ENSG00000138660

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274000 ENSG00000138660 HEK293_OSMI2_2hA HEK293_TMG_2hB AP1AR protein_coding protein_coding 15.49457 3.044038 28.56392 0.1104615 0.7454731 3.225909 4.379410 1.6697185 8.551228 0.20688037 0.5178876 2.349598 0.4020833 0.5510 0.2993000 -0.2517000 0.01231358 0.01231358 FALSE TRUE
ENST00000510527 ENSG00000138660 HEK293_OSMI2_2hA HEK293_TMG_2hB AP1AR protein_coding retained_intron 15.49457 3.044038 28.56392 0.1104615 0.7454731 3.225909 3.867243 0.4132593 6.965714 0.09115473 0.4358896 4.042727 0.2228583 0.1362 0.2435333 0.1073333 0.05161398 0.01231358 FALSE TRUE
ENST00000512741 ENSG00000138660 HEK293_OSMI2_2hA HEK293_TMG_2hB AP1AR protein_coding protein_coding 15.49457 3.044038 28.56392 0.1104615 0.7454731 3.225909 6.166464 0.7201706 11.427221 0.37111994 0.3236273 3.969359 0.3111792 0.2287 0.4002667 0.1715667 0.62178637 0.01231358   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138660 E001 9.4135464 0.0134593770 5.797316e-01 7.045658e-01 4 112231740 112231786 47 + 0.840 1.012 0.648
ENSG00000138660 E002 30.4062876 0.0091501697 6.149703e-01 7.333610e-01 4 112231787 112231808 22 + 1.321 1.369 0.167
ENSG00000138660 E003 36.7088765 0.0136916557 8.839682e-01 9.298026e-01 4 112231809 112231824 16 + 1.395 1.477 0.283
ENSG00000138660 E004 38.8960814 0.0063510520 7.089095e-01 8.064418e-01 4 112231825 112231832 8 + 1.422 1.489 0.231
ENSG00000138660 E005 55.4706073 0.0004640068 2.555768e-01 3.924797e-01 4 112231833 112231888 56 + 1.577 1.603 0.088
ENSG00000138660 E006 110.1185297 0.0010994045 2.808090e-03 9.698714e-03 4 112231889 112232174 286 + 1.878 1.827 -0.173
ENSG00000138660 E007 0.4386386 0.1335822691 3.600858e-01 5.044008e-01 4 112232291 112232372 82 + 0.089 0.284 2.022
ENSG00000138660 E008 42.3470127 0.0098242732 1.819339e-01 3.036397e-01 4 112253208 112253256 49 + 1.469 1.448 -0.073
ENSG00000138660 E009 0.6611159 0.0307439442 5.182113e-01 6.524766e-01 4 112253257 112253311 55 + 0.128 0.286 1.450
ENSG00000138660 E010 42.2324023 0.0034593036 1.551762e-02 4.166827e-02 4 112254747 112254773 27 + 1.478 1.368 -0.378
ENSG00000138660 E011 0.4460135 0.0423792352 1.000000e+00 1.000000e+00 4 112254774 112254894 121 + 0.128 0.000 -9.505
ENSG00000138660 E012 54.5365001 0.0005148926 6.335790e-02 1.322874e-01 4 112257772 112257797 26 + 1.577 1.549 -0.095
ENSG00000138660 E013 3.6159009 0.1013249908 5.255166e-01 6.588721e-01 4 112258333 112258479 147 + 0.544 0.457 -0.425
ENSG00000138660 E014 80.3102421 0.0003434260 8.604442e-03 2.529932e-02 4 112260766 112260862 97 + 1.744 1.694 -0.172
ENSG00000138660 E015 82.8558186 0.0018565546 5.621922e-02 1.200916e-01 4 112262988 112263086 99 + 1.752 1.740 -0.040
ENSG00000138660 E016 48.8077087 0.0179098864 7.610118e-02 1.532677e-01 4 112265009 112265012 4 + 1.537 1.449 -0.303
ENSG00000138660 E017 70.8096096 0.0091378337 3.537491e-02 8.237260e-02 4 112265013 112265051 39 + 1.692 1.624 -0.231
ENSG00000138660 E018 64.8444887 0.0054311169 2.896422e-02 6.993875e-02 4 112265052 112265067 16 + 1.654 1.593 -0.208
ENSG00000138660 E019 5.8321524 0.0262447215 3.196632e-01 4.627625e-01 4 112265068 112265319 252 + 0.698 0.580 -0.509
ENSG00000138660 E020 111.9617317 0.0002954672 9.219134e-04 3.691687e-03 4 112265734 112265807 74 + 1.888 1.826 -0.207
ENSG00000138660 E021 172.9433878 0.0002744204 8.292197e-05 4.418812e-04 4 112266588 112266716 129 + 2.074 2.022 -0.173
ENSG00000138660 E022 0.9889485 0.1268918731 4.842204e-04 2.099755e-03 4 112266717 112266830 114 + 0.047 0.749 5.341
ENSG00000138660 E023 636.9848063 0.0124128886 1.287968e-06 1.044617e-05 4 112268144 112273110 4967 + 2.584 2.862 0.925