ENSG00000139117

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331366 ENSG00000139117 HEK293_OSMI2_2hA HEK293_TMG_2hB CPNE8 protein_coding protein_coding 4.259302 1.245685 7.632287 0.2303179 0.6151628 2.605529 3.0303835 1.223073 4.9769131 0.2090975 0.28332444 2.015889 0.7888708 0.9865333 0.6563333 -0.3302000 5.170528e-07 7.056361e-08 FALSE TRUE
ENST00000360449 ENSG00000139117 HEK293_OSMI2_2hA HEK293_TMG_2hB CPNE8 protein_coding protein_coding 4.259302 1.245685 7.632287 0.2303179 0.6151628 2.605529 0.8232371 0.000000 1.6347397 0.0000000 0.04696673 7.361715 0.1077167 0.0000000 0.2172333 0.2172333 7.056361e-08 7.056361e-08 FALSE TRUE
ENST00000550863 ENSG00000139117 HEK293_OSMI2_2hA HEK293_TMG_2hB CPNE8 protein_coding protein_coding 4.259302 1.245685 7.632287 0.2303179 0.6151628 2.605529 0.1198724 0.000000 0.5370818 0.0000000 0.15265575 5.773685 0.0199375 0.0000000 0.0682000 0.0682000 8.345202e-03 7.056361e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139117 E001 0.0000000       12 38646822 38647093 272 -      
ENSG00000139117 E002 1.6980474 0.2886347825 5.671526e-05 3.151722e-04 12 38652203 38652357 155 - 0.000 0.961 16.942
ENSG00000139117 E003 99.9697732 0.0114265223 6.406326e-12 1.376187e-10 12 38652358 38653370 1013 - 1.771 2.212 1.480
ENSG00000139117 E004 45.6787912 0.0005056597 1.814026e-04 8.839947e-04 12 38653371 38653833 463 - 1.490 1.764 0.935
ENSG00000139117 E005 31.0461801 0.0007143913 9.659954e-01 9.826295e-01 12 38653834 38653961 128 - 1.377 1.434 0.199
ENSG00000139117 E006 24.3169101 0.0009049290 4.111811e-01 5.547668e-01 12 38653962 38654070 109 - 1.288 1.266 -0.077
ENSG00000139117 E007 12.7238344 0.0080368451 5.925644e-01 7.150973e-01 12 38670729 38670756 28 - 0.997 1.111 0.415
ENSG00000139117 E008 15.3312545 0.0145190526 5.931007e-01 7.155576e-01 12 38670757 38670802 46 - 1.072 1.185 0.404
ENSG00000139117 E009 0.6717251 0.0287334943 6.298319e-01 7.451431e-01 12 38670803 38670995 193 - 0.146 0.254 0.990
ENSG00000139117 E010 18.7166653 0.0044486821 8.482729e-01 9.057759e-01 12 38675717 38675774 58 - 1.173 1.206 0.118
ENSG00000139117 E011 24.9368538 0.0041106423 2.528645e-01 3.892991e-01 12 38677452 38677554 103 - 1.303 1.247 -0.196
ENSG00000139117 E012 0.2955422 0.0289152396 2.294534e-01   12 38679578 38679678 101 - 0.054 0.253 2.570
ENSG00000139117 E013 27.6375349 0.0011157935 8.051930e-02 1.603639e-01 12 38685490 38685617 128 - 1.352 1.247 -0.366
ENSG00000139117 E014 0.4460135 0.0423368249 1.000000e+00 1.000000e+00 12 38685618 38685694 77 - 0.146 0.000 -10.354
ENSG00000139117 E015 37.6043908 0.0015074333 9.335464e-01 9.621242e-01 12 38693657 38693838 182 - 1.455 1.515 0.208
ENSG00000139117 E016 20.0544071 0.0020870532 2.344086e-01 3.676433e-01 12 38702875 38702921 47 - 1.172 1.335 0.573
ENSG00000139117 E017 0.1472490 0.0460783678 1.000000e+00   12 38720653 38721222 570 - 0.054 0.000 -8.769
ENSG00000139117 E018 16.0308617 0.0040782782 7.018729e-02 1.436699e-01 12 38723772 38723833 62 - 1.067 1.302 0.835
ENSG00000139117 E019 16.0659786 0.0011443587 4.362314e-01 5.783296e-01 12 38724846 38724899 54 - 1.119 1.083 -0.128
ENSG00000139117 E020 0.0000000       12 38726359 38726594 236 -      
ENSG00000139117 E021 21.6454422 0.0008876944 2.737959e-03 9.486759e-03 12 38730283 38730358 76 - 1.270 0.988 -1.012
ENSG00000139117 E022 20.6000885 0.0014193687 5.890067e-03 1.832237e-02 12 38760847 38760888 42 - 1.248 0.988 -0.934
ENSG00000139117 E023 24.7473889 0.0008048859 1.633535e-03 6.068601e-03 12 38762112 38762216 105 - 1.328 1.054 -0.975
ENSG00000139117 E024 20.7802682 0.0008838251 2.451251e-02 6.087703e-02 12 38767635 38767690 56 - 1.244 1.054 -0.681
ENSG00000139117 E025 23.0708392 0.0008186700 8.421730e-02 1.661655e-01 12 38767691 38767738 48 - 1.279 1.161 -0.417
ENSG00000139117 E026 24.2352155 0.0008559130 2.569218e-02 6.330304e-02 12 38776238 38776301 64 - 1.306 1.137 -0.597
ENSG00000139117 E027 28.6101926 0.0006951982 1.594797e-02 4.261527e-02 12 38829379 38829455 77 - 1.374 1.206 -0.589
ENSG00000139117 E028 19.8482875 0.0009419898 1.860821e-02 4.847129e-02 12 38839916 38839955 40 - 1.231 1.022 -0.750
ENSG00000139117 E029 24.1194071 0.0008174807 1.274147e-04 6.474178e-04 12 38848559 38848662 104 - 1.325 0.951 -1.344
ENSG00000139117 E030 15.2734883 0.0011336188 9.466647e-05 4.969734e-04 12 38873004 38873050 47 - 1.148 0.621 -2.042
ENSG00000139117 E031 14.1725984 0.0012346165 4.336590e-03 1.408724e-02 12 38874471 38874511 41 - 1.105 0.761 -1.302
ENSG00000139117 E032 17.1890103 0.0011105055 7.317080e-05 3.954467e-04 12 38905437 38905591 155 - 1.195 0.696 -1.887
ENSG00000139117 E033 0.7406253 0.0153752265 4.387469e-01 5.805939e-01 12 38906142 38906269 128 - 0.222 0.000 -11.091
ENSG00000139117 E034 0.0000000       12 38907319 38907430 112 -