ENSG00000138678

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264409 ENSG00000138678 HEK293_OSMI2_2hA HEK293_TMG_2hB GPAT3 protein_coding protein_coding 2.804485 2.304983 3.701887 0.08914263 0.1727499 0.6811509 0.5194231 0.2281643 1.0156093 0.05684396 0.01441576 2.106452 0.16517083 0.1011000 0.27590000 0.17480000 0.004832986 0.004832986 FALSE TRUE
ENST00000395226 ENSG00000138678 HEK293_OSMI2_2hA HEK293_TMG_2hB GPAT3 protein_coding protein_coding 2.804485 2.304983 3.701887 0.08914263 0.1727499 0.6811509 0.3805034 0.3888450 0.1123568 0.38884497 0.11235676 -1.704734 0.12557500 0.1649000 0.03343333 -0.13146667 0.953092472 0.004832986 FALSE TRUE
ENST00000506766 ENSG00000138678 HEK293_OSMI2_2hA HEK293_TMG_2hB GPAT3 protein_coding processed_transcript 2.804485 2.304983 3.701887 0.08914263 0.1727499 0.6811509 0.1288184 0.0000000 0.2391075 0.00000000 0.12495083 4.638697 0.04060417 0.0000000 0.06163333 0.06163333 0.246822050 0.004832986 FALSE FALSE
ENST00000509044 ENSG00000138678 HEK293_OSMI2_2hA HEK293_TMG_2hB GPAT3 protein_coding processed_transcript 2.804485 2.304983 3.701887 0.08914263 0.1727499 0.6811509 0.1213245 0.4836540 0.0000000 0.24665227 0.00000000 -5.625428 0.05974167 0.2026000 0.00000000 -0.20260000 0.127577704 0.004832986   FALSE
MSTRG.24990.1 ENSG00000138678 HEK293_OSMI2_2hA HEK293_TMG_2hB GPAT3 protein_coding   2.804485 2.304983 3.701887 0.08914263 0.1727499 0.6811509 1.5476197 1.0239536 2.3348131 0.53287076 0.17657250 1.181302 0.56016667 0.4561333 0.62906667 0.17293333 0.842891531 0.004832986 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138678 E001 0.4720498 0.194149459 9.361329e-01 9.638245e-01 4 83535859 83535889 31 + 0.175 0.154 -0.223
ENSG00000138678 E002 0.3332198 0.029734290 7.187097e-01   4 83535914 83535974 61 + 0.097 0.154 0.771
ENSG00000138678 E003 0.6299079 0.024635730 5.938039e-01 7.161142e-01 4 83535975 83536017 43 + 0.242 0.154 -0.814
ENSG00000138678 E004 1.0373134 0.011850472 1.941341e-02 5.023081e-02 4 83536018 83536107 90 + 0.438 0.001 -10.386
ENSG00000138678 E005 2.3207599 0.006789389 7.116150e-01 8.085436e-01 4 83536108 83536206 99 + 0.543 0.495 -0.230
ENSG00000138678 E006 2.1422647 0.006858358 1.874591e-01 3.105377e-01 4 83536207 83536306 100 + 0.573 0.357 -1.104
ENSG00000138678 E007 1.5575230 0.008641028 4.700401e-02 1.038336e-01 4 83536307 83536314 8 + 0.511 0.154 -2.399
ENSG00000138678 E008 3.1785314 0.004928197 2.228645e-01 3.537876e-01 4 83536315 83536355 41 + 0.676 0.495 -0.814
ENSG00000138678 E009 3.9254993 0.004291530 5.465828e-02 1.174019e-01 4 83536356 83536410 55 + 0.777 0.495 -1.229
ENSG00000138678 E010 4.9435941 0.003397315 2.446680e-01 3.796549e-01 4 83536411 83536503 93 + 0.828 0.683 -0.584
ENSG00000138678 E011 4.1277521 0.009371126 9.572080e-01 9.771890e-01 4 83536504 83536505 2 + 0.698 0.720 0.092
ENSG00000138678 E012 19.9672413 0.001101318 3.007296e-02 7.209678e-02 4 83536506 83536763 258 + 1.374 1.223 -0.528
ENSG00000138678 E013 17.0366327 0.001150300 5.758563e-02 1.224773e-01 4 83544536 83544602 67 + 1.305 1.164 -0.497
ENSG00000138678 E014 0.0000000       4 83544603 83544613 11 +      
ENSG00000138678 E015 31.2895878 0.001973535 3.643524e-02 8.441107e-02 4 83581562 83581832 271 + 1.546 1.430 -0.396
ENSG00000138678 E016 16.7072072 0.029790977 4.818127e-01 6.200106e-01 4 83587255 83587329 75 + 1.265 1.202 -0.223
ENSG00000138678 E017 13.2726200 0.042951584 7.956033e-01 8.694817e-01 4 83588210 83588257 48 + 1.128 1.168 0.145
ENSG00000138678 E018 13.1619172 0.019924020 8.225830e-01 8.881460e-01 4 83588258 83588299 42 + 1.128 1.165 0.132
ENSG00000138678 E019 17.7309549 0.001088095 3.706032e-01 5.150206e-01 4 83590199 83590292 94 + 1.289 1.234 -0.191
ENSG00000138678 E020 21.0947541 0.003050375 1.920520e-01 3.163221e-01 4 83594845 83594960 116 + 1.370 1.285 -0.294
ENSG00000138678 E021 0.0000000       4 83594961 83595335 375 +      
ENSG00000138678 E022 18.1561879 0.011680630 9.269726e-01 9.580432e-01 4 83596858 83596913 56 + 1.271 1.277 0.018
ENSG00000138678 E023 21.5124463 0.001440740 8.416635e-01 9.012329e-01 4 83597430 83597515 86 + 1.331 1.364 0.113
ENSG00000138678 E024 24.8427367 0.010251291 9.092346e-01 9.463447e-01 4 83598051 83598179 129 + 1.405 1.414 0.031
ENSG00000138678 E025 0.0000000       4 83598529 83598643 115 +      
ENSG00000138678 E026 24.5383681 0.007057190 3.499887e-01 4.941667e-01 4 83598644 83598723 80 + 1.365 1.455 0.311
ENSG00000138678 E027 95.9875508 0.006112123 6.531674e-06 4.529304e-05 4 83604668 83605875 1208 + 1.883 2.089 0.694