ENSG00000138650

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264360 ENSG00000138650 HEK293_OSMI2_2hA HEK293_TMG_2hB PCDH10 protein_coding protein_coding 6.144597 7.818316 5.041634 0.3948591 0.2680089 -0.631952 1.1015538 1.7239583 1.29123819 0.19749716 0.006488397 -0.4141841 0.19881667 0.22373333 0.257766667 0.03403333 0.753380258 0.002099087 FALSE TRUE
ENST00000618019 ENSG00000138650 HEK293_OSMI2_2hA HEK293_TMG_2hB PCDH10 protein_coding protein_coding 6.144597 7.818316 5.041634 0.3948591 0.2680089 -0.631952 1.9046835 2.8645731 1.48717842 0.08601805 0.082717571 -0.9411016 0.29855000 0.36846667 0.295900000 -0.07256667 0.382865307 0.002099087 FALSE TRUE
MSTRG.25456.1 ENSG00000138650 HEK293_OSMI2_2hA HEK293_TMG_2hB PCDH10 protein_coding   6.144597 7.818316 5.041634 0.3948591 0.2680089 -0.631952 2.4240622 1.9508894 2.18563770 0.11122528 0.208260794 0.1631318 0.40785417 0.25166667 0.431466667 0.17980000 0.002099087 0.002099087 FALSE TRUE
MSTRG.25456.3 ENSG00000138650 HEK293_OSMI2_2hA HEK293_TMG_2hB PCDH10 protein_coding   6.144597 7.818316 5.041634 0.3948591 0.2680089 -0.631952 0.2875374 0.9164697 0.05860109 0.46341065 0.058601094 -3.7554403 0.04004583 0.11153333 0.011266667 -0.10026667 0.464338302 0.002099087 FALSE TRUE
MSTRG.25456.4 ENSG00000138650 HEK293_OSMI2_2hA HEK293_TMG_2hB PCDH10 protein_coding   6.144597 7.818316 5.041634 0.3948591 0.2680089 -0.631952 0.4063592 0.3624255 0.01897811 0.36242552 0.018978109 -3.6839166 0.05126667 0.04453333 0.003633333 -0.04090000 0.969034142 0.002099087 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138650 E001 0.1472490 0.0444866530 3.046081e-01   4 133149152 133149293 142 + 0.152 0.000 -9.185
ENSG00000138650 E002 1.2137046 0.0121761701 3.100181e-01 4.523890e-01 4 133149294 133149301 8 + 0.428 0.245 -1.150
ENSG00000138650 E003 4.8266318 0.0057235701 2.795760e-02 6.793204e-02 4 133149302 133149307 6 + 0.911 0.605 -1.238
ENSG00000138650 E004 12.1285486 0.0015258024 1.064496e-05 7.030106e-05 4 133149308 133149310 3 + 1.326 0.906 -1.516
ENSG00000138650 E005 20.6642227 0.0009493065 2.078757e-05 1.284400e-04 4 133149311 133149314 4 + 1.495 1.172 -1.126
ENSG00000138650 E006 40.8902336 0.0064512141 3.162385e-02 7.512281e-02 4 133149315 133149368 54 + 1.689 1.541 -0.504
ENSG00000138650 E007 259.2030697 0.0028437215 2.638584e-06 1.999727e-05 4 133149369 133150921 1553 + 2.479 2.335 -0.479
ENSG00000138650 E008 367.1579712 0.0002661475 6.581820e-01 7.673787e-01 4 133150922 133152771 1850 + 2.538 2.539 0.004
ENSG00000138650 E009 85.3978563 0.0003810111 1.432364e-08 1.715170e-07 4 133152772 133153888 1117 + 1.742 1.973 0.778
ENSG00000138650 E010 55.9074824 0.0004290721 9.416811e-01 9.673411e-01 4 133154307 133154365 59 + 1.732 1.730 -0.008
ENSG00000138650 E011 0.4772466 0.0207700723 8.866874e-01 9.315310e-01 4 133154893 133154916 24 + 0.152 0.177 0.260
ENSG00000138650 E012 73.7065460 0.0028923092 2.624097e-01 4.001926e-01 4 133154917 133155023 107 + 1.818 1.868 0.168
ENSG00000138650 E013 130.5585039 0.0011881696 9.269378e-04 3.709291e-03 4 133162977 133163282 306 + 2.020 2.130 0.368
ENSG00000138650 E014 200.1878814 0.0053682931 7.781712e-02 1.559726e-01 4 133190141 133194700 4560 + 2.234 2.300 0.223
ENSG00000138650 E015 14.3018614 0.0123390605 4.522685e-03 1.460678e-02 4 133208076 133208606 531 + 0.933 1.245 1.133