ENSG00000138696

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394931 ENSG00000138696 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPR1B protein_coding protein_coding 1.320074 0.5686442 2.665827 0.1061399 0.1500154 2.209236 0.05614047 0.00000000 0.2350735 0.00000000 0.23507354 4.6151428 0.02057083 0.0000000 0.07926667 0.07926667 1.0000000000 1.03779e-05 FALSE TRUE
ENST00000440890 ENSG00000138696 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPR1B protein_coding protein_coding 1.320074 0.5686442 2.665827 0.1061399 0.1500154 2.209236 0.07045030 0.17951072 0.0000000 0.08975642 0.00000000 -4.2442076 0.15447083 0.3881333 0.00000000 -0.38813333 0.0859372375 1.03779e-05 FALSE TRUE
ENST00000512312 ENSG00000138696 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPR1B protein_coding protein_coding 1.320074 0.5686442 2.665827 0.1061399 0.1500154 2.209236 0.35314918 0.00000000 0.8136259 0.00000000 0.03627961 6.3639174 0.18939583 0.0000000 0.30833333 0.30833333 0.0000103779 1.03779e-05 FALSE TRUE
ENST00000515059 ENSG00000138696 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPR1B protein_coding protein_coding 1.320074 0.5686442 2.665827 0.1061399 0.1500154 2.209236 0.56161499 0.09688853 1.0274273 0.09688853 0.20991438 3.2788313 0.40900000 0.1240667 0.39590000 0.27183333 0.3014441790 1.03779e-05 FALSE TRUE
MSTRG.25197.1 ENSG00000138696 HEK293_OSMI2_2hA HEK293_TMG_2hB BMPR1B protein_coding   1.320074 0.5686442 2.665827 0.1061399 0.1500154 2.209236 0.26029262 0.29224498 0.5897004 0.09900889 0.17563407 0.9885236 0.20364167 0.4878000 0.21650000 -0.27130000 0.0981399061 1.03779e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138696 E001 1.0632359 0.0121989077 6.189449e-01 7.364690e-01 4 94757913 94757954 42 + 0.310 0.207 -0.775
ENSG00000138696 E002 3.0883268 0.0329967424 7.553772e-01 8.407353e-01 4 94757955 94758068 114 + 0.557 0.607 0.225
ENSG00000138696 E003 4.8862361 0.0033929215 7.032646e-01 8.019667e-01 4 94875831 94875900 70 + 0.714 0.769 0.224
ENSG00000138696 E004 0.0000000       4 94974984 94975147 164 +      
ENSG00000138696 E005 0.0000000       4 94985641 94985712 72 +      
ENSG00000138696 E006 0.0000000       4 94995796 94995942 147 +      
ENSG00000138696 E007 0.0000000       4 94995943 94996039 97 +      
ENSG00000138696 E008 6.4436453 0.0079057386 9.118462e-01 9.480784e-01 4 94996040 94996134 95 + 0.828 0.811 -0.066
ENSG00000138696 E009 0.0000000       4 94996232 94996384 153 +      
ENSG00000138696 E010 0.3666179 0.0352446213 3.496900e-01 4.938942e-01 4 95051677 95051772 96 + 0.070 0.207 1.814
ENSG00000138696 E011 0.0000000       4 95091434 95091490 57 +      
ENSG00000138696 E012 0.0000000       4 95091491 95091627 137 +      
ENSG00000138696 E013 0.3289534 0.0303338181 3.506702e-01   4 95104355 95104407 53 + 0.070 0.207 1.811
ENSG00000138696 E014 8.8159924 0.0023683544 1.057490e-01 1.992345e-01 4 95104408 95104567 160 + 0.986 0.769 -0.834
ENSG00000138696 E015 8.9038175 0.0523973498 5.267224e-01 6.599166e-01 4 95114720 95114822 103 + 0.971 0.850 -0.459
ENSG00000138696 E016 0.1451727 0.0444051497 1.000000e+00   4 95114823 95114827 5 + 0.070 0.000 -7.551
ENSG00000138696 E017 9.8396012 0.0018784564 8.814740e-02 1.723030e-01 4 95115685 95115787 103 + 1.031 0.812 -0.828
ENSG00000138696 E018 9.1959757 0.0018797800 1.437738e-01 2.531466e-01 4 95123810 95123906 97 + 1.002 0.812 -0.721
ENSG00000138696 E019 14.3152131 0.0036118401 3.379735e-03 1.137812e-02 4 95124983 95125121 139 + 1.198 0.851 -1.278
ENSG00000138696 E020 17.1885355 0.0112519922 8.581039e-02 1.686900e-01 4 95129862 95130054 193 + 1.247 1.055 -0.688
ENSG00000138696 E021 19.1107724 0.0308021680 8.703658e-01 9.206127e-01 4 95131215 95131512 298 + 1.259 1.236 -0.081
ENSG00000138696 E022 15.6079168 0.0012896683 9.168198e-01 9.514534e-01 4 95148748 95148923 176 + 1.168 1.176 0.029
ENSG00000138696 E023 14.7839975 0.0014609294 7.583327e-01 8.429740e-01 4 95152643 95152773 131 + 1.153 1.120 -0.116
ENSG00000138696 E024 15.3083994 0.0015182570 9.759124e-01 9.889866e-01 4 95154548 95154686 139 + 1.163 1.158 -0.017
ENSG00000138696 E025 41.8450373 0.0017050033 5.638303e-01 6.912393e-01 4 95154687 95156786 2100 + 1.584 1.546 -0.131
ENSG00000138696 E026 45.9667620 0.0008055284 3.449604e-09 4.628636e-08 4 95156787 95158448 1662 + 1.530 1.816 0.973