ENSG00000138867

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435822 ENSG00000138867 HEK293_OSMI2_2hA HEK293_TMG_2hB GUCD1 protein_coding protein_coding 71.96213 139.9448 39.30979 3.745987 0.5689611 -1.831633 39.78908 69.77885 24.234282 4.406823 0.2522507 -1.525352 0.5818917 0.5006667 0.6167333 0.11606667 1.514019e-01 5.931048e-24 FALSE TRUE
ENST00000490922 ENSG00000138867 HEK293_OSMI2_2hA HEK293_TMG_2hB GUCD1 protein_coding processed_transcript 71.96213 139.9448 39.30979 3.745987 0.5689611 -1.831633 13.88968 41.29482 0.000000 9.316956 0.0000000 -12.012094 0.1227750 0.2926333 0.0000000 -0.29263333 5.931048e-24 5.931048e-24   FALSE
ENST00000621833 ENSG00000138867 HEK293_OSMI2_2hA HEK293_TMG_2hB GUCD1 protein_coding protein_coding 71.96213 139.9448 39.30979 3.745987 0.5689611 -1.831633 13.25455 23.26335 9.200168 2.089194 0.4748243 -1.337379 0.2015875 0.1661333 0.2338667 0.06773333 4.062440e-02 5.931048e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138867 E001 0.3299976 0.0277318026 7.807903e-01   22 24540423 24540437 15 - 0.001 0.139 7.685
ENSG00000138867 E002 3.2239423 0.5114568674 3.772319e-01 5.215670e-01 22 24540438 24540441 4 - 0.194 0.639 2.573
ENSG00000138867 E003 300.2965334 0.0047989637 8.138060e-02 1.617206e-01 22 24540442 24540531 90 - 2.308 2.416 0.361
ENSG00000138867 E004 664.3181709 0.0081022774 5.206677e-04 2.237065e-03 22 24540532 24540613 82 - 2.576 2.775 0.663
ENSG00000138867 E005 474.2187300 0.0081464562 3.825419e-03 1.265191e-02 22 24540614 24540619 6 - 2.448 2.626 0.591
ENSG00000138867 E006 818.6752036 0.0077213758 1.645881e-03 6.107759e-03 22 24540620 24540704 85 - 2.685 2.862 0.589
ENSG00000138867 E007 1611.5955546 0.0023684777 3.104240e-07 2.863000e-06 22 24540705 24540973 269 - 2.993 3.154 0.534
ENSG00000138867 E008 771.9368234 0.0005102949 5.589164e-07 4.899363e-06 22 24540974 24541062 89 - 2.698 2.827 0.429
ENSG00000138867 E009 2251.1024649 0.0010700457 6.417138e-03 1.970608e-02 22 24541063 24541967 905 - 3.204 3.284 0.266
ENSG00000138867 E010 1110.5068619 0.0015585169 6.236816e-01 7.402058e-01 22 24541968 24542397 430 - 2.941 2.966 0.082
ENSG00000138867 E011 789.3495318 0.0001461062 9.915813e-05 5.178984e-04 22 24542398 24542686 289 - 2.832 2.805 -0.088
ENSG00000138867 E012 428.5414284 0.0002370936 2.800538e-06 2.110483e-05 22 24542687 24542755 69 - 2.595 2.531 -0.212
ENSG00000138867 E013 407.8094400 0.0001408271 2.955879e-04 1.361892e-03 22 24542756 24542829 74 - 2.558 2.516 -0.140
ENSG00000138867 E014 439.2972389 0.0003512977 9.901259e-05 5.172095e-04 22 24542830 24542933 104 - 2.595 2.546 -0.164
ENSG00000138867 E015 571.6027051 0.0006586741 7.817898e-07 6.644435e-06 22 24542934 24543097 164 - 2.724 2.656 -0.225
ENSG00000138867 E016 24.6566451 0.0027798230 4.016313e-02 9.133975e-02 22 24543098 24543100 3 - 1.429 1.297 -0.459
ENSG00000138867 E017 466.3016162 0.0005211936 2.609813e-08 2.974321e-07 22 24543842 24543954 113 - 2.649 2.564 -0.283
ENSG00000138867 E018 330.2747482 0.0001863776 2.036931e-04 9.797408e-04 22 24543955 24544044 90 - 2.474 2.421 -0.176
ENSG00000138867 E019 232.5946069 0.0005412050 4.960389e-03 1.582065e-02 22 24544045 24544083 39 - 2.320 2.273 -0.159
ENSG00000138867 E020 195.4479083 0.0020649033 1.147873e-03 4.464314e-03 22 24546914 24546916 3 - 2.271 2.187 -0.279
ENSG00000138867 E021 366.6881538 0.0024585097 4.698518e-07 4.178379e-06 22 24546917 24547005 89 - 2.572 2.449 -0.409
ENSG00000138867 E022 8.4910962 0.0020178079 5.415501e-02 1.165230e-01 22 24547006 24547390 385 - 1.046 0.847 -0.748
ENSG00000138867 E023 3.0551140 0.0647103922 3.917755e-03 1.291221e-02 22 24547716 24547772 57 - 0.856 0.370 -2.203
ENSG00000138867 E024 4.7847724 0.1116680669 4.122256e-02 9.328886e-02 22 24547773 24547907 135 - 0.919 0.576 -1.400
ENSG00000138867 E025 452.2837527 0.0054106186 2.915489e-05 1.740008e-04 22 24547908 24548073 166 - 2.668 2.540 -0.427
ENSG00000138867 E026 272.4838621 0.0081140211 3.358475e-02 7.893762e-02 22 24548917 24549001 85 - 2.403 2.336 -0.226
ENSG00000138867 E027 137.5742448 0.0212901432 2.644452e-01 4.024164e-01 22 24554949 24555053 105 - 2.090 2.047 -0.145
ENSG00000138867 E028 91.9170586 0.0315032649 1.108401e-01 2.067781e-01 22 24555054 24555136 83 - 1.962 1.858 -0.349
ENSG00000138867 E029 12.4382208 0.0359502086 2.158024e-01 3.453696e-01 22 24555137 24555182 46 - 1.145 1.014 -0.472
ENSG00000138867 E030 185.7083389 0.0024194937 1.546150e-09 2.213675e-08 22 24555615 24555935 321 - 2.323 2.134 -0.629