ENSG00000138614

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313182 ENSG00000138614 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS14 protein_coding protein_coding 42.62119 38.24771 51.23503 6.766492 0.8890672 0.4216613 24.885825 21.331201 32.144887 3.1871022 0.9778105 0.5913966 0.57495000 0.5630000 0.6273333 0.06433333 0.37825268 0.0003777462 FALSE TRUE
ENST00000573314 ENSG00000138614 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS14 protein_coding nonsense_mediated_decay 42.62119 38.24771 51.23503 6.766492 0.8890672 0.4216613 7.208371 6.810374 7.644828 0.7955889 0.6667392 0.1665190 0.17967917 0.1816333 0.1492000 -0.03243333 0.45191945 0.0003777462 FALSE TRUE
ENST00000652388 ENSG00000138614 HEK293_OSMI2_2hA HEK293_TMG_2hB INTS14 protein_coding protein_coding 42.62119 38.24771 51.23503 6.766492 0.8890672 0.4216613 3.813910 6.645827 2.003744 3.2879306 0.3242006 -1.7247375 0.09461667 0.1574000 0.0393000 -0.11810000 0.01444433 0.0003777462 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138614 E001 0.1482932 0.0411597534 4.440413e-01   15 65578753 65578756 4 - 0.000 0.127 10.756
ENSG00000138614 E002 0.5514428 0.0193874923 7.139804e-02 1.456550e-01 15 65578757 65578759 3 - 0.000 0.306 12.377
ENSG00000138614 E003 377.2824720 0.0010939929 5.970609e-12 1.288872e-10 15 65578760 65579026 267 - 2.489 2.659 0.565
ENSG00000138614 E004 310.5226084 0.0005285212 4.535615e-15 1.571719e-13 15 65579027 65579064 38 - 2.398 2.582 0.611
ENSG00000138614 E005 257.1866046 0.0002197361 3.811091e-17 1.723561e-15 15 65579065 65579096 32 - 2.308 2.506 0.660
ENSG00000138614 E006 264.8664434 0.0011765435 1.415008e-11 2.874735e-10 15 65579097 65579128 32 - 2.324 2.514 0.635
ENSG00000138614 E007 235.5905449 0.0032605879 2.655321e-04 1.239387e-03 15 65579129 65579146 18 - 2.304 2.441 0.457
ENSG00000138614 E008 396.5449355 0.0015326035 2.279583e-06 1.750903e-05 15 65579147 65579247 101 - 2.536 2.661 0.418
ENSG00000138614 E009 234.8575789 0.0007886721 3.027650e-03 1.034744e-02 15 65579248 65579273 26 - 2.336 2.420 0.282
ENSG00000138614 E010 673.5170306 0.0013028199 7.771774e-06 5.294470e-05 15 65579274 65579659 386 - 2.780 2.879 0.331
ENSG00000138614 E011 285.2005927 0.0012852456 9.241225e-03 2.688951e-02 15 65581954 65582019 66 - 2.423 2.501 0.258
ENSG00000138614 E012 300.7068931 0.0002002909 1.925534e-01 3.169659e-01 15 65584770 65584828 59 - 2.471 2.504 0.111
ENSG00000138614 E013 309.0110881 0.0001835464 1.121402e-01 2.086734e-01 15 65584829 65584888 60 - 2.479 2.518 0.128
ENSG00000138614 E014 1.1092308 0.0369603382 7.986296e-01 8.715171e-01 15 65586426 65586958 533 - 0.351 0.306 -0.283
ENSG00000138614 E015 408.2966997 0.0001456138 3.046694e-01 4.466942e-01 15 65591598 65591731 134 - 2.609 2.633 0.081
ENSG00000138614 E016 402.4453889 0.0001828988 5.095280e-01 6.448434e-01 15 65593428 65593569 142 - 2.617 2.610 -0.023
ENSG00000138614 E017 156.4634866 0.0002574767 1.796811e-03 6.589118e-03 15 65593570 65593572 3 - 2.245 2.162 -0.280
ENSG00000138614 E018 219.4888238 0.0018061209 2.091881e-01 3.375443e-01 15 65595733 65595764 32 - 2.369 2.328 -0.137
ENSG00000138614 E019 243.9593645 0.0013732025 6.119306e-02 1.286321e-01 15 65595765 65595825 61 - 2.421 2.367 -0.178
ENSG00000138614 E020 351.0711953 0.0001551271 1.672863e-03 6.196122e-03 15 65598321 65598463 143 - 2.582 2.527 -0.182
ENSG00000138614 E021 11.9321066 0.0113654984 2.797308e-06 2.108318e-05 15 65598464 65598865 402 - 1.313 0.786 -1.940
ENSG00000138614 E022 296.2776794 0.0001511134 4.262982e-01 5.691597e-01 15 65598872 65598990 119 - 2.487 2.476 -0.035
ENSG00000138614 E023 2.3627821 0.0064094828 1.166938e-05 7.635840e-05 15 65599377 65599773 397 - 0.776 0.000 -14.797
ENSG00000138614 E024 167.4651342 0.0002478408 2.189402e-01 3.491260e-01 15 65599774 65599809 36 - 2.248 2.220 -0.096
ENSG00000138614 E025 165.1101903 0.0020932139 4.968784e-01 6.334598e-01 15 65599810 65599837 28 - 2.239 2.212 -0.091
ENSG00000138614 E026 162.7498516 0.0029943571 1.612880e-01 2.767735e-01 15 65599838 65599846 9 - 2.248 2.189 -0.198
ENSG00000138614 E027 211.7639455 0.0005260033 5.315742e-03 1.679175e-02 15 65599847 65599882 36 - 2.369 2.299 -0.233
ENSG00000138614 E028 188.7716074 0.0002183109 6.762480e-04 2.812213e-03 15 65599883 65599896 14 - 2.327 2.244 -0.277
ENSG00000138614 E029 202.3136211 0.0001883242 4.890578e-06 3.489399e-05 15 65599897 65599929 33 - 2.368 2.259 -0.364
ENSG00000138614 E030 239.9946436 0.0001738515 3.289467e-07 3.018257e-06 15 65605129 65605182 54 - 2.444 2.331 -0.374
ENSG00000138614 E031 197.6910612 0.0001879149 1.312532e-09 1.903362e-08 15 65605183 65605202 20 - 2.375 2.227 -0.496
ENSG00000138614 E032 217.2179426 0.0002043893 5.331959e-08 5.713693e-07 15 65605203 65605232 30 - 2.406 2.279 -0.425
ENSG00000138614 E033 151.7478915 0.0014941442 5.368723e-06 3.793974e-05 15 65605233 65605236 4 - 2.262 2.106 -0.521
ENSG00000138614 E034 1.4833374 0.1420736081 5.280567e-01 6.609588e-01 15 65607147 65607158 12 - 0.458 0.309 -0.851
ENSG00000138614 E035 330.4276177 0.0018182220 1.227327e-07 1.225587e-06 15 65607159 65607301 143 - 2.597 2.443 -0.516
ENSG00000138614 E036 277.7630104 0.0053277077 7.716319e-06 5.260735e-05 15 65607302 65607425 124 - 2.539 2.341 -0.662
ENSG00000138614 E037 120.8340893 0.0006587525 4.547313e-10 7.176136e-09 15 65607426 65607442 17 - 2.188 1.979 -0.700
ENSG00000138614 E038 17.7226601 0.0078123047 5.006780e-02 1.092815e-01 15 65610686 65610795 110 - 1.357 1.176 -0.636
ENSG00000138614 E039 111.4470129 0.0032685885 1.522302e-01 2.647166e-01 15 65610796 65611097 302 - 2.088 2.020 -0.226
ENSG00000138614 E040 119.0953196 0.0046124745 1.918602e-06 1.498056e-05 15 65611098 65611289 192 - 2.187 1.960 -0.760