505e-01 12 7190485 7190524 40 + 2.065 1.971 -0.312
ENSG00000139197 E030 8.5960662 0.0050940162 5.245583e-02 1.135323e-01 12 7190525 7190569 45 + 1.065 0.874 -0.712
ENSG00000139197 E031 3.5349346 0.0704971287 1.801386e-05 1.128977e-04 12 7190570 7190793 224 + 0.994 0.235 -3.623
ENSG00000139197 E032 2.6041859 0.0264143160 1.007074e-05 6.686073e-05 12 7190812 7190887 76 + 0.883 0.170 -3.792
ENSG00000139197 E033 96.8653277 0.0122106113 1.023593e-03 4.040097e-03 12 7190888 7190923 36 + 2.064 1.891 -0.581
ENSG00000139197 E034 186.3231339 0.0048213990 5.078559e-03 1.614535e-02 12 7191226 7191358 133 + 2.292 2.208 -0.279
ENSG00000139197 E035 76.1028813 0.0003775353 1.145147e-01 2.121379e-01 12 7191569 7191571 3 + 1.874 1.841 -0.113
ENSG00000139197 E036 194.4689405 0.0028318041 2.823384e-02 6.847623e-02 12 7191572 7191700 129 + 2.286 2.241 -0.151
ENSG00000139197 E037 193.6823620 0.0048753864 1.530904e-01 2.658805e-01 12 7199011 7199113 103 + 2.273 2.247 -0.087
ENSG00000139197 E038 2.5777893 0.0432918547 7.126097e-01 8.092920e-01 12 7201735 7201750 16 + 0.442 0.535 0.457
ENSG00000139197 E039 191.7270056 0.0032163533 1.699517e-01 2.881434e-01 12 7201751 7201841 91 + 2.262 2.244 -0.059
ENSG00000139197 E040 2.1733815 0.0905141641 7.590963e-01 8.435350e-01 12 7201842 7202226 385 + 0.506 0.465 -0.206
ENSG00000139197 E041 31.5646811 0.0034273362 6.642932e-01 7.721279e-01 12 7202241 7202261 21 + 1.480 1.483 0.012
ENSG00000139197 E042 53.8953208 0.0015676448 8.225453e-01 8.881155e-01 12 7202262 7202351 90 + 1.692 1.714 0.075
ENSG00000139197 E043 222.8432525 0.0002188012 4.216021e-03 1.374720e-02 12 7202612 7202704 93 + 2.340 2.302 -0.126
ENSG00000139197 E044 147.0907781 0.0004072663 4.461616e-03 1.443374e-02 12 7203432 7203455 24 + 2.174 2.119 -0.183
ENSG00000139197 E045 215.9712218 0.0011599022 1.529308e-02 4.115224e-02 12 7203456 7203551 96 + 2.328 2.292 -0.120
ENSG00000139197 E046 227.3000405 0.0003223591 1.821884e-01 3.039393e-01 12 7207659 7207802 144 + 2.324 2.325 0.001
ENSG00000139197 E047 177.9734175 0.0002350872 8.111360e-01 8.801861e-01 12 7208010 7208080 71 + 2.190 2.231 0.138
ENSG00000139197 E048 303.0300217 0.0002791130 1.590607e-01 2.738667e-01 12 7208457 7208669 213 + 2.444 2.448 0.010
ENSG00000139197 E049 290.7418611 0.0014988086 6.671452e-01 7.744640e-01 12 7209005 7209170 166 + 2.411 2.434 0.077
ENSG00000139197 E050 273.7587545 0.0016521599 6.024747e-01 7.234435e-01 12 7209683 7209840 158 + 2.366 2.417 0.169
ENSG00000139197 E051 216.5276371 0.0010705745 9.388253e-02 1.811989e-01 12 7210022 7210129 108 + 2.239 2.324 0.284
ENSG00000139197 E052 215.6537400 0.0002075291 2.895178e-02 6.991228e-02 12 7210130 7210242 113 + 2.234 2.326 0.309
ENSG00000139197 E053 1234.4794097 0.0058764628 1.192177e-08 1.449177e-07 12 7210243 7211483 1241 + 2.897 3.114 0.722
ENSG00000139197 E054 2.3928798 0.0060245576 3.767379e-02 8.672052e-02 12 7212772 7212871 100 + 0.697 0.387 -1.470
ENSG00000139197 E055 0.5879639 0.0218732321 9.304666e-02 1.798881e-01 12 7218402 7218574 173 + 0.367 0.093 -2.471