ENSG00000138646

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264350 ENSG00000138646 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC5 protein_coding protein_coding 5.790604 5.115449 6.943702 0.4955704 0.4016708 0.4401026 4.371141 2.398383 6.5050995 0.3995733 0.1668950 1.435722 0.7301792 0.4638667 0.9411 0.4772333 0.006511215 0.006511215 FALSE TRUE
ENST00000508159 ENSG00000138646 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC5 protein_coding protein_coding 5.790604 5.115449 6.943702 0.4955704 0.4016708 0.4401026 1.285041 2.549870 0.3192369 0.2501251 0.3192369 -2.958872 0.2407250 0.5003667 0.0418 -0.4585667 0.016653456 0.006511215 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138646 E001 20.1690747 0.0009859355 9.587367e-07 7.984078e-06 4 88457119 88457534 416 + 1.458 1.070 -1.367
ENSG00000138646 E002 0.1482932 0.0419255779 3.433260e-01   4 88457893 88458105 213 + 0.000 0.145 10.885
ENSG00000138646 E003 22.0146658 0.0010171306 1.913125e-02 4.962631e-02 4 88459347 88459470 124 + 1.420 1.258 -0.564
ENSG00000138646 E004 23.2134179 0.0260232995 2.405636e-01 3.748267e-01 4 88460095 88460171 77 + 1.420 1.317 -0.355
ENSG00000138646 E005 45.6159228 0.0020425990 2.862070e-03 9.859092e-03 4 88462135 88462356 222 + 1.724 1.571 -0.518
ENSG00000138646 E006 31.2489326 0.0007875815 5.145235e-04 2.213701e-03 4 88463532 88463623 92 + 1.589 1.381 -0.713
ENSG00000138646 E007 41.4442079 0.0005530880 1.911223e-03 6.950825e-03 4 88463855 88463985 131 + 1.692 1.536 -0.529
ENSG00000138646 E008 53.7074346 0.0004916634 6.096314e-04 2.568220e-03 4 88467059 88467204 146 + 1.798 1.647 -0.511
ENSG00000138646 E009 0.1482932 0.0419255779 3.433260e-01   4 88467856 88467936 81 + 0.000 0.145 10.885
ENSG00000138646 E010 42.0856406 0.0008259877 1.218725e-03 4.703756e-03 4 88468346 88468422 77 + 1.697 1.532 -0.561
ENSG00000138646 E011 40.6616064 0.0097451096 2.571594e-01 3.942086e-01 4 88469157 88469260 104 + 1.645 1.581 -0.218
ENSG00000138646 E012 31.0818326 0.0017444854 1.226470e-01 2.237286e-01 4 88470614 88470673 60 + 1.539 1.454 -0.290
ENSG00000138646 E013 39.0573840 0.0030153548 3.630054e-01 5.074324e-01 4 88472409 88472502 94 + 1.618 1.580 -0.131
ENSG00000138646 E014 0.0000000       4 88473010 88473012 3 +      
ENSG00000138646 E015 0.2966881 0.0290785164 3.235799e-01   4 88473013 88473125 113 + 0.185 0.000 -11.006
ENSG00000138646 E016 1.2125733 0.0109904224 8.439404e-01 9.028341e-01 4 88473126 88473889 764 + 0.368 0.341 -0.160
ENSG00000138646 E017 54.7107935 0.0005118254 6.071965e-02 1.278441e-01 4 88475841 88476030 190 + 1.773 1.698 -0.253
ENSG00000138646 E018 40.6946248 0.0011508290 6.454506e-02 1.342890e-01 4 88479353 88479507 155 + 1.655 1.566 -0.304
ENSG00000138646 E019 30.7284629 0.0007079630 3.994435e-02 9.093390e-02 4 88486115 88486228 114 + 1.545 1.429 -0.399
ENSG00000138646 E020 33.7107227 0.0006598476 7.330914e-01 8.243819e-01 4 88487069 88487179 111 + 1.521 1.556 0.119
ENSG00000138646 E021 60.1667885 0.0070511513 9.350799e-01 9.631339e-01 4 88489166 88489336 171 + 1.783 1.788 0.017
ENSG00000138646 E022 60.3881164 0.0018705452 9.676843e-01 9.838140e-01 4 88493012 88493155 144 + 1.781 1.796 0.053
ENSG00000138646 E023 58.3705799 0.0004424157 1.399303e-01 2.479296e-01 4 88494165 88494331 167 + 1.734 1.816 0.274
ENSG00000138646 E024 45.2573731 0.0006372150 2.093628e-02 5.345366e-02 4 88499926 88499992 67 + 1.598 1.732 0.454
ENSG00000138646 E025 51.3427880 0.0023431936 7.953670e-03 2.365982e-02 4 88500915 88500985 71 + 1.642 1.797 0.523
ENSG00000138646 E026 69.6020840 0.0004255175 3.593577e-04 1.616240e-03 4 88504232 88504415 184 + 1.769 1.931 0.544
ENSG00000138646 E027 1.2231678 0.0133684767 3.932383e-01 5.371303e-01 4 88504416 88504494 79 + 0.255 0.414 0.995
ENSG00000138646 E028 51.8677920 0.0004827157 1.151038e-05 7.542326e-05 4 88504495 88504597 103 + 1.607 1.831 0.761
ENSG00000138646 E029 97.4877186 0.0093168286 1.127192e-10 1.972502e-09 4 88505673 88506163 491 + 1.789 2.158 1.239