ENSG00000138758

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264893 ENSG00000138758 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN11 protein_coding protein_coding 33.80375 13.78314 58.13911 1.042243 1.339913 2.075806 26.299534 12.38802 42.73703 1.181611 1.4853641 1.785715 0.82439167 0.8964667 0.7347 -0.1617667 3.091677e-03 1.162688e-36 FALSE TRUE
MSTRG.25010.12 ENSG00000138758 HEK293_OSMI2_2hA HEK293_TMG_2hB SEPTIN11 protein_coding   33.80375 13.78314 58.13911 1.042243 1.339913 2.075806 5.206458 0.00000 11.55169 0.000000 0.5791309 10.175137 0.09573333 0.0000000 0.1990 0.1990000 1.162688e-36 1.162688e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138758 E001 0.3289534 0.0274424043 3.405309e-01   4 76949102 76949174 73 + 0.060 0.234 2.272
ENSG00000138758 E002 1.7905103 0.0997371203 5.006502e-02 1.092784e-01 4 76949751 76949751 1 + 0.444 0.000 -12.490
ENSG00000138758 E003 3.3353479 0.0044885537 2.576559e-02 6.345795e-02 4 76949752 76949761 10 + 0.614 0.234 -2.121
ENSG00000138758 E004 6.8586412 0.0046509101 7.497604e-02 1.514963e-01 4 76949762 76949765 4 + 0.840 0.660 -0.729
ENSG00000138758 E005 19.1136011 0.0009348529 4.042389e-05 2.327150e-04 4 76949766 76949808 43 + 1.263 0.911 -1.277
ENSG00000138758 E006 39.2753787 0.0079958516 1.800674e-03 6.601752e-03 4 76949809 76949835 27 + 1.537 1.379 -0.544
ENSG00000138758 E007 38.6905353 0.0058432858 1.564526e-03 5.844438e-03 4 76949836 76949836 1 + 1.530 1.379 -0.520
ENSG00000138758 E008 50.3034089 0.0033196630 1.882556e-06 1.473373e-05 4 76949837 76949861 25 + 1.654 1.416 -0.818
ENSG00000138758 E009 89.9493249 0.0008549134 2.183023e-15 7.892505e-14 4 76949862 76949930 69 + 1.912 1.590 -1.091
ENSG00000138758 E010 0.1515154 0.0426780174 1.000000e+00   4 76959228 76959252 25 + 0.060 0.000 -8.902
ENSG00000138758 E011 0.3729606 0.0266553781 3.389128e-01 4.828209e-01 4 76972390 76972590 201 + 0.060 0.235 2.273
ENSG00000138758 E012 0.0000000       4 76973010 76973070 61 +      
ENSG00000138758 E013 1.0299239 0.3738052063 5.494520e-01 6.791771e-01 4 76974478 76974807 330 + 0.202 0.397 1.339
ENSG00000138758 E014 0.0000000       4 76985024 76985123 100 +      
ENSG00000138758 E015 0.1482932 0.0408769788 1.191474e-01   4 76987788 76987808 21 + 0.000 0.234 13.165
ENSG00000138758 E016 0.1482932 0.0408769788 1.191474e-01   4 76987809 76987870 62 + 0.000 0.234 13.165
ENSG00000138758 E017 4.6078387 0.0108002313 2.794256e-04 1.296113e-03 4 76995781 76995938 158 + 0.748 0.000 -13.856
ENSG00000138758 E018 157.7395468 0.0033036963 4.422003e-12 9.743374e-11 4 76996425 76996539 115 + 2.142 1.926 -0.723
ENSG00000138758 E019 96.0414633 0.0004099124 8.585610e-10 1.287821e-08 4 77005601 77005609 9 + 1.925 1.743 -0.614
ENSG00000138758 E020 259.4303827 0.0005294823 1.421922e-12 3.396104e-11 4 77005610 77005796 187 + 2.338 2.244 -0.316
ENSG00000138758 E021 0.0000000       4 77009780 77009987 208 +      
ENSG00000138758 E022 309.5752113 0.0001651189 5.311614e-15 1.820314e-13 4 77011735 77011921 187 + 2.413 2.328 -0.284
ENSG00000138758 E023 139.8632600 0.0008307764 1.521548e-09 2.180759e-08 4 77014856 77014870 15 + 2.076 1.942 -0.450
ENSG00000138758 E024 290.9631329 0.0056228955 7.934737e-05 4.247986e-04 4 77014871 77015017 147 + 2.381 2.316 -0.217
ENSG00000138758 E025 226.8211383 0.0052527683 3.078786e-03 1.049721e-02 4 77019165 77019261 97 + 2.266 2.245 -0.071
ENSG00000138758 E026 132.9849995 0.0006421970 4.122868e-04 1.821513e-03 4 77020502 77020531 30 + 2.035 2.011 -0.080
ENSG00000138758 E027 314.1662142 0.0034719347 4.004510e-06 2.912754e-05 4 77020532 77020670 139 + 2.414 2.351 -0.210
ENSG00000138758 E028 6.9177464 0.0388592248 6.208826e-01 7.379333e-01 4 77020671 77021639 969 + 0.812 0.827 0.061
ENSG00000138758 E029 264.5646573 0.0029540968 1.048633e-06 8.663402e-06 4 77028629 77028716 88 + 2.342 2.268 -0.247
ENSG00000138758 E030 213.0437673 0.0015475882 2.376021e-07 2.244478e-06 4 77028717 77028761 45 + 2.249 2.177 -0.240
ENSG00000138758 E031 250.4656296 0.0009568838 1.271020e-07 1.265344e-06 4 77030783 77030896 114 + 2.314 2.263 -0.171
ENSG00000138758 E032 167.4208327 0.0002958514 7.176506e-04 2.962279e-03 4 77030897 77030970 74 + 2.130 2.132 0.006
ENSG00000138758 E033 14.5071414 0.0297731715 6.849006e-01 7.877243e-01 4 77030971 77032158 1188 + 1.062 1.225 0.585
ENSG00000138758 E034 394.0403513 0.0017292068 2.869698e-01 4.274261e-01 4 77034497 77034923 427 + 2.483 2.569 0.287
ENSG00000138758 E035 192.2248765 0.0002427768 2.798546e-01 4.196290e-01 4 77034924 77035020 97 + 2.173 2.258 0.284
ENSG00000138758 E036 1235.7748961 0.0018037551 4.204383e-01 5.636440e-01 4 77035021 77036769 1749 + 2.967 3.097 0.431
ENSG00000138758 E037 108.0380570 0.0056147097 5.888354e-03 1.831802e-02 4 77036770 77036772 3 + 1.879 2.138 0.866
ENSG00000138758 E038 164.7559471 0.0047975137 1.536035e-03 5.753436e-03 4 77036773 77036837 65 + 2.061 2.316 0.854
ENSG00000138758 E039 1420.8310702 0.0165639874 1.122659e-08 1.371184e-07 4 77036838 77038615 1778 + 2.940 3.344 1.341
ENSG00000138758 E040 8.0287318 0.0021294592 1.403050e-04 7.048996e-04 4 77039073 77039326 254 + 0.699 1.242 2.039
ENSG00000138758 E041 15.2239929 0.0034560125 1.018060e-18 5.619710e-17 4 77039743 77040384 642 + 0.736 1.642 3.271