ENSG00000139154

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000266508 ENSG00000139154 HEK293_OSMI2_2hA HEK293_TMG_2hB AEBP2 protein_coding protein_coding 10.99035 3.697938 18.3811 0.2674084 1.717458 2.310319 2.6082847 1.6985881 3.6563678 0.23902794 0.376894415 1.101547 0.29607917 0.46326667 0.19866667 -0.26460000 2.764534e-03 1.909139e-10 FALSE TRUE
ENST00000360995 ENSG00000139154 HEK293_OSMI2_2hA HEK293_TMG_2hB AEBP2 protein_coding protein_coding 10.99035 3.697938 18.3811 0.2674084 1.717458 2.310319 0.4056481 0.9568558 0.3279632 0.22757493 0.005672651 -1.516434 0.07449583 0.25676667 0.01826667 -0.23850000 1.909139e-10 1.909139e-10 FALSE TRUE
ENST00000398864 ENSG00000139154 HEK293_OSMI2_2hA HEK293_TMG_2hB AEBP2 protein_coding protein_coding 10.99035 3.697938 18.3811 0.2674084 1.717458 2.310319 1.4542523 0.1745788 2.6467056 0.17457883 0.215401292 3.847329 0.13172500 0.04940000 0.14656667 0.09716667 2.165046e-01 1.909139e-10 FALSE TRUE
ENST00000541908 ENSG00000139154 HEK293_OSMI2_2hA HEK293_TMG_2hB AEBP2 protein_coding protein_coding 10.99035 3.697938 18.3811 0.2674084 1.717458 2.310319 4.7445271 0.5607343 9.0737812 0.28326487 0.895143740 3.992402 0.34047917 0.14680000 0.49316667 0.34636667 2.260284e-01 1.909139e-10 FALSE TRUE
ENST00000673644 ENSG00000139154 HEK293_OSMI2_2hA HEK293_TMG_2hB AEBP2 protein_coding protein_coding 10.99035 3.697938 18.3811 0.2674084 1.717458 2.310319 0.7686634 0.0000000 1.0472975 0.00000000 0.605246251 6.724238 0.06112083 0.00000000 0.05170000 0.05170000 4.040909e-01 1.909139e-10 FALSE TRUE
MSTRG.6922.3 ENSG00000139154 HEK293_OSMI2_2hA HEK293_TMG_2hB AEBP2 protein_coding   10.99035 3.697938 18.3811 0.2674084 1.717458 2.310319 0.8449594 0.3071813 1.6289860 0.02290043 0.150125679 2.369424 0.07569167 0.08376667 0.09166667 0.00790000 9.618930e-01 1.909139e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139154 E001 0.0000000       12 19404045 19404065 21 +      
ENSG00000139154 E002 0.1817044 0.0456085050 1.377626e-01   12 19404066 19404124 59 + 0.000 0.205 11.119
ENSG00000139154 E003 0.0000000       12 19404125 19404216 92 +      
ENSG00000139154 E004 1.8865902 0.1065827133 6.826262e-01 7.860430e-01 12 19439458 19439491 34 + 0.440 0.346 -0.527
ENSG00000139154 E005 10.5467883 0.0954301866 5.778561e-01 7.030350e-01 12 19439492 19439673 182 + 1.041 0.916 -0.465
ENSG00000139154 E006 71.5977320 0.0083296818 1.053252e-01 1.985862e-01 12 19439674 19440323 650 + 1.824 1.740 -0.283
ENSG00000139154 E007 46.5688187 0.0055631950 2.269056e-01 3.586908e-01 12 19440324 19440370 47 + 1.634 1.572 -0.213
ENSG00000139154 E008 4.0933658 0.0358539244 5.906082e-04 2.499251e-03 12 19440581 19440727 147 + 0.411 0.981 2.440
ENSG00000139154 E009 42.0985486 0.0028394729 6.249306e-02 1.308349e-01 12 19462510 19462525 16 + 1.601 1.495 -0.365
ENSG00000139154 E010 104.8844697 0.0003007037 7.628478e-02 1.535593e-01 12 19462526 19462717 192 + 1.980 1.932 -0.162
ENSG00000139154 E011 90.9833413 0.0002960577 1.042544e-02 2.980649e-02 12 19473248 19473355 108 + 1.929 1.840 -0.298
ENSG00000139154 E012 131.8219188 0.0005594103 3.708373e-07 3.366590e-06 12 19493800 19493986 187 + 2.105 1.935 -0.570
ENSG00000139154 E013 0.4502799 0.0295336483 4.856130e-01 6.234781e-01 12 19500093 19500096 4 + 0.184 0.000 -13.522
ENSG00000139154 E014 82.3246042 0.0066992978 3.685904e-05 2.142565e-04 12 19500097 19500128 32 + 1.915 1.681 -0.789
ENSG00000139154 E015 100.8625472 0.0020236547 3.087153e-04 1.415056e-03 12 19500129 19500221 93 + 1.986 1.840 -0.492
ENSG00000139154 E016 83.3545564 0.0003351444 8.250954e-03 2.441953e-02 12 19512398 19512465 68 + 1.894 1.796 -0.329
ENSG00000139154 E017 93.1122058 0.0032932209 3.017623e-02 7.231324e-02 12 19514671 19514784 114 + 1.940 1.851 -0.300
ENSG00000139154 E018 0.6060617 0.7970533328 7.714320e-01 8.524534e-01 12 19515421 19515434 14 + 0.233 0.000 -12.543
ENSG00000139154 E019 61.6540240 0.0083983330 6.054491e-02 1.275499e-01 12 19518087 19518113 27 + 1.769 1.653 -0.391
ENSG00000139154 E020 112.2127135 0.0009571714 4.129851e-01 5.565310e-01 12 19518114 19518674 561 + 1.983 2.035 0.176
ENSG00000139154 E021 417.0719930 0.0015015577 2.222721e-31 4.084267e-29 12 19518675 19522239 3565 + 2.481 2.740 0.860
ENSG00000139154 E022 4.1778735 0.0156708396 1.727556e-02 4.555683e-02 12 19552853 19553272 420 + 0.539 0.916 1.558
ENSG00000139154 E023 0.0000000       12 19720633 19720801 169 +