ENSG00000138735

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264805 ENSG00000138735 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE5A protein_coding protein_coding 1.119347 0.3152378 1.573216 0.0703585 0.2495789 2.283292 0.17274671 0.07357837 0.24277332 0.03704077 0.12301279 1.5966427 0.18731250 0.22673333 0.1863333 -0.04040000 0.94028989 0.01531477 FALSE TRUE
ENST00000354960 ENSG00000138735 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE5A protein_coding protein_coding 1.119347 0.3152378 1.573216 0.0703585 0.2495789 2.283292 0.36942685 0.06906159 0.59121571 0.06906159 0.01053688 2.9268338 0.37007500 0.28096667 0.4012000 0.12023333 0.64624846 0.01531477 FALSE TRUE
ENST00000394439 ENSG00000138735 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE5A protein_coding protein_coding 1.119347 0.3152378 1.573216 0.0703585 0.2495789 2.283292 0.05445410 0.07209472 0.00000000 0.04061027 0.00000000 -3.0372895 0.12494167 0.20623333 0.0000000 -0.20623333 0.01746261 0.01531477 FALSE TRUE
ENST00000420633 ENSG00000138735 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE5A protein_coding protein_coding 1.119347 0.3152378 1.573216 0.0703585 0.2495789 2.283292 0.12065820 0.00000000 0.42912939 0.00000000 0.26661270 5.4565742 0.05985417 0.00000000 0.2312000 0.23120000 0.46776873 0.01531477 FALSE FALSE
ENST00000503412 ENSG00000138735 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE5A protein_coding protein_coding 1.119347 0.3152378 1.573216 0.0703585 0.2495789 2.283292 0.10433311 0.07873021 0.00000000 0.06046234 0.00000000 -3.1494253 0.07974167 0.19680000 0.0000000 -0.19680000 0.01531477 0.01531477 FALSE TRUE
ENST00000509612 ENSG00000138735 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE5A protein_coding retained_intron 1.119347 0.3152378 1.573216 0.0703585 0.2495789 2.283292 0.04514443 0.02177292 0.04977875 0.02177292 0.02507646 0.9118349 0.03337083 0.08923333 0.0380000 -0.05123333 0.89299307 0.01531477   FALSE
ENST00000512494 ENSG00000138735 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE5A protein_coding retained_intron 1.119347 0.3152378 1.573216 0.0703585 0.2495789 2.283292 0.14636109 0.00000000 0.20360914 0.00000000 0.12267702 4.4169015 0.05725833 0.00000000 0.1099667 0.10996667 0.54011679 0.01531477   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138735 E001 0.0000000       4 119494397 119494402 6 -      
ENSG00000138735 E002 32.3936718 0.039041950 0.541974716 0.67284066 4 119494403 119498540 4138 - 1.446 1.531 0.293
ENSG00000138735 E003 3.3340883 0.086405939 0.149742584 0.26132636 4 119498541 119498738 198 - 0.651 0.347 -1.507
ENSG00000138735 E004 0.5911836 0.020928489 0.005583322 0.01750912 4 119500823 119501169 347 - 0.000 0.452 13.235
ENSG00000138735 E005 2.7397936 0.005594000 0.523051962 0.65679911 4 119501170 119501253 84 - 0.557 0.452 -0.508
ENSG00000138735 E006 0.2924217 0.030086287 0.852328115   4 119502390 119502580 191 - 0.129 0.000 -9.858
ENSG00000138735 E007 3.6298434 0.004690357 0.527159447 0.66029379 4 119502581 119502655 75 - 0.633 0.537 -0.433
ENSG00000138735 E008 3.2245288 0.005124591 0.680639410 0.78449026 4 119504536 119504599 64 - 0.597 0.537 -0.274
ENSG00000138735 E009 4.5907810 0.004435943 0.791316096 0.86652598 4 119505855 119505932 78 - 0.698 0.669 -0.123
ENSG00000138735 E010 0.0000000       4 119505933 119505935 3 -      
ENSG00000138735 E011 3.4032119 0.005168928 0.903390492 0.94252493 4 119507604 119507652 49 - 0.577 0.608 0.138
ENSG00000138735 E012 3.4020660 0.005023352 0.533228165 0.66544894 4 119507653 119507704 52 - 0.557 0.669 0.494
ENSG00000138735 E013 4.2168874 0.004059470 0.614396700 0.73288216 4 119511047 119511134 88 - 0.633 0.722 0.375
ENSG00000138735 E014 0.0000000       4 119517060 119517124 65 -      
ENSG00000138735 E015 2.6323977 0.007877328 0.828493978 0.89221450 4 119519045 119519078 34 - 0.489 0.537 0.232
ENSG00000138735 E016 2.9194202 0.064497604 0.634195015 0.74874329 4 119519079 119519139 61 - 0.513 0.611 0.450
ENSG00000138735 E017 0.4783925 0.022490962 0.656044992 0.76580151 4 119519140 119519642 503 - 0.129 0.207 0.815
ENSG00000138735 E018 2.9903967 0.060714742 0.895019169 0.93691261 4 119520935 119520999 65 - 0.557 0.539 -0.084
ENSG00000138735 E019 3.1807200 0.010136454 0.377936458 0.52224634 4 119521000 119521060 61 - 0.513 0.670 0.703
ENSG00000138735 E020 4.4071141 0.003812128 0.527017201 0.66018546 4 119525549 119525695 147 - 0.698 0.608 -0.386
ENSG00000138735 E021 0.0000000       4 119527044 119527276 233 -      
ENSG00000138735 E022 0.2903454 0.329195583 1.000000000   4 119538781 119538842 62 - 0.129 0.000 -9.833
ENSG00000138735 E023 3.3894837 0.023733830 0.301753860 0.44356616 4 119538960 119539019 60 - 0.633 0.452 -0.845
ENSG00000138735 E024 0.0000000       4 119539020 119539098 79 -      
ENSG00000138735 E025 0.0000000       4 119541754 119542002 249 -      
ENSG00000138735 E026 4.4129763 0.040712446 0.768282418 0.85029556 4 119542459 119542634 176 - 0.666 0.724 0.238
ENSG00000138735 E027 0.0000000       4 119543094 119543297 204 -      
ENSG00000138735 E028 0.0000000       4 119552441 119552549 109 -      
ENSG00000138735 E029 3.3835449 0.043829662 0.973250720 0.98730915 4 119552550 119552637 88 - 0.597 0.606 0.041
ENSG00000138735 E030 6.3529508 0.015702618 0.932838280 0.96168157 4 119553638 119553746 109 - 0.816 0.813 -0.015
ENSG00000138735 E031 5.3553914 0.025426814 0.601742443 0.72282579 4 119560296 119560363 68 - 0.728 0.813 0.343
ENSG00000138735 E032 5.1132204 0.030773145 0.811004786 0.88013945 4 119562833 119562970 138 - 0.728 0.769 0.167
ENSG00000138735 E033 0.0000000       4 119562971 119562972 2 -      
ENSG00000138735 E034 4.1479026 0.004034138 0.949975829 0.97269027 4 119565321 119565410 90 - 0.667 0.668 0.006
ENSG00000138735 E035 4.3264734 0.003692801 0.867121246 0.91851425 4 119567073 119567144 72 - 0.683 0.669 -0.060
ENSG00000138735 E036 2.4723760 0.016084537 0.442766525 0.58433559 4 119596523 119596525 3 - 0.464 0.607 0.675
ENSG00000138735 E037 4.4684239 0.003849153 0.859077313 0.91306708 4 119596526 119596612 87 - 0.683 0.722 0.162
ENSG00000138735 E038 15.7311939 0.007179747 0.403991154 0.54773429 4 119606709 119607297 589 - 1.188 1.120 -0.241
ENSG00000138735 E039 0.3666179 0.027329886 0.370538338 0.51497199 4 119627150 119627633 484 - 0.069 0.207 1.817
ENSG00000138735 E040 0.1472490 0.044404914 1.000000000   4 119627995 119628084 90 - 0.069 0.000 -8.903
ENSG00000138735 E041 4.1738027 0.021639044 0.032414451 0.07665964 4 119628520 119628804 285 - 0.741 0.346 -1.887