ENSG00000138670

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264400 ENSG00000138670 HEK293_OSMI2_2hA HEK293_TMG_2hB RASGEF1B protein_coding protein_coding 3.135616 1.799443 4.79371 0.2449953 0.2171555 1.408604 1.67394304 1.02383194 2.2390899 0.09354789 0.2086499 1.121340 0.53687500 0.58426667 0.4682333 -0.11603333 5.546321e-01 6.123158e-07 FALSE TRUE
ENST00000335927 ENSG00000138670 HEK293_OSMI2_2hA HEK293_TMG_2hB RASGEF1B protein_coding protein_coding 3.135616 1.799443 4.79371 0.2449953 0.2171555 1.408604 0.27442657 0.03298365 0.5515136 0.03298365 0.1572595 3.707461 0.06537083 0.01493333 0.1124667 0.09753333 5.631712e-02 6.123158e-07 FALSE TRUE
ENST00000507538 ENSG00000138670 HEK293_OSMI2_2hA HEK293_TMG_2hB RASGEF1B protein_coding retained_intron 3.135616 1.799443 4.79371 0.2449953 0.2171555 1.408604 0.08739048 0.00000000 0.2702458 0.00000000 0.1189184 4.808621 0.01737917 0.00000000 0.0564000 0.05640000 3.984571e-02 6.123158e-07   FALSE
ENST00000509081 ENSG00000138670 HEK293_OSMI2_2hA HEK293_TMG_2hB RASGEF1B protein_coding protein_coding 3.135616 1.799443 4.79371 0.2449953 0.2171555 1.408604 0.08377282 0.11992947 0.0000000 0.06675429 0.0000000 -3.699657 0.07005000 0.06636667 0.0000000 -0.06636667 6.392976e-02 6.123158e-07 FALSE TRUE
ENST00000510780 ENSG00000138670 HEK293_OSMI2_2hA HEK293_TMG_2hB RASGEF1B protein_coding processed_transcript 3.135616 1.799443 4.79371 0.2449953 0.2171555 1.408604 0.03258227 0.14811023 0.0000000 0.03645870 0.0000000 -3.982859 0.01325417 0.08130000 0.0000000 -0.08130000 4.209640e-06 6.123158e-07 TRUE FALSE
ENST00000514050 ENSG00000138670 HEK293_OSMI2_2hA HEK293_TMG_2hB RASGEF1B protein_coding protein_coding 3.135616 1.799443 4.79371 0.2449953 0.2171555 1.408604 0.10950757 0.26038780 0.1248169 0.05924220 0.1248169 -1.004029 0.06649167 0.15163333 0.0286000 -0.12303333 1.416242e-01 6.123158e-07 FALSE FALSE
MSTRG.25068.4 ENSG00000138670 HEK293_OSMI2_2hA HEK293_TMG_2hB RASGEF1B protein_coding   3.135616 1.799443 4.79371 0.2449953 0.2171555 1.408604 0.66762449 0.00000000 1.1078950 0.00000000 0.2055348 6.804641 0.15659167 0.00000000 0.2324333 0.23243333 6.123158e-07 6.123158e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138670 E001 30.8293540 0.0094137488 0.0001649542 0.0008133803 4 81426393 81427064 672 - 1.363 1.646 0.971
ENSG00000138670 E002 29.1512536 0.0128475777 0.0072847443 0.0219630938 4 81427065 81427448 384 - 1.367 1.587 0.755
ENSG00000138670 E003 34.4018783 0.0015375858 0.2163211786 0.3459776475 4 81427449 81427792 344 - 1.494 1.580 0.295
ENSG00000138670 E004 13.3514898 0.0017981171 0.1125430562 0.2092606943 4 81432299 81432371 73 - 1.170 1.017 -0.552
ENSG00000138670 E005 17.1712520 0.0012031437 0.6237159974 0.7402326960 4 81433840 81433963 124 - 1.241 1.208 -0.117
ENSG00000138670 E006 11.9877802 0.0261512326 0.2004685392 0.3267940873 4 81434639 81434675 37 - 1.133 0.969 -0.598
ENSG00000138670 E007 11.3871057 0.0185159264 0.0606790019 0.1277727066 4 81434676 81434734 59 - 1.126 0.891 -0.867
ENSG00000138670 E008 17.0854901 0.0014160284 0.3557026462 0.5000532482 4 81440834 81440929 96 - 1.251 1.179 -0.255
ENSG00000138670 E009 16.6832840 0.0011899684 0.3006468235 0.4423804452 4 81442297 81442376 80 - 1.246 1.164 -0.292
ENSG00000138670 E010 17.9375883 0.0011176858 0.2627559490 0.4005626917 4 81445526 81445628 103 - 1.280 1.194 -0.304
ENSG00000138670 E011 16.4086465 0.0063815473 0.1742466968 0.2937087512 4 81445743 81445838 96 - 1.251 1.131 -0.429
ENSG00000138670 E012 14.2411126 0.0013451875 0.0743253374 0.1504671105 4 81447504 81447578 75 - 1.204 1.038 -0.597
ENSG00000138670 E013 22.3913874 0.0008983226 0.4509325737 0.5919497719 4 81448069 81448281 213 - 1.356 1.308 -0.167
ENSG00000138670 E014 3.1922741 0.0088701380 0.8745066483 0.9233072977 4 81448282 81448284 3 - 0.584 0.617 0.143
ENSG00000138670 E015 1.5552563 0.0093331535 0.1580141024 0.2724883502 4 81450893 81452028 1136 - 0.304 0.557 1.363
ENSG00000138670 E016 0.4449813 0.0211894880 0.8514230229 0.9078705080 4 81452029 81452434 406 - 0.148 0.182 0.364
ENSG00000138670 E017 1.3767622 0.1896241905 0.3080248691 0.4502568900 4 81452435 81456650 4216 - 0.419 0.183 -1.636
ENSG00000138670 E018 19.1524901 0.0011056418 0.5033922882 0.6393590653 4 81456651 81456788 138 - 1.293 1.248 -0.159
ENSG00000138670 E019 16.4152874 0.0012459074 0.3584494491 0.5028559257 4 81457499 81457621 123 - 1.236 1.164 -0.256
ENSG00000138670 E020 1.1718769 0.0617014570 0.0514125463 0.1116646908 4 81458983 81459331 349 - 0.418 0.000 -12.610
ENSG00000138670 E021 18.1672169 0.0338375226 0.0222154264 0.0561212649 4 81459332 81459478 147 - 1.323 1.042 -1.001
ENSG00000138670 E022 8.9619453 0.0021397120 0.0021894591 0.0078090680 4 81459479 81459514 36 - 1.062 0.668 -1.527
ENSG00000138670 E023 0.3686942 0.0414008179 0.4976270123 0.6341666416 4 81471021 81471236 216 - 0.080 0.183 1.370
ENSG00000138670 E024 8.1889410 0.0025382719 0.0020946032 0.0075173110 4 81471770 81471928 159 - 1.031 0.616 -1.634
ENSG00000138670 E025 0.0000000       4 81521412 81521545 134 -      
ENSG00000138670 E026 1.3650165 0.0109982278 0.0005524634 0.0023559908 4 81602732 81602838 107 - 0.080 0.668 4.172
ENSG00000138670 E027 1.5154878 0.0101306803 0.0190779215 0.0495096641 4 81602839 81602870 32 - 0.206 0.616 2.365
ENSG00000138670 E028 1.2156792 0.0238087258 0.0216057558 0.0548605497 4 81602871 81602873 3 - 0.148 0.558 2.689
ENSG00000138670 E029 1.7337108 0.0514618892 0.0016995021 0.0062820098 4 81602874 81602922 49 - 0.148 0.714 3.365
ENSG00000138670 E030 0.9693556 0.1466212442 0.0919788315 0.1781964053 4 81635798 81635822 25 - 0.148 0.486 2.344
ENSG00000138670 E031 1.9249947 0.0074186472 0.0332765248 0.0783390057 4 81635823 81635897 75 - 0.304 0.668 1.849
ENSG00000138670 E032 0.2903454 0.3481957650 0.7182325600   4 81802807 81802889 83 - 0.147 0.000 -10.607
ENSG00000138670 E033 3.3494598 0.0087315623 0.0009290186 0.0037158442 4 81824518 81824571 54 - 0.384 0.892 2.258
ENSG00000138670 E034 0.8814403 0.0140666953 0.0007985021 0.0032541102 4 81894581 81894624 44 - 0.000 0.558 14.389
ENSG00000138670 E035 3.2440305 0.0619463634 0.0897383181 0.1747312855 4 81915311 81915358 48 - 0.481 0.793 1.362
ENSG00000138670 E036 2.6152685 0.0377117592 0.0972231328 0.1862367753 4 82044001 82044244 244 - 0.419 0.714 1.366