ENSG00000138778

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
MSTRG.25259.10 ENSG00000138778 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPE protein_coding   9.462924 2.076731 15.31531 0.4018388 0.5341996 2.8766 3.1809563 1.34988873 4.3134263 0.34856265 0.1426495 1.6686865 0.43401250 0.63183333 0.28166667 -0.35016667 1.969724e-08 6.314392e-19 FALSE TRUE
MSTRG.25259.3 ENSG00000138778 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPE protein_coding   9.462924 2.076731 15.31531 0.4018388 0.5341996 2.8766 0.6502442 0.20367030 0.0000000 0.20367030 0.0000000 -4.4173145 0.09132917 0.09273333 0.00000000 -0.09273333 4.418612e-01 6.314392e-19 FALSE TRUE
MSTRG.25259.4 ENSG00000138778 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPE protein_coding   9.462924 2.076731 15.31531 0.4018388 0.5341996 2.8766 2.7524162 0.00000000 5.8216666 0.00000000 0.1987512 9.1877644 0.19164583 0.00000000 0.38133333 0.38133333 6.314392e-19 6.314392e-19 FALSE TRUE
MSTRG.25259.5 ENSG00000138778 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPE protein_coding   9.462924 2.076731 15.31531 0.4018388 0.5341996 2.8766 1.1034888 0.30615256 0.2687714 0.15784384 0.2687714 -0.1815383 0.13599583 0.16326667 0.01793333 -0.14533333 3.157502e-01 6.314392e-19 FALSE TRUE
MSTRG.25259.6 ENSG00000138778 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPE protein_coding   9.462924 2.076731 15.31531 0.4018388 0.5341996 2.8766 0.5489088 0.00000000 2.3171903 0.00000000 0.3246127 7.8624454 0.04171250 0.00000000 0.15223333 0.15223333 8.763999e-07 6.314392e-19 FALSE TRUE
MSTRG.25259.7 ENSG00000138778 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPE protein_coding   9.462924 2.076731 15.31531 0.4018388 0.5341996 2.8766 0.4055507 0.03199922 1.5023568 0.03199922 0.4721219 5.1702923 0.02884583 0.01456667 0.09650000 0.08193333 6.638092e-02 6.314392e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138778 E001 0.6266857 0.0171658463 6.475892e-02 1.346487e-01 4 103105349 103105810 462 - 0.091 0.449 2.956
ENSG00000138778 E002 1.5113352 0.0114929827 1.611716e-04 7.971876e-04 4 103105811 103105850 40 - 0.130 0.809 3.957
ENSG00000138778 E003 2.7916732 0.1302558873 1.122537e-05 7.372043e-05 4 103105851 103105947 97 - 0.199 1.069 4.203
ENSG00000138778 E004 2.0585261 0.2209039387 1.857753e-03 6.782013e-03 4 103105948 103105994 47 - 0.199 0.906 3.599
ENSG00000138778 E005 6.0206483 0.0080880988 6.572022e-02 1.362378e-01 4 103105995 103106012 18 - 0.654 0.962 1.219
ENSG00000138778 E006 16.1088307 0.0011404086 6.092661e-04 2.566795e-03 4 103106013 103106019 7 - 0.995 1.374 1.354
ENSG00000138778 E007 26.5323969 0.0007450429 1.708685e-08 2.017483e-07 4 103106020 103106046 27 - 1.177 1.649 1.635
ENSG00000138778 E008 119.8575671 0.0109631557 3.017896e-15 1.073472e-13 4 103106047 103106316 270 - 1.804 2.310 1.697
ENSG00000138778 E009 143.5208345 0.0002665503 1.825063e-36 4.953478e-34 4 103108803 103109089 287 - 1.889 2.358 1.571
ENSG00000138778 E010 96.4129397 0.0183363883 6.592999e-08 6.937094e-07 4 103110828 103111011 184 - 1.719 2.188 1.579
ENSG00000138778 E011 69.1452074 0.0217457860 7.585764e-04 3.110068e-03 4 103114455 103114552 98 - 1.609 1.965 1.204
ENSG00000138778 E012 0.2987644 0.0271393223 1.000000e+00   4 103116364 103116576 213 - 0.091 0.000 -8.199
ENSG00000138778 E013 83.5155835 0.0007519695 2.270073e-13 6.138433e-12 4 103116577 103116689 113 - 1.682 2.066 1.293
ENSG00000138778 E014 103.7942579 0.0003406308 4.740181e-09 6.214623e-08 4 103120148 103120333 186 - 1.802 2.092 0.973
ENSG00000138778 E015 105.6048384 0.0003299493 2.976811e-06 2.229043e-05 4 103122871 103123089 219 - 1.821 2.062 0.808
ENSG00000138778 E016 72.4864258 0.0004021587 4.811168e-05 2.722405e-04 4 103132693 103132896 204 - 1.658 1.908 0.843
ENSG00000138778 E017 75.7621149 0.0004146008 4.967857e-03 1.583967e-02 4 103133695 103133892 198 - 1.687 1.872 0.625
ENSG00000138778 E018 81.1107942 0.0158427509 8.037990e-02 1.601604e-01 4 103136141 103136359 219 - 1.714 1.910 0.659
ENSG00000138778 E019 53.8932192 0.0020083605 1.501126e-02 4.051340e-02 4 103138351 103138449 99 - 1.544 1.737 0.657
ENSG00000138778 E020 10.8878297 0.0017279246 1.414430e-02 3.855421e-02 4 103138450 103138452 3 - 0.864 1.191 1.202
ENSG00000138778 E021 3.3771756 0.0178591327 3.870387e-01 5.311893e-01 4 103139789 103140079 291 - 0.475 0.667 0.874
ENSG00000138778 E022 67.1785063 0.0003607327 2.606760e-02 6.408385e-02 4 103140256 103140414 159 - 1.642 1.803 0.546
ENSG00000138778 E023 85.9583440 0.0003813336 8.304553e-01 8.936358e-01 4 103140814 103141104 291 - 1.765 1.810 0.150
ENSG00000138778 E024 61.4242194 0.0003689200 4.238497e-01 5.668734e-01 4 103141750 103141908 159 - 1.633 1.612 -0.071
ENSG00000138778 E025 65.4523898 0.0006232458 3.267500e-01 4.701963e-01 4 103143248 103143406 159 - 1.662 1.631 -0.108
ENSG00000138778 E026 95.3186468 0.0003805686 9.301626e-02 1.798366e-01 4 103144331 103144618 288 - 1.825 1.765 -0.202
ENSG00000138778 E027 65.2623443 0.0009599479 1.142031e-02 3.216306e-02 4 103145050 103145302 253 - 1.673 1.527 -0.498
ENSG00000138778 E028 29.3056928 0.0015729693 4.383555e-02 9.808674e-02 4 103145303 103145334 32 - 1.343 1.164 -0.628
ENSG00000138778 E029 55.8934893 0.0409600046 2.268959e-01 3.586815e-01 4 103145523 103145681 159 - 1.604 1.508 -0.330
ENSG00000138778 E030 0.7490443 0.0706139180 6.593246e-01 7.681625e-01 4 103145682 103145781 100 - 0.200 0.000 -9.523
ENSG00000138778 E031 85.6050943 0.0011680557 1.317141e-01 2.365113e-01 4 103145829 103146107 279 - 1.779 1.722 -0.191
ENSG00000138778 E032 89.9914801 0.0017983625 2.215321e-02 5.599396e-02 4 103147356 103147646 291 - 1.807 1.699 -0.363
ENSG00000138778 E033 62.5934025 0.0005934083 1.763636e-03 6.483779e-03 4 103148844 103148999 156 - 1.661 1.464 -0.674
ENSG00000138778 E034 77.0326281 0.0003647340 4.256859e-03 1.386056e-02 4 103149118 103149408 291 - 1.744 1.592 -0.515
ENSG00000138778 E035 51.5939138 0.0005878788 9.123585e-04 3.657446e-03 4 103151219 103151377 159 - 1.581 1.340 -0.832
ENSG00000138778 E036 58.8044960 0.0004320402 6.805457e-05 3.707792e-04 4 103153047 103153250 204 - 1.641 1.357 -0.974
ENSG00000138778 E037 60.1227922 0.0003965379 7.991006e-07 6.775296e-06 4 103158300 103158458 159 - 1.658 1.282 -1.295
ENSG00000138778 E038 74.2836626 0.0004479339 1.995533e-08 2.327021e-07 4 103158614 103158886 273 - 1.749 1.357 -1.341
ENSG00000138778 E039 73.6752876 0.0003604765 3.274580e-09 4.410660e-08 4 103159010 103159324 315 - 1.746 1.321 -1.457
ENSG00000138778 E040 47.8735346 0.0005070772 1.223772e-07 1.222527e-06 4 103160625 103160779 155 - 1.567 1.075 -1.720
ENSG00000138778 E041 55.8369164 0.0004390284 3.830528e-08 4.225222e-07 4 103161086 103161251 166 - 1.630 1.164 -1.616
ENSG00000138778 E042 51.3349410 0.0004570656 1.018609e-10 1.794591e-09 4 103161335 103161457 123 - 1.605 0.962 -2.265
ENSG00000138778 E043 43.1813962 0.0005216820 6.518847e-09 8.323623e-08 4 103163137 103163256 120 - 1.531 0.917 -2.183
ENSG00000138778 E044 20.0918520 0.0079333108 2.655204e-04 1.239363e-03 4 103163479 103163553 75 - 1.209 0.666 -2.065
ENSG00000138778 E045 51.9149834 0.0004582583 1.784177e-12 4.194676e-11 4 103174736 103174903 168 - 1.612 0.866 -2.654
ENSG00000138778 E046 33.0566860 0.0007463045 8.182757e-09 1.025196e-07 4 103175960 103176048 89 - 1.423 0.665 -2.811
ENSG00000138778 E047 39.1323672 0.0005191848 2.371137e-08 2.724270e-07 4 103176899 103177039 141 - 1.488 0.866 -2.230
ENSG00000138778 E048 19.4392011 0.0009982667 2.057695e-04 9.887238e-04 4 103177040 103177046 7 - 1.196 0.665 -2.020
ENSG00000138778 E049 41.1278995 0.0077239771 3.741980e-07 3.393360e-06 4 103180311 103180469 159 - 1.509 0.917 -2.106
ENSG00000138778 E050 31.5441848 0.0010440433 4.686454e-06 3.357034e-05 4 103181337 103181456 120 - 1.397 0.866 -1.915
ENSG00000138778 E051 0.5943067 0.0283037435 4.595672e-01 5.996779e-01 4 103181457 103181963 507 - 0.130 0.280 1.369
ENSG00000138778 E052 33.3233069 0.0005706681 2.534801e-07 2.381878e-06 4 103182762 103182891 130 - 1.423 0.809 -2.226
ENSG00000138778 E053 26.6864872 0.0006975681 5.795885e-06 4.066048e-05 4 103183201 103183288 88 - 1.329 0.743 -2.164
ENSG00000138778 E054 21.7807138 0.0009353612 6.879081e-04 2.855061e-03 4 103185810 103185861 52 - 1.239 0.809 -1.588
ENSG00000138778 E055 19.4329210 0.0009265883 2.990463e-03 1.023641e-02 4 103194229 103194250 22 - 1.190 0.809 -1.412
ENSG00000138778 E056 26.6088544 0.0013300391 6.536995e-06 4.532662e-05 4 103194251 103194294 44 - 1.329 0.743 -2.164
ENSG00000138778 E057 37.8000358 0.0009210288 5.638326e-05 3.135664e-04 4 103194374 103194441 68 - 1.463 1.075 -1.365
ENSG00000138778 E058 36.7070112 0.0007850821 3.326127e-05 1.955938e-04 4 103194603 103194684 82 - 1.452 1.040 -1.454
ENSG00000138778 E059 39.3164526 0.0005380730 4.222978e-07 3.791434e-06 4 103195114 103195233 120 - 1.488 0.962 -1.868
ENSG00000138778 E060 35.1345405 0.0005481939 6.916850e-06 4.769515e-05 4 103195920 103196038 119 - 1.438 0.962 -1.693
ENSG00000138778 E061 27.5687202 0.0042970641 1.133052e-04 5.830594e-04 4 103196163 103196252 90 - 1.336 0.866 -1.703
ENSG00000138778 E062 25.2919039 0.0032500540 1.040249e-04 5.406156e-04 4 103196759 103196850 92 - 1.302 0.809 -1.807
ENSG00000138778 E063 14.5516663 0.0045241119 2.646508e-05 1.595104e-04 4 103198264 103198445 182 - 1.091 0.280 -3.643