ENSG00000138594

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308580 ENSG00000138594 HEK293_OSMI2_2hA HEK293_TMG_2hB TMOD3 protein_coding protein_coding 7.405582 2.013826 12.59 0.05658673 0.5806244 2.638266 1.492194 0.7541216 2.488670 0.1596515 0.1023103 1.709286 0.2900750 0.3731000 0.1979333 -0.17516667 7.493715e-02 1.51511e-07 FALSE TRUE
MSTRG.10816.3 ENSG00000138594 HEK293_OSMI2_2hA HEK293_TMG_2hB TMOD3 protein_coding   7.405582 2.013826 12.59 0.05658673 0.5806244 2.638266 4.322370 0.9684566 7.326834 0.2252929 0.4548892 2.906578 0.5283708 0.4848667 0.5827000 0.09783333 7.347312e-01 1.51511e-07 TRUE TRUE
MSTRG.10816.5 ENSG00000138594 HEK293_OSMI2_2hA HEK293_TMG_2hB TMOD3 protein_coding   7.405582 2.013826 12.59 0.05658673 0.5806244 2.638266 1.101769 0.0000000 2.253966 0.0000000 0.3924146 7.822708 0.0882625 0.0000000 0.1773333 0.17733333 1.515110e-07 1.51511e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138594 E001 0.0000000       15 51829628 51829636 9 +      
ENSG00000138594 E002 0.4741261 0.0217681645 4.678784e-01 0.6073269431 15 51829637 51829652 16 + 0.106 0.248 1.481
ENSG00000138594 E003 22.0966204 0.0009089822 1.190420e-01 0.2185750943 15 51829653 51829782 130 + 1.267 1.171 -0.338
ENSG00000138594 E004 23.8542712 0.0027689881 9.194611e-02 0.1781421236 15 51829783 51829836 54 + 1.301 1.193 -0.379
ENSG00000138594 E005 1.3016330 0.0601031597 5.763294e-01 0.7017864580 15 51834994 51835058 65 + 0.262 0.406 0.900
ENSG00000138594 E006 71.1715453 0.0003524156 1.597219e-05 0.0001013156 15 51862811 51863010 200 + 1.773 1.579 -0.659
ENSG00000138594 E007 73.5298325 0.0016944361 1.502954e-03 0.0056453731 15 51869217 51869373 157 + 1.778 1.651 -0.429
ENSG00000138594 E008 0.0000000       15 51875026 51875270 245 +      
ENSG00000138594 E009 52.4645743 0.0004125760 9.601855e-02 0.1843954427 15 51887589 51887711 123 + 1.624 1.579 -0.154
ENSG00000138594 E010 46.6699246 0.0022332612 1.031546e-01 0.1952787337 15 51889056 51889145 90 + 1.577 1.522 -0.189
ENSG00000138594 E011 55.5160020 0.0050831997 4.372143e-01 0.5792152687 15 51893815 51893945 131 + 1.640 1.650 0.031
ENSG00000138594 E012 63.4892913 0.0004325889 2.929200e-01 0.4339511971 15 51896419 51896526 108 + 1.693 1.694 0.002
ENSG00000138594 E013 74.5385866 0.0004136387 1.867296e-01 0.3096311607 15 51900155 51900298 144 + 1.766 1.757 -0.030
ENSG00000138594 E014 0.0000000       15 51901266 51901492 227 +      
ENSG00000138594 E015 69.6131674 0.0004125846 6.353800e-02 0.1325874515 15 51901892 51902036 145 + 1.743 1.701 -0.142
ENSG00000138594 E016 49.2674087 0.0004431367 1.099901e-03 0.0043030020 15 51908776 51908862 87 + 1.614 1.446 -0.576
ENSG00000138594 E017 32.2297591 0.0006507309 2.785927e-05 0.0001669309 15 51908863 51908876 14 + 1.456 1.124 -1.164
ENSG00000138594 E018 330.3179821 0.0134290481 4.427128e-01 0.5842932245 15 51908877 51911013 2137 + 2.387 2.476 0.299
ENSG00000138594 E019 30.9559171 0.0083059753 3.473170e-02 0.0811361510 15 51911014 51911039 26 + 1.341 1.577 0.813
ENSG00000138594 E020 46.9695574 0.0048031046 6.313329e-02 0.1319319303 15 51911040 51911152 113 + 1.531 1.719 0.639
ENSG00000138594 E021 168.5161437 0.0182435218 2.413098e-04 0.0011388712 15 51911153 51915725 4573 + 2.043 2.350 1.027
ENSG00000138594 E022 1.9080308 0.1053458541 7.520354e-02 0.1518587656 15 51916015 51916133 119 + 0.293 0.685 1.994
ENSG00000138594 E023 0.0000000       15 51921494 51921495 2 +      
ENSG00000138594 E024 0.4751703 0.0207010532 5.688291e-02 0.1212604691 15 51921496 51921508 13 + 0.056 0.404 3.479
ENSG00000138594 E025 0.9890372 0.0132541456 6.742202e-02 0.1390728288 15 51921509 51921616 108 + 0.150 0.519 2.481
ENSG00000138594 E026 0.1515154 0.0425611703 1.000000e+00   15 51924392 51924578 187 + 0.056 0.000 -9.344
ENSG00000138594 E027 0.0000000       15 51929433 51929454 22 +      
ENSG00000138594 E028 0.5879639 0.0223304501 6.814291e-01 0.7851233592 15 51931031 51931051 21 + 0.150 0.247 0.893
ENSG00000138594 E029 0.7425998 0.0584479586 2.532427e-01 0.3897382167 15 51931052 51931133 82 + 0.150 0.403 1.885
ENSG00000138594 E030 0.5922303 0.0179983650 6.803911e-01 0.7842809039 15 51931134 51931308 175 + 0.150 0.247 0.894
ENSG00000138594 E031 0.4438354 0.0543387373 6.333816e-02 0.1322578260 15 51933977 51934202 226 + 0.056 0.403 3.471
ENSG00000138594 E032 0.2965864 0.0838890305 1.684124e-02   15 51934203 51934249 47 + 0.000 0.402 15.015
ENSG00000138594 E033 1.1383745 0.0120373075 1.756302e-03 0.0064599495 15 51934250 51934354 105 + 0.106 0.685 3.801
ENSG00000138594 E034 0.8200183 0.0160477492 2.311802e-01 0.3638783355 15 51936630 51937054 425 + 0.150 0.404 1.895
ENSG00000138594 E035 1.0641783 0.0144692065 1.892652e-02 0.0491713153 15 51946990 51947295 306 + 0.150 0.609 2.892