ENSG00000138709

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394288 ENSG00000138709 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP1B protein_coding protein_coding 14.54048 8.424096 24.18393 0.008274874 0.8682357 1.52034 7.5067119 5.22346125 11.902942 0.08729675 0.29691319 1.186692 0.52580417 0.62006667 0.49300000 -0.127066667 0.0037480649 0.0003386984 FALSE TRUE
ENST00000432347 ENSG00000138709 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP1B protein_coding protein_coding 14.54048 8.424096 24.18393 0.008274874 0.8682357 1.52034 0.8587019 0.36183562 1.159112 0.20137905 0.61109479 1.652677 0.06928333 0.04300000 0.04623333 0.003233333 1.0000000000 0.0003386984 FALSE TRUE
ENST00000507377 ENSG00000138709 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP1B protein_coding protein_coding 14.54048 8.424096 24.18393 0.008274874 0.8682357 1.52034 0.8274279 0.16366423 1.877608 0.05166114 0.09982448 3.442187 0.05272917 0.01943333 0.07816667 0.058733333 0.0003386984 0.0003386984 FALSE TRUE
ENST00000512292 ENSG00000138709 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP1B protein_coding protein_coding 14.54048 8.424096 24.18393 0.008274874 0.8682357 1.52034 1.6057917 0.90008887 2.872464 0.04996060 0.12000004 1.663223 0.10494583 0.10690000 0.11940000 0.012500000 0.7968158055 0.0003386984 FALSE TRUE
ENST00000649983 ENSG00000138709 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP1B protein_coding protein_coding 14.54048 8.424096 24.18393 0.008274874 0.8682357 1.52034 0.6417905 0.08183395 1.462868 0.06084535 0.15338083 4.003457 0.03918750 0.00970000 0.06033333 0.050633333 0.0028733736 0.0003386984 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138709 E001 2.6392815 0.1917198945 3.046355e-01 4.466652e-01 4 128061076 128061225 150 + 0.580 0.334 -1.274
ENSG00000138709 E002 0.4439371 0.0215762819 4.078742e-01 5.514676e-01 4 128061266 128061285 20 + 0.194 0.000 -11.850
ENSG00000138709 E003 0.8856842 0.0802101124 1.360453e-01 2.425364e-01 4 128061286 128061293 8 + 0.327 0.000 -12.608
ENSG00000138709 E004 1.1781059 0.0771467845 7.183458e-02 1.463919e-01 4 128061294 128061295 2 + 0.398 0.000 -13.007
ENSG00000138709 E005 3.1052918 0.1523634958 9.209665e-01 9.541215e-01 4 128061296 128061311 16 + 0.582 0.582 0.000
ENSG00000138709 E006 7.3374967 0.0023931809 2.493994e-01 3.852166e-01 4 128061312 128061334 23 + 0.920 0.784 -0.526
ENSG00000138709 E007 11.9410638 0.0015058711 1.917123e-01 3.159108e-01 4 128061335 128061347 13 + 1.101 0.976 -0.458
ENSG00000138709 E008 23.5001738 0.0041770866 2.277648e-03 8.083100e-03 4 128061348 128061401 54 + 1.405 1.146 -0.909
ENSG00000138709 E009 4.3154170 0.0276455238 1.412566e-04 7.090037e-04 4 128061514 128061529 16 + 0.809 0.000 -14.791
ENSG00000138709 E010 13.2205428 0.0013193439 1.957910e-05 1.217329e-04 4 128061530 128061693 164 + 1.209 0.695 -1.943
ENSG00000138709 E011 18.1998228 0.0420225262 1.334258e-02 3.671759e-02 4 128061694 128061992 299 + 1.315 0.977 -1.211
ENSG00000138709 E012 26.4810955 0.0007332936 6.037728e-01 7.244792e-01 4 128061993 128062219 227 + 1.401 1.383 -0.064
ENSG00000138709 E013 55.2556307 0.0003975311 7.450116e-03 2.238544e-02 4 128074460 128074518 59 + 1.739 1.614 -0.425
ENSG00000138709 E014 66.2566994 0.0016491554 1.623076e-01 2.781251e-01 4 128074934 128074993 60 + 1.799 1.747 -0.176
ENSG00000138709 E015 74.5792853 0.0041257891 2.420614e-01 3.766276e-01 4 128077788 128077840 53 + 1.850 1.807 -0.145
ENSG00000138709 E016 120.5167713 0.0025113592 4.316350e-01 5.741701e-01 4 128077841 128077962 122 + 2.045 2.032 -0.042
ENSG00000138709 E017 135.0257413 0.0002826921 9.642384e-02 1.849937e-01 4 128082165 128082305 141 + 2.098 2.063 -0.118
ENSG00000138709 E018 145.3321729 0.0002953845 8.675949e-03 2.547410e-02 4 128091001 128091144 144 + 2.137 2.072 -0.220
ENSG00000138709 E019 110.4060242 0.0003253342 3.484368e-01 4.926743e-01 4 128091347 128091512 166 + 2.006 1.992 -0.047
ENSG00000138709 E020 117.5108432 0.0019359482 4.829124e-01 6.210208e-01 4 128098186 128098330 145 + 2.013 2.062 0.165
ENSG00000138709 E021 148.1276034 0.0005694542 2.836658e-01 4.238108e-01 4 128107139 128107313 175 + 2.112 2.168 0.187
ENSG00000138709 E022 25.6907654 0.0008346430 1.766896e-02 4.642424e-02 4 128107314 128107882 569 + 1.324 1.513 0.655
ENSG00000138709 E023 287.7670433 0.0037030942 1.947722e-15 7.090372e-14 4 128107883 128108901 1019 + 2.320 2.596 0.921
ENSG00000138709 E024 42.7766698 0.0010627026 1.677721e-05 1.058723e-04 4 128114570 128114742 173 + 1.659 1.393 -0.913
ENSG00000138709 E025 60.4225516 0.0009156085 1.377677e-01 2.449639e-01 4 128121826 128122116 291 + 1.761 1.705 -0.189
ENSG00000138709 E026 32.9706845 0.0013181491 4.512896e-01 5.922748e-01 4 128122117 128122188 72 + 1.497 1.466 -0.106
ENSG00000138709 E027 5.3133351 0.0031364528 6.823616e-01 7.858106e-01 4 128122189 128122352 164 + 0.783 0.741 -0.166
ENSG00000138709 E028 69.0166182 0.0006909068 5.817253e-03 1.813137e-02 4 128122482 128123869 1388 + 1.757 1.903 0.494
ENSG00000138709 E029 16.0634713 0.0011549509 3.457503e-02 8.085090e-02 4 128162194 128162317 124 + 1.239 1.048 -0.683
ENSG00000138709 E030 1.5166217 0.1838153062 6.423653e-01 7.551656e-01 4 128168818 128168845 28 + 0.328 0.437 0.624
ENSG00000138709 E031 0.2966881 0.0290785164 6.853737e-01   4 128174809 128174822 14 + 0.138 0.000 -11.261
ENSG00000138709 E032 2.8839221 0.0051016506 9.734239e-02 1.864181e-01 4 128176872 128176907 36 + 0.622 0.328 -1.498
ENSG00000138709 E033 1.4005953 0.0127854557 8.017676e-01 8.736984e-01 4 128177211 128177266 56 + 0.364 0.328 -0.217
ENSG00000138709 E034 11.8702923 0.0015151210 1.454475e-02 3.946518e-02 4 128178431 128178511 81 + 1.126 0.858 -0.995
ENSG00000138709 E035 20.9614869 0.0008977394 7.242282e-03 2.185385e-02 4 128178512 128178642 131 + 1.350 1.128 -0.783
ENSG00000138709 E036 0.0000000       4 128179314 128179346 33 +      
ENSG00000138709 E037 0.1515154 0.0423709633 1.000000e+00   4 128179347 128179405 59 + 0.075 0.000 -10.235
ENSG00000138709 E038 19.0007216 0.0009717167 1.694407e-01 2.874648e-01 4 128179406 128179512 107 + 1.283 1.180 -0.366
ENSG00000138709 E039 22.6407042 0.0009047998 5.403204e-01 6.714777e-01 4 128199439 128199599 161 + 1.335 1.305 -0.104
ENSG00000138709 E040 21.7503807 0.0135922437 1.969495e-01 3.224123e-01 4 128200521 128200665 145 + 1.339 1.228 -0.387
ENSG00000138709 E041 17.2298367 0.0062191003 9.811032e-02 1.876422e-01 4 128206428 128206537 110 + 1.257 1.109 -0.526
ENSG00000138709 E042 18.3671499 0.0063028995 8.098000e-01 8.792843e-01 4 128207256 128207383 128 + 1.243 1.240 -0.010
ENSG00000138709 E043 21.0192197 0.0012041205 1.269213e-01 2.298612e-01 4 128209856 128209993 138 + 1.324 1.211 -0.396
ENSG00000138709 E044 49.6900524 0.0050207065 2.124361e-01 3.414069e-01 4 128209994 128211988 1995 + 1.630 1.729 0.335
ENSG00000138709 E045 7.0481929 0.0023872896 6.517745e-01 7.625833e-01 4 128220355 128220440 86 + 0.845 0.921 0.290
ENSG00000138709 E046 13.6221688 0.0013601851 4.766768e-02 1.050266e-01 4 128222349 128222931 583 + 1.061 1.267 0.736