ENSG00000138795

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379951 ENSG00000138795 HEK293_OSMI2_2hA HEK293_TMG_2hB LEF1 protein_coding protein_coding 13.39229 13.60712 12.83727 0.7281059 0.8158613 -0.08396008 3.8982170 2.554616 4.0183756 0.1170559 0.1524762 0.65145566 0.29045833 0.1881000 0.31610000 0.12800000 0.004446971 0.001948297 FALSE TRUE
ENST00000438313 ENSG00000138795 HEK293_OSMI2_2hA HEK293_TMG_2hB LEF1 protein_coding protein_coding 13.39229 13.60712 12.83727 0.7281059 0.8158613 -0.08396008 0.1356826 0.000000 0.7460784 0.0000000 0.3889868 6.24046400 0.01055833 0.0000000 0.05900000 0.05900000 0.179815891 0.001948297 FALSE TRUE
ENST00000503879 ENSG00000138795 HEK293_OSMI2_2hA HEK293_TMG_2hB LEF1 protein_coding processed_transcript 13.39229 13.60712 12.83727 0.7281059 0.8158613 -0.08396008 1.1005165 2.581775 0.2050611 0.6527436 0.2050611 -3.59112246 0.08315417 0.1873667 0.01646667 -0.17090000 0.033687050 0.001948297 FALSE TRUE
ENST00000504426 ENSG00000138795 HEK293_OSMI2_2hA HEK293_TMG_2hB LEF1 protein_coding processed_transcript 13.39229 13.60712 12.83727 0.7281059 0.8158613 -0.08396008 2.0696792 3.561022 1.3318096 0.5655855 0.7339888 -1.41215700 0.15982917 0.2589000 0.10050000 -0.15840000 0.512947374 0.001948297 FALSE FALSE
ENST00000505379 ENSG00000138795 HEK293_OSMI2_2hA HEK293_TMG_2hB LEF1 protein_coding processed_transcript 13.39229 13.60712 12.83727 0.7281059 0.8158613 -0.08396008 0.4592815 0.000000 1.0019335 0.0000000 0.5049242 6.66097062 0.03332083 0.0000000 0.07460000 0.07460000 0.167461562 0.001948297 FALSE TRUE
ENST00000510135 ENSG00000138795 HEK293_OSMI2_2hA HEK293_TMG_2hB LEF1 protein_coding processed_transcript 13.39229 13.60712 12.83727 0.7281059 0.8158613 -0.08396008 4.5260360 3.694875 3.8333991 0.2973309 0.1566330 0.05295797 0.33300000 0.2720333 0.30020000 0.02816667 0.725763753 0.001948297 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138795 E001 0.2214452 0.0393048223 5.169044e-01   4 108047545 108047547 3 - 0.000 0.120 11.607
ENSG00000138795 E002 1.2909195 0.0104217753 4.838140e-03 1.548079e-02 4 108047548 108047572 25 - 0.000 0.508 14.419
ENSG00000138795 E003 11.8508443 0.0015186135 7.396929e-06 5.062777e-05 4 108047573 108047591 19 - 0.779 1.258 1.774
ENSG00000138795 E004 169.4485571 0.0072690568 7.536723e-10 1.143986e-08 4 108047592 108048168 577 - 2.033 2.340 1.029
ENSG00000138795 E005 52.3457488 0.0073182495 9.853791e-03 2.840492e-02 4 108048169 108048299 131 - 1.620 1.790 0.575
ENSG00000138795 E006 53.7240489 0.0010080250 4.598253e-01 5.999031e-01 4 108048300 108048353 54 - 1.711 1.757 0.155
ENSG00000138795 E007 45.5208739 0.0005413393 3.190912e-01 4.621237e-01 4 108048354 108048376 23 - 1.631 1.692 0.208
ENSG00000138795 E008 49.4926507 0.0005752142 3.311210e-01 4.747048e-01 4 108048377 108048416 40 - 1.667 1.724 0.196
ENSG00000138795 E009 65.4124290 0.0008588499 6.812943e-01 7.850224e-01 4 108048417 108048526 110 - 1.822 1.814 -0.030
ENSG00000138795 E010 70.0089921 0.0003533956 8.340481e-01 8.960717e-01 4 108048527 108048596 70 - 1.837 1.856 0.062
ENSG00000138795 E011 61.0325646 0.0003959696 3.991410e-01 5.428757e-01 4 108048597 108048634 38 - 1.764 1.811 0.159
ENSG00000138795 E012 45.1536851 0.0005167049 6.622435e-01 7.705870e-01 4 108048635 108048638 4 - 1.673 1.660 -0.043
ENSG00000138795 E013 89.7420934 0.0003297229 4.589115e-01 5.991517e-01 4 108048639 108048751 113 - 1.966 1.949 -0.058
ENSG00000138795 E014 0.6235652 0.0202130879 2.832127e-01 4.233075e-01 4 108048752 108048774 23 - 0.301 0.120 -1.658
ENSG00000138795 E015 33.0180227 0.0052863443 6.912911e-01 7.927976e-01 4 108063623 108063628 6 - 1.506 1.540 0.120
ENSG00000138795 E016 41.2966594 0.0011081485 3.179827e-01 4.608989e-01 4 108063629 108063657 29 - 1.580 1.645 0.221
ENSG00000138795 E017 26.9363863 0.0007216281 2.101364e-01 3.387022e-01 4 108063658 108063663 6 - 1.387 1.480 0.321
ENSG00000138795 E018 57.4260018 0.0004622660 2.320994e-01 3.649371e-01 4 108064336 108064384 49 - 1.725 1.790 0.218
ENSG00000138795 E019 0.5181333 0.0203714550 5.279580e-01 6.608921e-01 4 108070430 108070661 232 - 0.222 0.120 -1.072
ENSG00000138795 E020 0.2966881 0.0290785164 1.830069e-01   4 108070662 108070662 1 - 0.222 0.000 -13.033
ENSG00000138795 E021 79.8007214 0.0003945631 5.990213e-01 7.205109e-01 4 108070663 108070770 108 - 1.909 1.898 -0.038
ENSG00000138795 E022 0.4772466 0.0207899421 6.115681e-01 7.306582e-01 4 108070771 108070895 125 - 0.125 0.213 0.925
ENSG00000138795 E023 0.4804688 0.0223518939 5.272062e-01 6.603305e-01 4 108071658 108071743 86 - 0.222 0.120 -1.074
ENSG00000138795 E024 0.0000000       4 108071744 108071778 35 -      
ENSG00000138795 E025 0.4439371 0.0215892170 7.383208e-02 1.496449e-01 4 108072003 108072133 131 - 0.301 0.000 -13.618
ENSG00000138795 E026 0.4439371 0.0215892170 7.383208e-02 1.496449e-01 4 108072134 108072251 118 - 0.301 0.000 -13.618
ENSG00000138795 E027 1.1426420 0.4189003249 6.569037e-01 7.663580e-01 4 108072837 108072896 60 - 0.369 0.293 -0.479
ENSG00000138795 E028 0.3697384 0.0274424043 2.202535e-01 3.507213e-01 4 108075375 108075477 103 - 0.000 0.213 12.611
ENSG00000138795 E029 68.7130422 0.0003837893 3.225219e-01 4.658226e-01 4 108078220 108078324 105 - 1.856 1.824 -0.108
ENSG00000138795 E030 68.0481330 0.0007653782 1.078972e-02 3.066288e-02 4 108078325 108078382 58 - 1.891 1.791 -0.335
ENSG00000138795 E031 0.0000000       4 108078383 108078462 80 -      
ENSG00000138795 E032 88.3187751 0.0006603600 5.273312e-02 1.140140e-01 4 108079492 108079614 123 - 1.984 1.921 -0.212
ENSG00000138795 E033 0.1472490 0.0439279923 4.592097e-01   4 108081584 108081585 2 - 0.125 0.000 -12.033
ENSG00000138795 E034 3.0677254 0.0052532060 4.030130e-01 5.468115e-01 4 108081586 108081620 35 - 0.670 0.549 -0.533
ENSG00000138795 E035 3.7204459 0.0656816610 8.175234e-01 8.846242e-01 4 108081621 108081669 49 - 0.638 0.685 0.202
ENSG00000138795 E036 1.0361649 0.0130250380 4.682992e-01 6.077191e-01 4 108083213 108083355 143 - 0.222 0.356 0.927
ENSG00000138795 E037 41.2923423 0.0102703413 7.903141e-01 8.658442e-01 4 108083356 108083367 12 - 1.607 1.633 0.090
ENSG00000138795 E038 75.3147263 0.0017216652 5.154987e-01 6.501716e-01 4 108083368 108083446 79 - 1.887 1.868 -0.065
ENSG00000138795 E039 81.2589802 0.0003736776 3.953001e-01 5.391186e-01 4 108089125 108089257 133 - 1.923 1.900 -0.079
ENSG00000138795 E040 75.5141802 0.0007593745 5.441036e-02 1.169728e-01 4 108163568 108163701 134 - 1.914 1.844 -0.236
ENSG00000138795 E041 57.0824464 0.0005753308 1.378904e-02 3.774716e-02 4 108165097 108165163 67 - 1.814 1.709 -0.354
ENSG00000138795 E042 0.0000000       4 108165164 108165257 94 -      
ENSG00000138795 E043 4.5458528 0.0043596750 9.306574e-02 1.799168e-01 4 108166272 108166657 386 - 0.846 0.621 -0.921
ENSG00000138795 E044 1.6877421 0.0449946211 6.218156e-01 7.387409e-01 4 108166658 108166797 140 - 0.368 0.464 0.515
ENSG00000138795 E045 136.8742286 0.0041222732 6.299094e-11 1.148219e-09 4 108167555 108168956 1402 - 2.262 2.002 -0.872