ENSG00000138468

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314261 ENSG00000138468 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP7 protein_coding protein_coding 3.281476 1.02655 4.680122 0.3303978 0.03855151 2.177836 0.26606862 0.03338133 0.3857292 0.03338133 0.11859486 3.1893677 0.11483750 0.02993333 0.08230000 0.05236667 5.632645e-01 3.283274e-09 FALSE TRUE
ENST00000348610 ENSG00000138468 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP7 protein_coding protein_coding 3.281476 1.02655 4.680122 0.3303978 0.03855151 2.177836 0.98421398 0.00000000 1.4982951 0.00000000 0.11614677 7.2367749 0.18598750 0.00000000 0.31980000 0.31980000 3.283274e-09 3.283274e-09 FALSE TRUE
ENST00000366089 ENSG00000138468 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP7 protein_coding protein_coding 3.281476 1.02655 4.680122 0.3303978 0.03855151 2.177836 0.41352086 0.55237177 0.3235730 0.21910175 0.09608730 -0.7535218 0.24259167 0.48823333 0.06883333 -0.41940000 1.903580e-06 3.283274e-09   FALSE
ENST00000394085 ENSG00000138468 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP7 protein_coding protein_coding 3.281476 1.02655 4.680122 0.3303978 0.03855151 2.177836 0.26593759 0.06799543 0.3253153 0.04908138 0.14894410 2.1040570 0.07481667 0.04730000 0.07003333 0.02273333 1.000000e+00 3.283274e-09 FALSE TRUE
ENST00000394091 ENSG00000138468 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP7 protein_coding protein_coding 3.281476 1.02655 4.680122 0.3303978 0.03855151 2.177836 0.02761469 0.15482767 0.0000000 0.12236995 0.00000000 -4.0428865 0.02101250 0.10563333 0.00000000 -0.10563333 5.975643e-03 3.283274e-09 FALSE TRUE
ENST00000394094 ENSG00000138468 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP7 protein_coding protein_coding 3.281476 1.02655 4.680122 0.3303978 0.03855151 2.177836 0.61957602 0.07400759 1.4970427 0.05213703 0.20265876 4.1650568 0.14749583 0.09026667 0.32043333 0.23016667 5.278853e-02 3.283274e-09 FALSE TRUE
ENST00000394095 ENSG00000138468 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP7 protein_coding protein_coding 3.281476 1.02655 4.680122 0.3303978 0.03855151 2.177836 0.19754043 0.14396586 0.0000000 0.05051693 0.00000000 -3.9445386 0.11612083 0.23866667 0.00000000 -0.23866667 2.485635e-03 3.283274e-09 FALSE TRUE
MSTRG.23359.5 ENSG00000138468 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP7 protein_coding   3.281476 1.02655 4.680122 0.3303978 0.03855151 2.177836 0.35472551 0.00000000 0.4216976 0.00000000 0.06342128 5.4319492 0.06356250 0.00000000 0.08990000 0.08990000 6.542121e-03 3.283274e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138468 E001 0.000000       3 101324205 101324272 68 -      
ENSG00000138468 E002 37.937780 0.0096562258 1.415635e-12 3.382793e-11 3 101324273 101325539 1267 - 1.304 1.839 1.829
ENSG00000138468 E003 20.129398 0.0030712276 4.988944e-02 1.089750e-01 3 101325540 101325866 327 - 1.118 1.335 0.766
ENSG00000138468 E004 24.165369 0.0007780007 7.463080e-01 8.341248e-01 3 101325867 101326080 214 - 1.224 1.273 0.175
ENSG00000138468 E005 23.311834 0.0008049108 1.272481e-01 2.303019e-01 3 101327666 101327816 151 - 1.190 1.352 0.570
ENSG00000138468 E006 14.433422 0.0032376559 3.680502e-02 8.509710e-02 3 101328478 101328546 69 - 1.058 0.754 -1.156
ENSG00000138468 E007 11.435419 0.0023434710 3.330629e-01 4.767313e-01 3 101328646 101328689 44 - 0.951 0.820 -0.498
ENSG00000138468 E008 12.881064 0.0015167634 8.439558e-01 9.028403e-01 3 101330334 101330386 53 - 0.972 1.015 0.159
ENSG00000138468 E009 14.593706 0.0013811651 1.908835e-01 3.148465e-01 3 101331985 101332109 125 - 1.045 0.878 -0.623
ENSG00000138468 E010 10.612464 0.0016256495 2.360684e-01 3.696222e-01 3 101332770 101332862 93 - 0.879 1.053 0.647
ENSG00000138468 E011 2.306466 0.0124455061 3.327808e-01 4.764607e-01 3 101332863 101333269 407 - 0.373 0.580 1.044
ENSG00000138468 E012 2.074399 0.0756551244 1.644831e-01 2.810136e-01 3 101337129 101337508 380 - 0.413 0.001 -9.744
ENSG00000138468 E013 11.515870 0.0015609949 5.672890e-01 6.941194e-01 3 101337509 101337631 123 - 0.945 0.878 -0.255
ENSG00000138468 E014 9.747119 0.0244444676 4.072321e-01 5.508156e-01 3 101340095 101340211 117 - 0.891 0.754 -0.535
ENSG00000138468 E015 0.000000       3 101340212 101340425 214 -      
ENSG00000138468 E016 11.377358 0.0159444521 8.536245e-02 1.679911e-01 3 101341646 101341779 134 - 0.961 0.676 -1.123
ENSG00000138468 E017 18.360348 0.0010545358 1.205243e-02 3.365907e-02 3 101343686 101343954 269 - 1.154 0.820 -1.240
ENSG00000138468 E018 0.000000       3 101347326 101347718 393 -      
ENSG00000138468 E019 16.693940 0.0012438955 2.705692e-01 4.092269e-01 3 101347872 101348051 180 - 1.099 0.974 -0.457
ENSG00000138468 E020 7.351191 0.0038637472 8.190649e-01 8.857408e-01 3 101351618 101351651 34 - 0.777 0.754 -0.092
ENSG00000138468 E021 11.854149 0.0017276391 2.782949e-01 4.179619e-01 3 101361715 101361861 147 - 0.967 0.820 -0.559
ENSG00000138468 E022 14.533781 0.0013508828 2.903693e-03 9.980151e-03 3 101364834 101364991 158 - 1.066 0.580 -1.924
ENSG00000138468 E023 23.324502 0.0008778606 1.483063e-01 2.593670e-01 3 101366430 101366769 340 - 1.233 1.087 -0.519
ENSG00000138468 E024 17.830558 0.0010200843 4.183656e-02 9.442717e-02 3 101367830 101368011 182 - 1.136 0.878 -0.955
ENSG00000138468 E025 15.563757 0.0012270287 2.252979e-01 3.567686e-01 3 101372008 101372126 119 - 1.075 0.928 -0.540
ENSG00000138468 E026 11.446492 0.0435080770 6.832114e-01 7.864881e-01 3 101398861 101399055 195 - 0.944 0.879 -0.248
ENSG00000138468 E027 18.289466 0.0454652634 9.638088e-01 9.811534e-01 3 101417593 101417790 198 - 1.121 1.120 -0.004
ENSG00000138468 E028 15.692879 0.0011751146 8.592258e-01 9.131735e-01 3 101458955 101459052 98 - 1.058 1.053 -0.018
ENSG00000138468 E029 14.835778 0.0012197923 1.691603e-01 2.870918e-01 3 101493873 101493968 96 - 1.053 0.878 -0.655
ENSG00000138468 E030 7.727715 0.0027786362 7.439194e-01 8.324082e-01 3 101501070 101501119 50 - 0.793 0.754 -0.156
ENSG00000138468 E031 8.949725 0.0019220953 5.460989e-01 6.763385e-01 3 101513091 101513241 151 - 0.824 0.929 0.402