ENSG00000138780

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394730 ENSG00000138780 HEK293_OSMI2_2hA HEK293_TMG_2hB GSTCD protein_coding protein_coding 7.479921 1.72953 12.67062 0.3966856 0.4358858 2.865856 0.17948181 0.0000000 0.7410266 0.0000000 0.4408842 6.2307922 0.01371250 0.0000000 0.05853333 0.05853333 0.54498877 0.01267206 FALSE TRUE
ENST00000503409 ENSG00000138780 HEK293_OSMI2_2hA HEK293_TMG_2hB GSTCD protein_coding retained_intron 7.479921 1.72953 12.67062 0.3966856 0.4358858 2.865856 0.77071469 0.0000000 0.7417134 0.0000000 0.7417134 6.2321107 0.05934167 0.0000000 0.05650000 0.05650000 1.00000000 0.01267206 FALSE FALSE
ENST00000510865 ENSG00000138780 HEK293_OSMI2_2hA HEK293_TMG_2hB GSTCD protein_coding protein_coding 7.479921 1.72953 12.67062 0.3966856 0.4358858 2.865856 0.47081002 0.0000000 1.3304009 0.0000000 0.6780409 7.0665207 0.03400000 0.0000000 0.10656667 0.10656667 0.46495743 0.01267206 FALSE TRUE
ENST00000515255 ENSG00000138780 HEK293_OSMI2_2hA HEK293_TMG_2hB GSTCD protein_coding processed_transcript 7.479921 1.72953 12.67062 0.3966856 0.4358858 2.865856 0.09476558 0.4702616 0.0000000 0.3075674 0.0000000 -5.5857485 0.05741250 0.2311333 0.00000000 -0.23113333 0.01482523 0.01267206 FALSE TRUE
ENST00000515279 ENSG00000138780 HEK293_OSMI2_2hA HEK293_TMG_2hB GSTCD protein_coding protein_coding 7.479921 1.72953 12.67062 0.3966856 0.4358858 2.865856 5.01345384 1.0146052 8.4084569 0.1694528 0.5477775 3.0384877 0.67225417 0.6018000 0.66410000 0.06230000 0.67194626 0.01267206 FALSE TRUE
MSTRG.25272.8 ENSG00000138780 HEK293_OSMI2_2hA HEK293_TMG_2hB GSTCD protein_coding   7.479921 1.72953 12.67062 0.3966856 0.4358858 2.865856 0.18221802 0.1748200 0.2093433 0.1748200 0.2093433 0.2470698 0.03731667 0.1283000 0.01596667 -0.11233333 0.80472965 0.01267206 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138780 E001 0.1472490 0.0471814813 8.046213e-01   4 105708778 105708783 6 + 0.052 0.000 -7.141
ENSG00000138780 E002 0.1472490 0.0471814813 8.046213e-01   4 105708784 105708786 3 + 0.052 0.000 -8.902
ENSG00000138780 E003 24.9867426 0.0037039831 1.447549e-01 2.544952e-01 4 105708787 105708924 138 + 1.303 1.132 -0.604
ENSG00000138780 E004 21.1556124 0.0039939086 1.187039e-01 2.180832e-01 4 105708925 105708967 43 + 1.238 1.043 -0.700
ENSG00000138780 E005 18.5587883 0.0012264738 4.677921e-02 1.034299e-01 4 105708968 105708969 2 + 1.191 0.931 -0.948
ENSG00000138780 E006 25.8249487 0.0014290878 2.811615e-02 6.824332e-02 4 105708970 105709016 47 + 1.324 1.075 -0.885
ENSG00000138780 E007 1.9919083 0.0079484384 7.825064e-01 8.603602e-01 4 105709017 105709206 190 + 0.379 0.427 0.269
ENSG00000138780 E008 0.0000000       4 105710810 105710812 3 +      
ENSG00000138780 E009 0.0000000       4 105710813 105710845 33 +      
ENSG00000138780 E010 0.0000000       4 105710846 105710863 18 +      
ENSG00000138780 E011 0.0000000       4 105710864 105710869 6 +      
ENSG00000138780 E012 0.0000000       4 105710870 105711040 171 +      
ENSG00000138780 E013 0.0000000       4 105712511 105712602 92 +      
ENSG00000138780 E014 25.8520292 0.0008890603 9.114016e-02 1.769153e-01 4 105717593 105717625 33 + 1.319 1.132 -0.660
ENSG00000138780 E015 26.5907064 0.0032191719 4.019915e-02 9.140192e-02 4 105717626 105717709 84 + 1.337 1.104 -0.824
ENSG00000138780 E016 28.9337628 0.0007380433 2.009588e-01 3.273802e-01 4 105717710 105717778 69 + 1.362 1.228 -0.467
ENSG00000138780 E017 58.1019652 0.0005449855 9.658131e-02 1.852340e-01 4 105717779 105718039 261 + 1.652 1.527 -0.425
ENSG00000138780 E018 111.1163266 0.0288384060 4.642446e-02 1.028015e-01 4 105719060 105719527 468 + 1.936 1.720 -0.729
ENSG00000138780 E019 0.0000000       4 105719528 105719559 32 +      
ENSG00000138780 E020 86.0349451 0.0325075612 1.449577e-02 3.935202e-02 4 105726579 105726830 252 + 1.832 1.587 -0.831
ENSG00000138780 E021 48.3923144 0.0056186590 4.058654e-02 9.209594e-02 4 105729406 105729499 94 + 1.583 1.401 -0.624
ENSG00000138780 E022 0.1515154 0.0450108673 8.036632e-01   4 105761025 105761885 861 + 0.052 0.000 -8.919
ENSG00000138780 E023 42.2699805 0.0008306215 1.394020e-01 2.472247e-01 4 105822954 105823015 62 + 1.518 1.388 -0.448
ENSG00000138780 E024 32.7836049 0.0014876623 9.747265e-02 1.866298e-01 4 105823016 105823069 54 + 1.415 1.249 -0.579
ENSG00000138780 E025 2.9709201 0.0052762808 4.022325e-02 9.144245e-02 4 105823070 105823230 161 + 0.548 0.000 -13.242
ENSG00000138780 E026 29.6523255 0.0022344509 1.805186e-01 3.018341e-01 4 105823231 105823275 45 + 1.371 1.228 -0.500
ENSG00000138780 E027 0.7363589 0.0156979283 6.679192e-01 7.750539e-01 4 105823276 105823690 415 + 0.213 0.000 -11.425
ENSG00000138780 E028 44.4730892 0.0005327052 1.042856e-01 1.970143e-01 4 105825672 105825800 129 + 1.541 1.403 -0.475
ENSG00000138780 E029 42.1230849 0.0012478967 8.031071e-03 2.385859e-02 4 105834461 105834594 134 + 1.528 1.288 -0.830
ENSG00000138780 E030 26.9911483 0.0006930342 3.058550e-02 7.311552e-02 4 105837859 105837889 31 + 1.342 1.105 -0.840
ENSG00000138780 E031 39.5583131 0.0005561834 2.155684e-02 5.475910e-02 4 105842065 105842134 70 + 1.498 1.288 -0.725
ENSG00000138780 E032 283.2687898 0.0005906691 1.491912e-48 8.362079e-46 4 105845441 105847725 2285 + 2.254 2.566 1.041