ENSG00000139174

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345127 ENSG00000139174 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE1 protein_coding protein_coding 2.173138 2.181964 2.332283 0.1704239 0.2995845 0.09569075 0.35800461 0.47529274 0.2106601 0.01070133 0.004427417 -1.1370295 0.17247500 0.22120000 0.09446667 -0.12673333 0.03530081 0.03530081 FALSE TRUE
ENST00000445766 ENSG00000139174 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE1 protein_coding protein_coding 2.173138 2.181964 2.332283 0.1704239 0.2995845 0.09569075 0.33241708 0.17105893 0.0000000 0.17105893 0.000000000 -4.1783875 0.15548333 0.07306667 0.00000000 -0.07306667 0.73487910 0.03530081 FALSE TRUE
ENST00000455697 ENSG00000139174 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE1 protein_coding protein_coding 2.173138 2.181964 2.332283 0.1704239 0.2995845 0.09569075 0.04398087 0.08229065 0.2306271 0.08229065 0.167278783 1.3825428 0.01785000 0.03483333 0.08746667 0.05263333 0.72638835 0.03530081 FALSE TRUE
ENST00000552200 ENSG00000139174 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE1 protein_coding processed_transcript 2.173138 2.181964 2.332283 0.1704239 0.2995845 0.09569075 0.06669279 0.00000000 0.1425500 0.00000000 0.142550011 3.9312104 0.02313750 0.00000000 0.05403333 0.05403333 0.79877983 0.03530081 FALSE FALSE
ENST00000552240 ENSG00000139174 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE1 protein_coding protein_coding 2.173138 2.181964 2.332283 0.1704239 0.2995845 0.09569075 0.12496493 0.00000000 0.1880776 0.00000000 0.188077604 4.3079939 0.05717500 0.00000000 0.07166667 0.07166667 0.81244550 0.03530081 FALSE TRUE
ENST00000639958 ENSG00000139174 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE1 protein_coding protein_coding 2.173138 2.181964 2.332283 0.1704239 0.2995845 0.09569075 0.19288142 0.10273030 0.2838829 0.10273030 0.283882903 1.3823661 0.09985417 0.04346667 0.16380000 0.12033333 1.00000000 0.03530081 FALSE TRUE
ENST00000640646 ENSG00000139174 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE1 protein_coding protein_coding 2.173138 2.181964 2.332283 0.1704239 0.2995845 0.09569075 0.36496454 0.42985624 0.6863259 0.11940237 0.157190526 0.6627306 0.15780000 0.19853333 0.28810000 0.08956667 0.53299420 0.03530081 FALSE FALSE
ENST00000640840 ENSG00000139174 HEK293_OSMI2_2hA HEK293_TMG_2hB PRICKLE1 protein_coding retained_intron 2.173138 2.181964 2.332283 0.1704239 0.2995845 0.09569075 0.42778102 0.76939656 0.4649990 0.03048696 0.235536978 -0.7144331 0.19608750 0.35686667 0.17666667 -0.18020000 0.51112982 0.03530081 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139174 E001 0.5117019 0.0223042534 0.136322307 0.242927375 12 42456757 42456762 6 - 0.000 0.266 10.278
ENSG00000139174 E002 13.7707439 0.0013516877 0.006198649 0.019138126 12 42456763 42458359 1597 - 0.984 1.239 0.921
ENSG00000139174 E003 0.5149111 0.0207377122 0.737919172 0.827958029 12 42458360 42458371 12 - 0.138 0.194 0.587
ENSG00000139174 E004 1.7336236 0.0130730132 0.088360334 0.172617687 12 42458372 42458396 25 - 0.243 0.547 1.750
ENSG00000139174 E005 18.5965791 0.0371384318 0.015976863 0.042678634 12 42458397 42458824 428 - 1.088 1.378 1.023
ENSG00000139174 E006 6.7707357 0.0029293821 0.005064836 0.016107132 12 42458825 42458828 4 - 0.642 1.000 1.414
ENSG00000139174 E007 10.8575829 0.0017085186 0.002006720 0.007247076 12 42458829 42458950 122 - 0.846 1.170 1.200
ENSG00000139174 E008 22.4047475 0.0010112702 0.001755705 0.006458129 12 42458951 42459264 314 - 1.205 1.435 0.803
ENSG00000139174 E009 9.9561574 0.0018168716 0.024175910 0.060170441 12 42459265 42459279 15 - 0.868 1.109 0.891
ENSG00000139174 E010 77.1032387 0.0006270429 0.020503111 0.052552211 12 42459280 42460665 1386 - 1.832 1.913 0.275
ENSG00000139174 E011 0.1482932 0.0413733506 0.620549306   12 42463622 42463717 96 - 0.000 0.108 11.015
ENSG00000139174 E012 38.4526790 0.0006332188 0.008860971 0.025935240 12 42464395 42465136 742 - 1.670 1.531 -0.475
ENSG00000139174 E013 11.1302355 0.0072931865 0.024076506 0.059969522 12 42465137 42465258 122 - 1.205 0.975 -0.833
ENSG00000139174 E014 10.2629627 0.0018082572 0.012455813 0.034631432 12 42466194 42466380 187 - 1.184 0.935 -0.908
ENSG00000139174 E015 0.0000000       12 42466381 42466391 11 -      
ENSG00000139174 E016 7.8503368 0.0024105632 0.035025209 0.081697889 12 42468626 42468722 97 - 1.061 0.822 -0.898
ENSG00000139174 E017 8.0687738 0.0647932595 0.217459406 0.347334790 12 42468723 42468829 107 - 1.047 0.850 -0.738
ENSG00000139174 E018 4.4923784 0.0832992768 0.614259932 0.732793968 12 42469450 42469476 27 - 0.770 0.679 -0.374
ENSG00000139174 E019 5.4671357 0.0510150808 0.119462079 0.219180797 12 42469477 42469504 28 - 0.930 0.673 -1.017
ENSG00000139174 E020 8.9882353 0.0618593514 0.085717825 0.168543367 12 42469505 42469587 83 - 1.127 0.861 -0.985
ENSG00000139174 E021 0.0000000       12 42469588 42469660 73 -      
ENSG00000139174 E022 0.0000000       12 42469838 42470029 192 -      
ENSG00000139174 E023 9.9856159 0.0159463860 0.081795796 0.162377066 12 42470246 42470359 114 - 1.139 0.936 -0.744
ENSG00000139174 E024 10.8653198 0.0066786982 0.057575507 0.122459994 12 42472385 42472561 177 - 1.173 0.976 -0.715
ENSG00000139174 E025 3.0925046 0.0287946252 0.066319628 0.137250572 12 42472562 42472564 3 - 0.770 0.472 -1.311
ENSG00000139174 E026 0.4031496 0.0263087099 0.283294435 0.423376175 12 42482785 42483091 307 - 0.000 0.195 11.994
ENSG00000139174 E027 0.1515154 0.0441941302 0.379504797   12 42483376 42483672 297 - 0.139 0.000 -12.391
ENSG00000139174 E028 1.6417472 0.1653297798 0.427916072 0.570740544 12 42483758 42483812 55 - 0.511 0.331 -0.972
ENSG00000139174 E029 1.6825347 0.0355335312 0.012905671 0.035693086 12 42483813 42483985 173 - 0.641 0.194 -2.581
ENSG00000139174 E030 0.0000000       12 42483986 42483995 10 -      
ENSG00000139174 E031 0.1472490 0.0436551428 0.379876206   12 42484054 42484273 220 - 0.138 0.000 -12.392
ENSG00000139174 E032 0.4396707 0.0266854351 0.050537788 0.110114463 12 42484274 42484444 171 - 0.328 0.000 -13.899
ENSG00000139174 E033 0.6256415 0.0176263919 0.200272132 0.326556394 12 42524755 42525046 292 - 0.328 0.108 -1.998
ENSG00000139174 E034 4.8596254 0.0037677194 0.972299012 0.986721150 12 42550208 42550329 122 - 0.770 0.763 -0.028
ENSG00000139174 E035 0.0000000       12 42584359 42584480 122 -      
ENSG00000139174 E036 0.0000000       12 42589162 42589464 303 -      
ENSG00000139174 E037 10.0924794 0.0038347580 0.556293458 0.684967847 12 42589465 42589597 133 - 1.075 1.013 -0.228
ENSG00000139174 E038 5.6638639 0.0030389172 0.512542636 0.647447638 12 42589598 42589746 149 - 0.868 0.783 -0.332
ENSG00000139174 E039 0.0000000       12 42590274 42590355 82 -