ENSG00000138668

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000352301 ENSG00000138668 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPD protein_coding protein_coding 580.5872 798.477 585.9239 12.37032 25.27549 -0.4465311 61.97945 74.1071 64.82747 6.304095 1.149792 -0.1929787 0.10813750 0.09283333 0.11123333 0.0184000 4.680286e-01 4.69174e-189 FALSE TRUE
ENST00000353341 ENSG00000138668 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPD protein_coding protein_coding 580.5872 798.477 585.9239 12.37032 25.27549 -0.4465311 225.70100 356.5917 188.12244 8.934399 5.491423 -0.9225651 0.38185000 0.44683333 0.32150000 -0.1253333 1.222166e-07 4.69174e-189 FALSE TRUE
ENST00000507010 ENSG00000138668 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPD protein_coding protein_coding 580.5872 798.477 585.9239 12.37032 25.27549 -0.4465311 26.58429 0.0000 78.56145 0.000000 2.683550 12.9397895 0.04808333 0.00000000 0.13436667 0.1343667 4.691740e-189 4.69174e-189 FALSE FALSE
ENST00000509263 ENSG00000138668 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPD protein_coding protein_coding 580.5872 798.477 585.9239 12.37032 25.27549 -0.4465311 143.75578 163.5792 154.47888 5.533890 12.928785 -0.0825743 0.25703750 0.20500000 0.26270000 0.0577000 2.476334e-02 4.69174e-189 FALSE FALSE
MSTRG.25007.12 ENSG00000138668 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPD protein_coding   580.5872 798.477 585.9239 12.37032 25.27549 -0.4465311 79.17421 164.2745 50.54090 22.954138 5.255832 -1.7003880 0.12450833 0.20533333 0.08583333 -0.1195000 1.082303e-04 4.69174e-189 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138668 E001 138.741388 0.0057775800 6.759792e-06 4.672269e-05 4 82352498 82353075 578 - 2.236 2.055 -0.608
ENSG00000138668 E002 91.729054 0.0090241414 2.708023e-10 4.437182e-09 4 82353076 82353332 257 - 2.140 1.799 -1.144
ENSG00000138668 E003 153.678025 0.0007860909 4.646573e-03 1.494989e-02 4 82353333 82353455 123 - 2.207 2.148 -0.199
ENSG00000138668 E004 264.340774 0.0001693389 1.343057e-01 2.401357e-01 4 82353456 82353648 193 - 2.404 2.400 -0.014
ENSG00000138668 E005 137.685877 0.0004246170 2.570073e-04 1.204484e-03 4 82353649 82353665 17 - 2.172 2.085 -0.291
ENSG00000138668 E006 152.512965 0.0008380332 3.916133e-02 8.948077e-02 4 82353666 82353710 45 - 2.186 2.149 -0.123
ENSG00000138668 E007 98.772370 0.0004310285 7.702414e-02 1.547253e-01 4 82353711 82353715 5 - 1.997 1.961 -0.123
ENSG00000138668 E008 156.065683 0.0002616998 1.964890e-05 1.221268e-04 4 82353716 82353741 26 - 2.232 2.136 -0.322
ENSG00000138668 E009 133.438999 0.0002401853 1.756663e-06 1.383531e-05 4 82353742 82353750 9 - 2.181 2.060 -0.405
ENSG00000138668 E010 194.712940 0.0002088021 1.647338e-09 2.345432e-08 4 82353751 82353828 78 - 2.348 2.218 -0.431
ENSG00000138668 E011 135.681669 0.0022554326 5.901994e-01 7.131121e-01 4 82353829 82353833 5 - 2.080 2.133 0.178
ENSG00000138668 E012 5559.244987 0.0008695174 2.757733e-34 6.449928e-32 4 82353834 82354154 321 - 3.573 3.781 0.691
ENSG00000138668 E013 309.197185 0.0096339227 2.150855e-36 5.763410e-34 4 82354155 82354846 692 - 2.780 2.139 -2.137
ENSG00000138668 E014 80.855332 0.0040780502 1.401807e-38 4.426137e-36 4 82354847 82354894 48 - 2.198 1.569 -2.120
ENSG00000138668 E015 186.499489 0.0003238662 8.084098e-100 2.430965e-96 4 82354895 82355001 107 - 2.530 1.983 -1.828
ENSG00000138668 E016 132.748291 0.0015279967 1.206255e-134 9.140855e-131 4 82355002 82355248 247 - 2.486 1.546 -3.161
ENSG00000138668 E017 54.138302 0.0066308711 3.938386e-14 1.185816e-12 4 82355249 82355303 55 - 1.956 1.514 -1.496
ENSG00000138668 E018 4857.744462 0.0011167887 2.272021e-20 1.513458e-18 4 82355304 82355401 98 - 3.533 3.716 0.608
ENSG00000138668 E019 28.987264 0.0128575132 9.689336e-16 3.665367e-14 4 82355402 82356536 1135 - 1.769 1.099 -2.321
ENSG00000138668 E020 1102.231942 0.0025666015 1.413433e-02 3.852980e-02 4 82356537 82356553 17 - 2.951 3.050 0.329
ENSG00000138668 E021 2474.442528 0.0034501252 4.616561e-01 6.015719e-01 4 82356554 82356683 130 - 3.333 3.387 0.178
ENSG00000138668 E022 11.595838 0.1012904533 5.441576e-01 6.746753e-01 4 82356684 82356795 112 - 1.131 1.060 -0.255
ENSG00000138668 E023 5648.143817 0.0009727893 3.001097e-05 1.785980e-04 4 82356796 82356895 100 - 3.664 3.757 0.310
ENSG00000138668 E024 4747.608884 0.0003575988 4.221871e-02 9.512503e-02 4 82357313 82357402 90 - 3.619 3.669 0.166
ENSG00000138668 E025 3242.901098 0.0007341174 1.752992e-02 4.610438e-02 4 82357403 82357436 34 - 3.444 3.507 0.209
ENSG00000138668 E026 2389.561559 0.0017548985 2.523054e-02 6.234966e-02 4 82357437 82357444 8 - 3.303 3.378 0.252
ENSG00000138668 E027 24.778381 0.0042811923 1.187716e-03 4.599816e-03 4 82357445 82358658 1214 - 1.518 1.304 -0.741
ENSG00000138668 E028 4955.708771 0.0011150955 2.644268e-02 6.483430e-02 4 82358659 82358757 99 - 3.627 3.691 0.213
ENSG00000138668 E029 4370.578455 0.0002961150 3.841751e-01 5.283467e-01 4 82358758 82358820 63 - 3.591 3.628 0.125
ENSG00000138668 E030 12.485088 0.0595992958 6.599818e-01 7.686999e-01 4 82358821 82358842 22 - 1.041 1.142 0.368
ENSG00000138668 E031 3848.305768 0.0003087642 5.886055e-06 4.124783e-05 4 82359471 82359515 45 - 3.572 3.555 -0.055
ENSG00000138668 E032 5819.746628 0.0001075443 1.069689e-14 3.501804e-13 4 82359516 82359639 124 - 3.755 3.734 -0.069
ENSG00000138668 E033 2940.587740 0.0001362793 7.465398e-22 5.844203e-20 4 82371528 82371584 57 - 3.478 3.426 -0.174
ENSG00000138668 E034 5.902322 0.0039772634 1.527824e-01 2.654455e-01 4 82373119 82373150 32 - 0.906 0.748 -0.618
ENSG00000138668 E035 2601.392095 0.0004417103 3.798511e-15 1.331144e-13 4 82373446 82373486 41 - 3.434 3.367 -0.222
ENSG00000138668 E036 1509.512558 0.0092236489 1.103963e-06 9.082491e-06 4 82373487 82373624 138 - 3.278 3.075 -0.674
ENSG00000138668 E037 1685.355697 0.0071135672 1.926868e-03 6.998990e-03 4 82373625 82373737 113 - 3.265 3.166 -0.330
ENSG00000138668 E038 1755.687503 0.0060745808 1.729321e-01 2.920048e-01 4 82373738 82373777 40 - 3.234 3.212 -0.073
ENSG00000138668 E039 2104.812724 0.0078233006 2.394869e-01 3.735208e-01 4 82373778 82374063 286 - 3.312 3.292 -0.066
ENSG00000138668 E040 53.043140 0.0039680368 1.640605e-06 1.300205e-05 4 82374119 82374155 37 - 1.855 1.615 -0.812
ENSG00000138668 E041 6.018235 0.0713505028 4.200185e-01 5.632613e-01 4 82374156 82374297 142 - 0.883 0.787 -0.372
ENSG00000138668 E042 2.849398 0.0057274327 9.243097e-01 9.563208e-01 4 82374298 82375206 909 - 0.543 0.580 0.172