ENSG00000138802

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265175 ENSG00000138802 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC24B protein_coding protein_coding 8.800433 4.302794 12.47884 0.1945275 0.1925053 1.533945 2.7910742 1.3375567 4.1258864 0.3901930 0.3652485 1.617851 0.3089125 0.3138333 0.3311667 0.01733333 9.237440e-01 2.370029e-08 FALSE TRUE
ENST00000399100 ENSG00000138802 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC24B protein_coding protein_coding 8.800433 4.302794 12.47884 0.1945275 0.1925053 1.533945 2.2835124 0.6235292 3.4674575 0.3702545 0.8539056 2.456550 0.2685375 0.1491000 0.2759000 0.12680000 6.251303e-01 2.370029e-08 FALSE TRUE
MSTRG.25299.4 ENSG00000138802 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC24B protein_coding   8.800433 4.302794 12.47884 0.1945275 0.1925053 1.533945 0.6038704 0.0000000 3.4734326 0.0000000 0.9122526 8.444366 0.0493000 0.0000000 0.2807000 0.28070000 2.370029e-08 2.370029e-08 FALSE TRUE
MSTRG.25299.5 ENSG00000138802 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC24B protein_coding   8.800433 4.302794 12.47884 0.1945275 0.1925053 1.533945 2.8538654 2.3417077 0.7858369 0.4478633 0.4287312 -1.563164 0.3430667 0.5371000 0.0626000 -0.47450000 5.442368e-02 2.370029e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138802 E001 1.034091 0.0116726494 3.973834e-01 5.411417e-01 4 109433772 109433812 41 + 0.342 0.185 -1.177
ENSG00000138802 E002 1.034091 0.0116726494 3.973834e-01 5.411417e-01 4 109433813 109433814 2 + 0.342 0.185 -1.177
ENSG00000138802 E003 1.185607 0.0108458237 2.994319e-01 4.409262e-01 4 109433815 109433825 11 + 0.380 0.185 -1.399
ENSG00000138802 E004 20.014766 0.0009386616 2.706669e-08 3.074531e-07 4 109433826 109434002 177 + 1.401 0.835 -2.050
ENSG00000138802 E005 1.186752 0.1690318927 8.011365e-02 1.597307e-01 4 109449417 109449439 23 + 0.415 0.000 -11.276
ENSG00000138802 E006 1.639109 0.0226992723 1.602555e-02 4.279180e-02 4 109449440 109449509 70 + 0.505 0.000 -11.735
ENSG00000138802 E007 176.793777 0.0002741030 1.449883e-24 1.520908e-22 4 109462901 109463644 744 + 2.294 1.977 -1.061
ENSG00000138802 E008 74.806714 0.0007825454 4.822911e-08 5.219572e-07 4 109473004 109473186 183 + 1.912 1.654 -0.873
ENSG00000138802 E009 19.200550 0.0439971042 2.086109e-01 3.368223e-01 4 109481677 109481781 105 + 1.313 1.160 -0.542
ENSG00000138802 E010 44.166440 0.0034854647 9.565315e-05 5.016250e-04 4 109491327 109491407 81 + 1.688 1.432 -0.875
ENSG00000138802 E011 85.271377 0.0004194195 1.502162e-06 1.201216e-05 4 109494615 109494856 242 + 1.956 1.754 -0.683
ENSG00000138802 E012 16.888560 0.0018192108 1.001019e-01 1.906314e-01 4 109506328 109506330 3 + 1.264 1.120 -0.510
ENSG00000138802 E013 81.454245 0.0004112317 7.591693e-04 3.112028e-03 4 109506331 109506512 182 + 1.923 1.785 -0.464
ENSG00000138802 E014 68.158241 0.0021445761 8.911672e-03 2.606069e-02 4 109510009 109510111 103 + 1.843 1.719 -0.418
ENSG00000138802 E015 76.454608 0.0091981757 1.564748e-01 2.704198e-01 4 109511957 109512083 127 + 1.879 1.803 -0.259
ENSG00000138802 E016 59.397380 0.0029808421 1.485244e-01 2.596645e-01 4 109513747 109513856 110 + 1.767 1.698 -0.236
ENSG00000138802 E017 65.004769 0.0003950486 2.579166e-01 3.950992e-01 4 109516528 109516640 113 + 1.800 1.758 -0.144
ENSG00000138802 E018 66.306789 0.0004117957 9.973813e-01 1.000000e+00 4 109520366 109520484 119 + 1.792 1.803 0.039
ENSG00000138802 E019 53.250254 0.0004739294 8.595468e-01 9.133917e-01 4 109521117 109521172 56 + 1.695 1.715 0.070
ENSG00000138802 E020 81.714947 0.0026107857 8.786988e-01 9.260911e-01 4 109521420 109521626 207 + 1.877 1.895 0.063
ENSG00000138802 E021 71.282591 0.0061113770 5.519707e-01 6.813568e-01 4 109524818 109524941 124 + 1.811 1.858 0.157
ENSG00000138802 E022 90.571494 0.0003532169 3.326386e-01 4.763147e-01 4 109525346 109525504 159 + 1.910 1.960 0.168
ENSG00000138802 E023 101.627453 0.0029294931 1.818866e-01 3.035882e-01 4 109526226 109526399 174 + 1.952 2.023 0.236
ENSG00000138802 E024 88.770692 0.0006385980 1.495270e-02 4.037835e-02 4 109527322 109527432 111 + 1.880 1.989 0.368
ENSG00000138802 E025 112.778239 0.0002835081 2.133195e-01 3.424474e-01 4 109530289 109530464 176 + 2.005 2.061 0.186
ENSG00000138802 E026 108.741694 0.0005808967 7.486858e-01 8.358444e-01 4 109531385 109531522 138 + 2.002 2.025 0.078
ENSG00000138802 E027 86.997497 0.0003307594 6.955035e-02 1.426186e-01 4 109532639 109532743 105 + 1.884 1.967 0.282
ENSG00000138802 E028 92.317954 0.0004553725 9.774168e-06 6.514748e-05 4 109533593 109533685 93 + 1.874 2.055 0.605
ENSG00000138802 E029 93.306535 0.0006001654 2.170017e-06 1.674487e-05 4 109538493 109538596 104 + 1.876 2.068 0.648
ENSG00000138802 E030 199.090888 0.0030011132 5.122815e-24 5.091826e-22 4 109539561 109540896 1336 + 2.123 2.480 1.193