ENSG00000138767

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000504123 ENSG00000138767 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT6L protein_coding protein_coding 6.281359 1.816805 11.02112 0.2180461 0.2006817 2.594185 1.87288940 0.86848510 3.414908 0.19424275 0.17996645 1.962976 0.376208333 0.47916667 0.3095000 -0.16966667 2.000841e-01 1.205343e-16 FALSE TRUE
ENST00000505983 ENSG00000138767 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT6L protein_coding processed_transcript 6.281359 1.816805 11.02112 0.2180461 0.2006817 2.594185 0.01885586 0.15084687 0.000000 0.15084687 0.00000000 -4.007616 0.009283333 0.07426667 0.0000000 -0.07426667 4.467806e-01 1.205343e-16 FALSE FALSE
ENST00000512485 ENSG00000138767 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT6L protein_coding protein_coding 6.281359 1.816805 11.02112 0.2180461 0.2006817 2.594185 2.45967201 0.05938433 4.503356 0.03064554 0.01333407 6.023447 0.259441667 0.02920000 0.4088333 0.37963333 1.205343e-16 1.205343e-16 FALSE TRUE
ENST00000515506 ENSG00000138767 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT6L protein_coding protein_coding 6.281359 1.816805 11.02112 0.2180461 0.2006817 2.594185 1.66525520 0.73808827 2.512115 0.03342708 0.17048785 1.753354 0.318454167 0.41740000 0.2276333 -0.18976667 1.036849e-02 1.205343e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138767 E001 244.0034551 0.0120825488 5.220464e-02 1.130778e-01 4 77713387 77718020 4634 - 2.270 2.387 0.389
ENSG00000138767 E002 251.4703469 0.0002939560 9.691294e-19 5.366812e-17 4 77718021 77720229 2209 - 2.256 2.478 0.740
ENSG00000138767 E003 11.9561548 0.0055849847 8.264165e-01 8.907641e-01 4 77720230 77720237 8 - 1.022 1.011 -0.042
ENSG00000138767 E004 61.8491279 0.0055337708 1.001637e-01 1.907279e-01 4 77720238 77720643 406 - 1.722 1.626 -0.325
ENSG00000138767 E005 0.0000000       4 77726166 77726166 1 -      
ENSG00000138767 E006 33.5327568 0.0005738612 1.566978e-01 2.707017e-01 4 77726167 77726305 139 - 1.464 1.376 -0.306
ENSG00000138767 E007 28.6733839 0.0171700482 4.317035e-01 5.742357e-01 4 77726306 77726369 64 - 1.392 1.322 -0.244
ENSG00000138767 E008 21.9865580 0.0188214915 8.268387e-01 8.910751e-01 4 77728854 77728876 23 - 1.272 1.258 -0.050
ENSG00000138767 E009 38.9141950 0.0005734477 9.027059e-01 9.420493e-01 4 77728877 77729081 205 - 1.507 1.519 0.041
ENSG00000138767 E010 43.2297192 0.0005960929 2.965609e-02 7.128954e-02 4 77731387 77731538 152 - 1.579 1.447 -0.450
ENSG00000138767 E011 0.1472490 0.0463196348 1.000000e+00   4 77731539 77731881 343 - 0.060 0.000 -8.149
ENSG00000138767 E012 32.2327659 0.0006678373 5.879413e-03 1.829501e-02 4 77742141 77742202 62 - 1.467 1.257 -0.729
ENSG00000138767 E013 38.6523130 0.0020859708 2.479131e-04 1.166490e-03 4 77742203 77742295 93 - 1.552 1.273 -0.965
ENSG00000138767 E014 0.4482035 0.0254679717 7.625258e-01 8.460962e-01 4 77742431 77742472 42 - 0.160 0.000 -9.996
ENSG00000138767 E015 44.7096772 0.0183736867 3.762165e-02 8.662157e-02 4 77744718 77744875 158 - 1.600 1.422 -0.610
ENSG00000138767 E016 34.6404299 0.0006334097 1.493190e-02 4.033255e-02 4 77748316 77748384 69 - 1.492 1.320 -0.595
ENSG00000138767 E017 35.0603666 0.0007864128 2.419959e-02 6.022067e-02 4 77756862 77756951 90 - 1.492 1.335 -0.544
ENSG00000138767 E018 33.6858937 0.0048932639 7.832472e-02 1.567877e-01 4 77773081 77773166 86 - 1.471 1.336 -0.468
ENSG00000138767 E019 43.6808033 0.0013674663 1.687977e-04 8.300426e-04 4 77774530 77774712 183 - 1.600 1.335 -0.914
ENSG00000138767 E020 14.7271762 0.0012138180 1.392749e-02 3.806182e-02 4 77774713 77774716 4 - 1.154 0.869 -1.050
ENSG00000138767 E021 23.6233207 0.0007993355 1.621848e-04 8.013936e-04 4 77776271 77776392 122 - 1.357 0.979 -1.349
ENSG00000138767 E022 0.2998086 0.0280813953 2.679506e-01   4 77818974 77819232 259 - 0.060 0.233 2.254
ENSG00000138767 E023 0.7363589 0.0157309386 3.691102e-01 5.135494e-01 4 77819233 77819303 71 - 0.242 0.000 -10.861
ENSG00000138767 E024 1.6263095 0.0087219363 7.562417e-02 1.525049e-01 4 77819304 77819376 73 - 0.421 0.000 -12.038
ENSG00000138767 E025 6.6871817 0.0024903312 2.727195e-02 6.654203e-02 4 77819590 77819676 87 - 0.861 0.496 -1.551