ENSG00000138617

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261888 ENSG00000138617 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP16 protein_coding protein_coding 8.492552 11.89127 5.247552 0.4179921 0.1908687 -1.178653 1.1757509 1.55512696 1.1894418 0.18249591 0.57056134 -0.3839165 0.13958750 0.130266667 0.2200000 0.08973333 0.72896859 0.00961657 FALSE TRUE
ENST00000560149 ENSG00000138617 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP16 protein_coding processed_transcript 8.492552 11.89127 5.247552 0.4179921 0.1908687 -1.178653 0.1076531 0.07431144 0.3095393 0.04915201 0.07853487 1.9221929 0.01575417 0.006533333 0.0598000 0.05326667 0.00961657 0.00961657 FALSE TRUE
ENST00000649807 ENSG00000138617 HEK293_OSMI2_2hA HEK293_TMG_2hB PARP16 protein_coding protein_coding 8.492552 11.89127 5.247552 0.4179921 0.1908687 -1.178653 6.4215368 8.86339797 3.2992945 0.86331591 0.47513058 -1.4229630 0.74939583 0.742333333 0.6343333 -0.10800000 0.70538325 0.00961657 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138617 E001 2.980852 0.0052229850 0.6470088658 0.758778815 15 65234460 65234632 173 - 0.481 0.571 0.426
ENSG00000138617 E002 4.087979 0.0040609321 0.7969472637 0.870438325 15 65234633 65234716 84 - 0.606 0.659 0.229
ENSG00000138617 E003 3.318300 0.0071017124 0.4418779690 0.583545053 15 65234717 65234766 50 - 0.657 0.546 -0.495
ENSG00000138617 E004 3.249312 0.0071649583 0.8363874660 0.897663634 15 65234767 65234823 57 - 0.548 0.594 0.210
ENSG00000138617 E005 2.101475 0.0083158933 0.7196586351 0.814420023 15 65248117 65248228 112 - 0.481 0.427 -0.273
ENSG00000138617 E006 0.000000       15 65258094 65258095 2 -      
ENSG00000138617 E007 0.000000       15 65258096 65258098 3 -      
ENSG00000138617 E008 358.083213 0.0032234949 0.0007879557 0.003216084 15 65258099 65259285 1187 - 2.417 2.519 0.341
ENSG00000138617 E009 82.912389 0.0015111519 0.0197450945 0.050950025 15 65259286 65259463 178 - 1.924 1.839 -0.286
ENSG00000138617 E010 54.576350 0.0005023395 0.3487667403 0.492998435 15 65259464 65259542 79 - 1.709 1.676 -0.109
ENSG00000138617 E011 5.920997 0.0031062722 0.0743173261 0.150452500 15 65259543 65259545 3 - 0.934 0.715 -0.859
ENSG00000138617 E012 83.032451 0.0004531567 0.5691449538 0.695757183 15 65260885 65261026 142 - 1.869 1.861 -0.026
ENSG00000138617 E013 88.181563 0.0003889984 0.3866964979 0.530877868 15 65263149 65263320 172 - 1.903 1.884 -0.064
ENSG00000138617 E014 39.027803 0.0005844107 0.9185377527 0.952510929 15 65266562 65266576 15 - 1.524 1.546 0.075
ENSG00000138617 E015 81.972348 0.0003925875 0.3280088416 0.471459827 15 65266577 65266768 192 - 1.811 1.870 0.196
ENSG00000138617 E016 38.786837 0.0006408063 0.1573605229 0.271591194 15 65270935 65270991 57 - 1.591 1.521 -0.236
ENSG00000138617 E017 36.270370 0.0020290998 0.2195326515 0.349829267 15 65270992 65271072 81 - 1.561 1.499 -0.215
ENSG00000138617 E018 0.000000       15 65282547 65282632 86 -      
ENSG00000138617 E019 75.858255 0.0004141675 0.0331298951 0.078065141 15 65286253 65286883 631 - 1.877 1.802 -0.254
ENSG00000138617 E020 0.000000       15 65300197 65300198 2 -      
ENSG00000138617 E021 1.851741 0.2596949717 0.9891865727 0.997288187 15 65300199 65300618 420 - 0.402 0.444 0.224