ENSG00000138604

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261858 ENSG00000138604 HEK293_OSMI2_2hA HEK293_TMG_2hB GLCE protein_coding protein_coding 12.13817 5.624416 18.73554 0.6550851 0.902265 1.734209 1.5723827 0.12310486 2.1502728 0.12310486 0.6545078 4.0205784 0.09933333 0.01776667 0.1168333 0.09906667 0.1193324376 0.0003315891 FALSE TRUE
ENST00000559420 ENSG00000138604 HEK293_OSMI2_2hA HEK293_TMG_2hB GLCE protein_coding protein_coding 12.13817 5.624416 18.73554 0.6550851 0.902265 1.734209 3.5261893 1.36407224 4.9543091 0.22115836 0.4980765 1.8531351 0.28481667 0.24876667 0.2633000 0.01453333 0.9059047358 0.0003315891 FALSE TRUE
ENST00000559798 ENSG00000138604 HEK293_OSMI2_2hA HEK293_TMG_2hB GLCE protein_coding processed_transcript 12.13817 5.624416 18.73554 0.6550851 0.902265 1.734209 1.7342608 1.48724097 2.3707139 0.30738077 0.2799277 0.6690878 0.15173333 0.25936667 0.1260667 -0.13330000 0.0022625188 0.0003315891 FALSE FALSE
MSTRG.11113.1 ENSG00000138604 HEK293_OSMI2_2hA HEK293_TMG_2hB GLCE protein_coding   12.13817 5.624416 18.73554 0.6550851 0.902265 1.734209 1.4067754 0.06690235 2.4650960 0.03426045 0.5270786 5.0083131 0.07942083 0.01120000 0.1346333 0.12343333 0.0003315891 0.0003315891 FALSE TRUE
MSTRG.11113.2 ENSG00000138604 HEK293_OSMI2_2hA HEK293_TMG_2hB GLCE protein_coding   12.13817 5.624416 18.73554 0.6550851 0.902265 1.734209 0.8223760 0.31163204 0.8376646 0.16734090 0.4404614 1.3980825 0.06227917 0.05660000 0.0458000 -0.01080000 1.0000000000 0.0003315891 FALSE TRUE
MSTRG.11113.4 ENSG00000138604 HEK293_OSMI2_2hA HEK293_TMG_2hB GLCE protein_coding   12.13817 5.624416 18.73554 0.6550851 0.902265 1.734209 0.3221496 0.00000000 1.5192578 0.00000000 1.5192578 7.2566878 0.02210833 0.00000000 0.0740000 0.07400000 1.0000000000 0.0003315891   FALSE
MSTRG.11113.5 ENSG00000138604 HEK293_OSMI2_2hA HEK293_TMG_2hB GLCE protein_coding   12.13817 5.624416 18.73554 0.6550851 0.902265 1.734209 2.5001166 2.16098104 3.7608287 0.09636951 0.4153221 0.7965345 0.27972917 0.39033333 0.2036667 -0.18666667 0.0144807616 0.0003315891 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138604 E001 1.0308689 0.0135711561 7.228079e-01 8.168373e-01 15 69160556 69160557 2 + 0.275 0.342 0.442
ENSG00000138604 E002 3.3714005 0.1928883440 4.005438e-01 5.442328e-01 15 69160558 69160574 17 + 0.654 0.439 -1.004
ENSG00000138604 E003 4.7774056 0.1064000925 9.386251e-01 9.654565e-01 15 69160575 69160575 1 + 0.718 0.716 -0.008
ENSG00000138604 E004 5.3706681 0.0479276599 7.683785e-01 8.503292e-01 15 69160576 69160583 8 + 0.773 0.716 -0.233
ENSG00000138604 E005 22.7926013 0.0008954954 8.073682e-01 8.776265e-01 15 69160584 69160634 51 + 1.328 1.305 -0.080
ENSG00000138604 E006 47.4058027 0.0005177534 4.520107e-01 5.929049e-01 15 69160635 69160757 123 + 1.642 1.596 -0.159
ENSG00000138604 E007 14.3141817 0.0022117431 1.477627e-02 3.998915e-02 15 69194436 69194525 90 + 1.064 1.292 0.812
ENSG00000138604 E008 129.0226965 0.0003476617 2.396690e-40 8.502730e-38 15 69196415 69197458 1044 + 1.920 2.319 1.334
ENSG00000138604 E009 21.2712568 0.0110346917 1.347892e-03 5.135948e-03 15 69210316 69210406 91 + 1.369 1.023 -1.233
ENSG00000138604 E010 0.7448917 0.0702434089 2.601831e-01 3.976623e-01 15 69228184 69228247 64 + 0.275 0.000 -10.347
ENSG00000138604 E011 94.3887065 0.0014281126 5.018168e-19 2.862622e-17 15 69255794 69256392 599 + 2.009 1.531 -1.616
ENSG00000138604 E012 1.6692976 0.0089507351 2.449451e-01 3.799723e-01 15 69260285 69260402 118 + 0.442 0.204 -1.556
ENSG00000138604 E013 0.1451727 0.0435894891 1.000000e+00   15 69260696 69261086 391 + 0.071 0.000 -8.237
ENSG00000138604 E014 55.3312809 0.0004079524 8.578598e-13 2.130000e-11 15 69261087 69261329 243 + 1.780 1.305 -1.627
ENSG00000138604 E015 4.7591360 0.0483128852 4.355284e-01 5.777591e-01 15 69266775 69266966 192 + 0.748 0.602 -0.618
ENSG00000138604 E016 531.9227866 0.0002351582 8.266283e-01 8.909138e-01 15 69268220 69272217 3998 + 2.675 2.669 -0.019