ENSG00000139044

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000266383 ENSG00000139044 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALNT3 protein_coding protein_coding 14.03439 17.22254 12.62049 0.9890237 0.7110283 -0.4482245 1.7235223 1.7856883 1.8057174 0.3913477 0.1646589 0.01600275 0.1221250 0.10176667 0.1441667 0.04240000 0.410090171 0.006692146 FALSE TRUE
ENST00000535680 ENSG00000139044 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALNT3 protein_coding retained_intron 14.03439 17.22254 12.62049 0.9890237 0.7110283 -0.4482245 1.1609495 0.3556515 1.5719721 0.1487382 0.5702385 2.11318309 0.0878375 0.01986667 0.1205333 0.10066667 0.006692146 0.006692146 FALSE FALSE
ENST00000647602 ENSG00000139044 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALNT3 protein_coding retained_intron 14.03439 17.22254 12.62049 0.9890237 0.7110283 -0.4482245 0.9405322 0.6271650 0.9220496 0.1206981 0.1287111 0.54873961 0.0696125 0.03596667 0.0733000 0.03733333 0.081382458 0.006692146 TRUE TRUE
MSTRG.6605.2 ENSG00000139044 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALNT3 protein_coding   14.03439 17.22254 12.62049 0.9890237 0.7110283 -0.4482245 7.3883431 11.0929621 6.0798467 0.8312862 0.5504390 -0.86646679 0.5164708 0.64300000 0.4837667 -0.15923333 0.069406348 0.006692146 FALSE TRUE
MSTRG.6605.3 ENSG00000139044 HEK293_OSMI2_2hA HEK293_TMG_2hB B4GALNT3 protein_coding   14.03439 17.22254 12.62049 0.9890237 0.7110283 -0.4482245 1.6939003 1.9368569 1.3172523 0.5254949 0.1315691 -0.55270416 0.1216917 0.11660000 0.1054333 -0.01116667 0.984342107 0.006692146 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000139044 E001 20.8694814 0.0124795568 1.411929e-03 5.346292e-03 12 459939 460451 513 + 1.456 1.208 -0.865
ENSG00000139044 E002 8.6763030 0.0481048635 1.333663e-01 2.388009e-01 12 460452 460469 18 + 1.060 0.887 -0.643
ENSG00000139044 E003 38.3254521 0.0085765490 1.119591e-02 3.163546e-02 12 460470 460545 76 + 1.656 1.517 -0.474
ENSG00000139044 E004 61.3386788 0.0004266428 9.603087e-05 5.034247e-04 12 535166 535269 104 + 1.856 1.720 -0.458
ENSG00000139044 E005 72.0931783 0.0004017912 4.117015e-05 2.366444e-04 12 536218 536295 78 + 1.923 1.793 -0.440
ENSG00000139044 E006 0.0000000       12 540463 540509 47 +      
ENSG00000139044 E007 0.0000000       12 543118 543132 15 +      
ENSG00000139044 E008 0.0000000       12 543133 543205 73 +      
ENSG00000139044 E009 66.1261150 0.0043076470 1.234127e-04 6.294637e-04 12 544339 544434 96 + 1.905 1.743 -0.545
ENSG00000139044 E010 69.3627610 0.0040955385 1.257398e-03 4.834599e-03 12 544882 544972 91 + 1.903 1.777 -0.422
ENSG00000139044 E011 1.9092774 0.1745043584 1.692561e-01 2.872157e-01 12 545140 545368 229 + 0.613 0.321 -1.502
ENSG00000139044 E012 74.3396027 0.0044057413 5.576956e-03 1.749292e-02 12 545369 545469 101 + 1.917 1.816 -0.339
ENSG00000139044 E013 68.8036007 0.0052878711 1.856763e-02 4.837956e-02 12 546646 546713 68 + 1.879 1.792 -0.291
ENSG00000139044 E014 6.3786182 0.0029228893 2.367194e-05 1.443658e-04 12 546714 546828 115 + 1.089 0.602 -1.911
ENSG00000139044 E015 14.0663130 0.0113347586 2.484330e-03 8.717335e-03 12 547639 548023 385 + 1.302 1.036 -0.949
ENSG00000139044 E016 69.4115060 0.0016820120 4.981836e-02 1.088373e-01 12 548024 548102 79 + 1.858 1.809 -0.168
ENSG00000139044 E017 65.0764705 0.0003966610 2.372085e-02 5.923631e-02 12 548231 548297 67 + 1.837 1.777 -0.201
ENSG00000139044 E018 0.4407149 0.0229306700 3.380708e-01 4.819422e-01 12 548298 548301 4 + 0.250 0.104 -1.515
ENSG00000139044 E019 98.1313116 0.0003317145 8.073618e-03 2.396770e-02 12 549769 549912 144 + 2.009 1.954 -0.186
ENSG00000139044 E020 87.8101467 0.0004827359 1.786319e-01 2.994398e-01 12 550922 551031 110 + 1.935 1.924 -0.039
ENSG00000139044 E021 47.2296160 0.0005217422 7.189321e-01 8.139187e-01 12 552063 552074 12 + 1.625 1.685 0.202
ENSG00000139044 E022 89.5249219 0.0003703192 2.304940e-02 5.785134e-02 12 552075 552163 89 + 1.964 1.918 -0.154
ENSG00000139044 E023 80.2078746 0.0020550057 9.684008e-02 1.856588e-01 12 552467 552528 62 + 1.907 1.874 -0.109
ENSG00000139044 E024 19.4511580 0.0009941410 3.633267e-05 2.115148e-04 12 552529 553190 662 + 1.444 1.165 -0.977
ENSG00000139044 E025 37.4354267 0.0052919729 5.889792e-01 7.121134e-01 12 553191 553193 3 + 1.556 1.561 0.018
ENSG00000139044 E026 391.3502861 0.0002231298 4.147413e-01 5.581418e-01 12 553194 553983 790 + 2.556 2.583 0.089
ENSG00000139044 E027 13.7648581 0.0014275636 5.158001e-01 6.504348e-01 12 553984 553988 5 + 1.089 1.189 0.357
ENSG00000139044 E028 17.2621280 0.0011392081 4.840773e-02 1.063418e-01 12 555290 555430 141 + 1.103 1.314 0.750
ENSG00000139044 E029 199.4171138 0.0001987436 8.287498e-01 8.924088e-01 12 556547 556866 320 + 2.259 2.294 0.120
ENSG00000139044 E030 123.4386261 0.0003071651 6.166044e-01 7.346274e-01 12 557608 557761 154 + 2.041 2.099 0.194
ENSG00000139044 E031 5.5575002 0.0043840701 4.565899e-01 5.969812e-01 12 557891 558015 125 + 0.835 0.771 -0.249
ENSG00000139044 E032 98.9161625 0.0010687072 7.797160e-01 8.583886e-01 12 558016 558088 73 + 1.949 2.001 0.176
ENSG00000139044 E033 137.6119399 0.0002850697 9.891398e-01 9.972676e-01 12 558508 558661 154 + 2.098 2.139 0.137
ENSG00000139044 E034 114.7898661 0.0003690088 2.706201e-01 4.092558e-01 12 559295 559421 127 + 1.992 2.072 0.267
ENSG00000139044 E035 902.3944240 0.0046277706 4.601086e-10 7.251763e-09 12 561343 563509 2167 + 2.792 3.007 0.715