ENSG00000139163

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000266517 ENSG00000139163 HEK293_OSMI2_2hA HEK293_TMG_2hB ETNK1 protein_coding protein_coding 16.72251 4.984749 25.41006 0.4332084 0.0715432 2.347484 10.2707600 2.34305425 15.93427511 0.51680216 0.18477833 2.7604320 0.55459167 0.46023333 0.627100000 0.16686667 0.165086966 0.008836366 FALSE TRUE
ENST00000539974 ENSG00000139163 HEK293_OSMI2_2hA HEK293_TMG_2hB ETNK1 protein_coding retained_intron 16.72251 4.984749 25.41006 0.4332084 0.0715432 2.347484 3.1112152 0.60724538 4.42898436 0.60724538 1.06834258 2.8463136 0.13110000 0.11420000 0.174300000 0.06010000 0.306955380 0.008836366 FALSE FALSE
ENST00000544191 ENSG00000139163 HEK293_OSMI2_2hA HEK293_TMG_2hB ETNK1 protein_coding retained_intron 16.72251 4.984749 25.41006 0.4332084 0.0715432 2.347484 1.0548813 0.07882275 2.02354167 0.07882275 0.58353596 4.5169215 0.06829583 0.01430000 0.079600000 0.06530000 0.154937542 0.008836366   FALSE
ENST00000545979 ENSG00000139163 HEK293_OSMI2_2hA HEK293_TMG_2hB ETNK1 protein_coding protein_coding 16.72251 4.984749 25.41006 0.4332084 0.0715432 2.347484 0.1603661 0.30637833 0.06710337 0.06664724 0.06710337 -2.0367849 0.03084583 0.06493333 0.002633333 -0.06230000 0.008836366 0.008836366   FALSE
ENST00000672951 ENSG00000139163 HEK293_OSMI2_2hA HEK293_TMG_2hB ETNK1 protein_coding protein_coding 16.72251 4.984749 25.41006 0.4332084 0.0715432 2.347484 1.2942214 1.16419730 1.81397191 0.33494909 0.34128164 0.6354087 0.14487500 0.24830000 0.071300000 -0.17700000 0.089306351 0.008836366 FALSE TRUE
ENST00000673406 ENSG00000139163 HEK293_OSMI2_2hA HEK293_TMG_2hB ETNK1 protein_coding nonsense_mediated_decay 16.72251 4.984749 25.41006 0.4332084 0.0715432 2.347484 0.1066099 0.33782124 0.10042596 0.17708017 0.10042596 -1.6552667 0.02205833 0.06970000 0.003933333 -0.06576667 0.250969673 0.008836366 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139163 E001 0.0000000       12 22625075 22625140 66 +      
ENSG00000139163 E002 0.0000000       12 22625141 22625141 1 +      
ENSG00000139163 E003 2.3670485 0.0064137786 2.960198e-02 7.117483e-02 12 22625142 22625170 29 + 0.528 0.000 -22.370
ENSG00000139163 E004 9.4541681 0.0032166741 5.973353e-01 7.191186e-01 12 22625171 22625191 21 + 0.947 0.871 -0.288
ENSG00000139163 E005 68.9882581 0.0300696108 2.942230e-01 4.353200e-01 12 22625192 22625356 165 + 1.734 1.808 0.249
ENSG00000139163 E006 49.0356753 0.0221508109 7.706502e-01 8.519125e-01 12 22625357 22625381 25 + 1.605 1.611 0.023
ENSG00000139163 E007 115.0546328 0.0050985077 7.673089e-01 8.495723e-01 12 22625382 22625550 169 + 1.970 1.972 0.006
ENSG00000139163 E008 66.7315197 0.0003638365 7.021235e-01 8.010013e-01 12 22625551 22625586 36 + 1.743 1.720 -0.080
ENSG00000139163 E009 2.6142338 0.0241718042 3.076489e-07 2.839618e-06 12 22625814 22626200 387 + 0.160 0.982 4.271
ENSG00000139163 E010 0.3289534 0.0379357491 2.453769e-01   12 22640432 22643762 3331 + 0.060 0.234 2.271
ENSG00000139163 E011 116.7929312 0.0002636526 3.500145e-01 4.941920e-01 12 22643763 22643888 126 + 1.987 1.945 -0.140
ENSG00000139163 E012 99.1154764 0.0003447343 1.580951e-01 2.725820e-01 12 22643889 22644022 134 + 1.894 1.952 0.196
ENSG00000139163 E013 8.3170598 0.0021605620 4.095407e-11 7.705457e-10 12 22644211 22644587 377 + 0.614 1.351 2.783
ENSG00000139163 E014 0.0000000       12 22646019 22646055 37 +      
ENSG00000139163 E015 7.8563994 0.0021884423 2.192305e-10 3.643846e-09 12 22656432 22656745 314 + 0.598 1.322 2.755
ENSG00000139163 E016 1.0351207 0.0130803079 6.689975e-02 1.382216e-01 12 22656746 22657197 452 + 0.160 0.498 2.271
ENSG00000139163 E017 90.3972545 0.0130587643 1.709006e-01 2.893500e-01 12 22659014 22659154 141 + 1.885 1.772 -0.381
ENSG00000139163 E018 0.2987644 0.0276603456 1.000000e+00   12 22659155 22660027 873 + 0.113 0.000 -19.369
ENSG00000139163 E019 96.5638412 0.0198858171 3.697082e-01 5.141075e-01 12 22661063 22661205 143 + 1.909 1.819 -0.303
ENSG00000139163 E020 0.8084787 0.1121593535 8.335221e-01 8.957097e-01 12 22661206 22661228 23 + 0.202 0.236 0.283
ENSG00000139163 E021 3.1891562 0.0156357438 3.432098e-01 4.872707e-01 12 22668598 22668700 103 + 0.582 0.386 -0.978
ENSG00000139163 E022 5.5215458 0.0029558908 5.514089e-01 6.808807e-01 12 22671086 22671271 186 + 0.759 0.660 -0.409
ENSG00000139163 E023 70.5881950 0.0146644427 7.403008e-01 8.297555e-01 12 22671272 22671355 84 + 1.767 1.722 -0.153
ENSG00000139163 E024 105.1396743 0.0004409063 5.711689e-01 6.975171e-01 12 22673500 22673660 161 + 1.937 1.909 -0.096
ENSG00000139163 E025 0.0000000       12 22682281 22682339 59 +      
ENSG00000139163 E026 81.7104946 0.0003184552 1.567883e-01 2.708183e-01 12 22684483 22684556 74 + 1.839 1.765 -0.251
ENSG00000139163 E027 1295.5224785 0.0180109592 5.671775e-01 6.940315e-01 12 22684882 22690665 5784 + 3.021 3.000 -0.071