ENSG00000139116

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000544797 ENSG00000139116 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF21A protein_coding protein_coding 6.430341 2.23044 9.215061 0.03211409 0.08804722 2.041776 1.2436985 0.0000000 2.0997771 0.0000000 0.1633709 7.7209468 0.1335917 0.00000000 0.22760000 0.2276000 2.278115e-12 2.278115e-12 FALSE TRUE
ENST00000551264 ENSG00000139116 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF21A protein_coding protein_coding 6.430341 2.23044 9.215061 0.03211409 0.08804722 2.041776 1.4357768 1.3912761 0.5356651 0.1068941 0.2684960 -1.3606537 0.3500292 0.62370000 0.05766667 -0.5660333 1.087188e-02 2.278115e-12 FALSE TRUE
MSTRG.7117.1 ENSG00000139116 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF21A protein_coding   6.430341 2.23044 9.215061 0.03211409 0.08804722 2.041776 0.7016178 0.6233267 1.0119069 0.2248746 0.5106099 0.6902421 0.1599167 0.28030000 0.10960000 -0.1707000 6.333255e-01 2.278115e-12 FALSE TRUE
MSTRG.7117.6 ENSG00000139116 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF21A protein_coding   6.430341 2.23044 9.215061 0.03211409 0.08804722 2.041776 2.0665053 0.1054110 3.8240650 0.1054110 0.8031433 5.0540222 0.2247125 0.04686667 0.41670000 0.3698333 3.299222e-02 2.278115e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139116 E001 0.0000000       12 39293228 39293228 1 -      
ENSG00000139116 E002 0.0000000       12 39293229 39293230 2 -      
ENSG00000139116 E003 41.2508670 0.0554587045 1.378148e-10 2.375885e-09 12 39293231 39293606 376 - 1.194 2.044 2.905
ENSG00000139116 E004 28.9402664 0.0215583976 6.667249e-14 1.941722e-12 12 39293607 39293729 123 - 1.113 1.853 2.555
ENSG00000139116 E005 84.5736019 0.0034764432 1.645375e-18 8.822849e-17 12 39293730 39294278 549 - 1.698 2.150 1.522
ENSG00000139116 E006 33.6342913 0.0054271218 2.868476e-02 6.937447e-02 12 39294279 39294386 108 - 1.387 1.587 0.689
ENSG00000139116 E007 25.4893387 0.0130959472 2.521061e-01 3.884281e-01 12 39294387 39294423 37 - 1.285 1.426 0.490
ENSG00000139116 E008 34.5548772 0.0079496514 4.049963e-01 5.486729e-01 12 39294424 39294517 94 - 1.423 1.523 0.346
ENSG00000139116 E009 48.2721055 0.0005040984 1.678776e-01 2.854274e-01 12 39301480 39301679 200 - 1.561 1.678 0.399
ENSG00000139116 E010 44.5581844 0.0005207679 3.663714e-02 8.478074e-02 12 39302965 39303135 171 - 1.514 1.678 0.557
ENSG00000139116 E011 34.0663435 0.0057706738 2.080767e-01 3.361701e-01 12 39304821 39304938 118 - 1.409 1.543 0.459
ENSG00000139116 E012 44.8301667 0.0005043538 8.158986e-01 8.834665e-01 12 39307565 39307729 165 - 1.552 1.569 0.058
ENSG00000139116 E013 47.7699910 0.0004776898 5.732455e-01 6.992128e-01 12 39309586 39309751 166 - 1.582 1.578 -0.014
ENSG00000139116 E014 18.3655308 0.0010008759 6.342815e-01 7.487847e-01 12 39309752 39309766 15 - 1.166 1.244 0.276
ENSG00000139116 E015 0.2924217 0.0290785164 1.000000e+00   12 39311415 39311416 2 - 0.108 0.000 -10.894
ENSG00000139116 E016 36.8724342 0.0005419425 5.179444e-01 6.522589e-01 12 39311417 39311553 137 - 1.454 1.533 0.268
ENSG00000139116 E017 2.5057647 0.0060532086 2.400323e-02 5.981769e-02 12 39311554 39312826 1273 - 0.531 0.000 -13.982
ENSG00000139116 E018 0.3030308 0.3765751787 1.000000e+00   12 39315229 39315240 12 - 0.108 0.000 -10.901
ENSG00000139116 E019 0.1515154 0.0429713926 1.000000e+00   12 39315241 39315243 3 - 0.057 0.000 -9.895
ENSG00000139116 E020 0.8962933 0.1280276956 3.339876e-01 4.777552e-01 12 39315932 39315970 39 - 0.266 0.000 -12.482
ENSG00000139116 E021 15.8617882 0.0245287927 2.662174e-01 4.043862e-01 12 39318073 39318201 129 - 1.079 1.250 0.613
ENSG00000139116 E022 33.1030288 0.0008017501 3.542631e-01 4.985447e-01 12 39319906 39319989 84 - 1.402 1.503 0.348
ENSG00000139116 E023 22.9170659 0.0082114786 4.234160e-01 5.664614e-01 12 39319990 39320013 24 - 1.279 1.226 -0.186
ENSG00000139116 E024 8.7955959 0.0231071953 2.068869e-01 3.348321e-01 12 39321348 39322667 1320 - 0.921 0.741 -0.702
ENSG00000139116 E025 53.0388176 0.0004545507 2.291612e-01 3.614332e-01 12 39322668 39322882 215 - 1.601 1.704 0.352
ENSG00000139116 E026 26.7980014 0.0088327553 2.828968e-01 4.229588e-01 12 39325839 39325893 55 - 1.308 1.438 0.450
ENSG00000139116 E027 27.2844146 0.0007618944 8.473442e-01 9.051873e-01 12 39326264 39326324 61 - 1.342 1.358 0.055
ENSG00000139116 E028 1.0716550 0.0122445724 8.675306e-01 9.188238e-01 12 39330052 39330241 190 - 0.266 0.244 -0.169
ENSG00000139116 E029 3.9116586 0.0049233732 3.978645e-02 9.062999e-02 12 39330242 39330262 21 - 0.655 0.244 -2.227
ENSG00000139116 E030 40.8640837 0.0005679775 4.276938e-01 5.705325e-01 12 39330746 39330911 166 - 1.516 1.492 -0.082
ENSG00000139116 E031 36.6734831 0.0030915265 3.792439e-01 5.235199e-01 12 39331690 39331791 102 - 1.473 1.437 -0.126
ENSG00000139116 E032 0.0000000       12 39331931 39332213 283 -      
ENSG00000139116 E033 56.5191556 0.0006396975 4.883976e-04 2.115738e-03 12 39332214 39332408 195 - 1.682 1.482 -0.682
ENSG00000139116 E034 47.9242416 0.0006071244 2.322625e-03 8.220726e-03 12 39332591 39332744 154 - 1.610 1.424 -0.636
ENSG00000139116 E035 37.9756222 0.0005643541 8.260626e-02 1.636173e-01 12 39332893 39333036 144 - 1.499 1.399 -0.345
ENSG00000139116 E036 25.6916218 0.0009129282 1.834688e-01 3.055541e-01 12 39333037 39333107 71 - 1.334 1.244 -0.314
ENSG00000139116 E037 26.0822273 0.0168070542 3.063632e-01 4.485303e-01 12 39333212 39333280 69 - 1.340 1.263 -0.267
ENSG00000139116 E038 32.6338863 0.0006170681 3.048675e-02 7.292086e-02 12 39337096 39337203 108 - 1.446 1.297 -0.518
ENSG00000139116 E039 0.0000000       12 39337204 39337541 338 -      
ENSG00000139116 E040 38.4345902 0.0005771472 9.053085e-03 2.641022e-02 12 39340165 39340364 200 - 1.516 1.343 -0.597
ENSG00000139116 E041 42.5906422 0.0049533298 9.752462e-02 1.867105e-01 12 39340906 39341094 189 - 1.547 1.449 -0.337
ENSG00000139116 E042 36.0971316 0.0006125490 7.416351e-01 8.307127e-01 12 39341505 39341622 118 - 1.463 1.471 0.027
ENSG00000139116 E043 28.4043312 0.0093167889 7.709538e-01 8.521389e-01 12 39342034 39342124 91 - 1.366 1.370 0.013
ENSG00000139116 E044 0.1515154 0.0429713926 1.000000e+00   12 39346466 39346504 39 - 0.057 0.000 -9.895
ENSG00000139116 E045 38.6946843 0.0020211916 2.949180e-03 1.011502e-02 12 39351777 39351980 204 - 1.525 1.313 -0.736
ENSG00000139116 E046 0.4439371 0.0215782046 7.913849e-01 8.665763e-01 12 39356600 39356831 232 - 0.153 0.000 -11.480
ENSG00000139116 E047 23.9812374 0.0009096796 3.198161e-02 7.582434e-02 12 39356832 39356895 64 - 1.319 1.139 -0.636
ENSG00000139116 E048 15.3420296 0.0050778391 1.069607e-01 2.010516e-01 12 39357248 39357250 3 - 1.136 0.967 -0.615
ENSG00000139116 E049 40.5531615 0.0005514583 8.424566e-04 3.410494e-03 12 39357251 39357437 187 - 1.545 1.313 -0.802
ENSG00000139116 E050 49.0212777 0.0004687708 3.097270e-06 2.309748e-05 12 39358178 39358373 196 - 1.635 1.313 -1.107
ENSG00000139116 E051 34.0766237 0.1102266045 7.049049e-03 2.135171e-02 12 39363098 39363213 116 - 1.493 1.060 -1.523
ENSG00000139116 E052 40.9472840 0.0405687175 5.706801e-04 2.424181e-03 12 39366350 39366517 168 - 1.567 1.145 -1.469
ENSG00000139116 E053 30.5254803 0.0058040524 2.527117e-04 1.186622e-03 12 39367030 39367164 135 - 1.437 1.090 -1.222
ENSG00000139116 E054 0.0000000       12 39367165 39367188 24 -      
ENSG00000139116 E055 28.0318849 0.0009789787 2.597353e-05 1.568871e-04 12 39367883 39368032 150 - 1.407 1.001 -1.442
ENSG00000139116 E056 31.0067762 0.0006720647 6.367467e-06 4.427684e-05 12 39369729 39369911 183 - 1.450 1.032 -1.476
ENSG00000139116 E057 31.0040701 0.0006249456 3.768601e-04 1.684798e-03 12 39370039 39370261 223 - 1.439 1.139 -1.051
ENSG00000139116 E058 15.7576252 0.0011181757 7.898885e-02 1.578968e-01 12 39442927 39443390 464 - 1.145 0.967 -0.648