ENSG00000138448

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261023 ENSG00000138448 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGAV protein_coding protein_coding 6.468072 0.8083256 11.6493 0.0329983 0.252582 3.832663 2.8580868 0.1387059 6.390683 0.13870595 0.9428374 5.427692 0.3716417 0.1668000 0.5480000 0.3812000 1.663225e-01 8.948369e-20 FALSE TRUE
ENST00000374907 ENSG00000138448 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGAV protein_coding protein_coding 6.468072 0.8083256 11.6493 0.0329983 0.252582 3.832663 0.1100422 0.1243474 0.000000 0.08082229 0.0000000 -3.747897 0.0729250 0.1618333 0.0000000 -0.1618333 6.897448e-03 8.948369e-20 FALSE TRUE
ENST00000433736 ENSG00000138448 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGAV protein_coding protein_coding 6.468072 0.8083256 11.6493 0.0329983 0.252582 3.832663 0.5356928 0.5171979 0.000000 0.07733150 0.0000000 -5.720273 0.1978292 0.6383667 0.0000000 -0.6383667 8.948369e-20 8.948369e-20 FALSE TRUE
MSTRG.19630.1 ENSG00000138448 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGAV protein_coding   6.468072 0.8083256 11.6493 0.0329983 0.252582 3.832663 0.8837228 0.0000000 1.668649 0.00000000 0.8034076 7.391157 0.1540458 0.0000000 0.1443333 0.1443333 3.670666e-02 8.948369e-20 FALSE TRUE
MSTRG.19630.4 ENSG00000138448 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGAV protein_coding   6.468072 0.8083256 11.6493 0.0329983 0.252582 3.832663 1.4927011 0.0000000 2.998301 0.00000000 0.3971204 8.232805 0.1237458 0.0000000 0.2588333 0.2588333 1.228086e-05 8.948369e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138448 E001 6.1578585 0.0140209619 7.298902e-01 8.219872e-01 2 186590034 186590055 22 + 0.533 0.770 1.017
ENSG00000138448 E002 8.3710878 0.0126847137 8.381132e-01 8.987775e-01 2 186590056 186590079 24 + 0.643 0.770 0.525
ENSG00000138448 E003 20.0010004 0.0009276797 2.218891e-01 3.526500e-01 2 186590080 186590297 218 + 0.971 0.960 -0.040
ENSG00000138448 E004 34.7278785 0.0005746918 1.072429e-02 3.050852e-02 2 186590298 186590523 226 + 1.199 1.031 -0.604
ENSG00000138448 E005 0.0000000       2 186600205 186600381 177 +      
ENSG00000138448 E006 38.5692050 0.0005578180 1.055519e-01 1.989363e-01 2 186602021 186602151 131 + 1.235 1.236 0.005
ENSG00000138448 E007 27.3653472 0.0007345032 1.638620e-01 2.801780e-01 2 186622339 186622430 92 + 1.096 1.092 -0.015
ENSG00000138448 E008 33.6476683 0.0013424263 3.841328e-02 8.812507e-02 2 186625473 186625587 115 + 1.182 1.092 -0.323
ENSG00000138448 E009 17.4909865 0.0009988185 2.933726e-03 1.006858e-02 2 186630797 186630799 3 + 0.936 0.419 -2.233
ENSG00000138448 E010 29.8239000 0.0030514137 1.321964e-03 5.049948e-03 2 186630800 186630858 59 + 1.142 0.769 -1.399
ENSG00000138448 E011 29.0365718 0.0006595765 1.491450e-03 5.608613e-03 2 186633329 186633374 46 + 1.131 0.769 -1.362
ENSG00000138448 E012 49.3329791 0.0004894731 4.111951e-04 1.817284e-03 2 186636082 186636207 126 + 1.346 1.092 -0.899
ENSG00000138448 E013 35.5971008 0.0005528269 1.042353e-01 1.969468e-01 2 186637065 186637109 45 + 1.202 1.193 -0.032
ENSG00000138448 E014 37.8279473 0.0005504810 1.226234e-01 2.236963e-01 2 186638277 186638320 44 + 1.227 1.236 0.035
ENSG00000138448 E015 36.3739041 0.0006076390 4.239802e-01 5.669920e-01 2 186638409 186638465 57 + 1.206 1.311 0.371
ENSG00000138448 E016 30.5503982 0.0035346715 2.878811e-01 4.284193e-01 2 186640915 186640967 53 + 1.139 1.193 0.193
ENSG00000138448 E017 48.9607075 0.0012957017 1.022975e-02 2.932979e-02 2 186641386 186641588 203 + 1.339 1.236 -0.358
ENSG00000138448 E018 38.7709592 0.0005652566 9.448157e-03 2.740503e-02 2 186646686 186646877 192 + 1.243 1.092 -0.538
ENSG00000138448 E019 17.1619168 0.0010715982 7.736829e-02 1.552570e-01 2 186649840 186649885 46 + 0.919 0.769 -0.585
ENSG00000138448 E020 27.6332928 0.0006992141 2.389016e-03 8.426900e-03 2 186651982 186652089 108 + 1.112 0.769 -1.293
ENSG00000138448 E021 22.3044764 0.0008094720 1.473185e-02 3.988603e-02 2 186654650 186654708 59 + 1.025 0.769 -0.977
ENSG00000138448 E022 44.9171805 0.0004976659 1.577001e-03 5.884191e-03 2 186656247 186656401 155 + 1.306 1.092 -0.760
ENSG00000138448 E023 43.6549582 0.0005382049 3.429422e-02 8.032016e-02 2 186659038 186659175 138 + 1.289 1.236 -0.185
ENSG00000138448 E024 33.0345329 0.1131043782 2.260260e-01 3.576353e-01 2 186663768 186663835 68 + 1.174 1.147 -0.099
ENSG00000138448 E025 53.7006036 0.0004573071 1.465869e-02 3.972448e-02 2 186664494 186664641 148 + 1.376 1.311 -0.225
ENSG00000138448 E026 45.9363665 0.0005185004 4.074923e-02 9.241307e-02 2 186665126 186665218 93 + 1.310 1.275 -0.122
ENSG00000138448 E027 33.3171611 0.0024047926 4.401980e-01 5.818863e-01 2 186666704 186666783 80 + 1.173 1.275 0.362
ENSG00000138448 E028 36.2604965 0.0075132781 5.212483e-02 1.129450e-01 2 186667150 186667230 81 + 1.216 1.145 -0.253
ENSG00000138448 E029 0.2924217 0.0290785164 8.916873e-01   2 186667648 186667670 23 + 0.053 0.000 -12.557
ENSG00000138448 E030 42.5148162 0.0005753745 4.340617e-02 9.730640e-02 2 186667671 186667776 106 + 1.279 1.236 -0.149
ENSG00000138448 E031 0.4427912 0.1685790322 1.273441e-01 2.304383e-01 2 186667777 186668020 244 + 0.053 0.416 3.624
ENSG00000138448 E032 0.1515154 0.0422368247 4.062768e-01   2 186668524 186668761 238 + 0.027 0.000 -11.558
ENSG00000138448 E033 30.9643837 0.0006519299 2.602978e-01 3.977820e-01 2 186668762 186668844 83 + 1.143 1.193 0.178
ENSG00000138448 E034 23.8021732 0.0007766331 8.982883e-03 2.623775e-02 2 186668845 186668876 32 + 1.051 0.769 -1.072
ENSG00000138448 E035 27.1802817 0.0006852759 3.345452e-02 7.868452e-02 2 186668877 186668920 44 + 1.098 0.960 -0.508
ENSG00000138448 E036 44.5126654 0.0005351562 1.057067e-01 1.991706e-01 2 186669701 186669814 114 + 1.294 1.311 0.063
ENSG00000138448 E037 0.1451727 0.0427893701 4.055029e-01   2 186669815 186669957 143 + 0.027 0.000 -11.557
ENSG00000138448 E038 42.0860794 0.0037469000 4.199721e-01 5.632201e-01 2 186675604 186675717 114 + 1.265 1.375 0.384
ENSG00000138448 E039 33.7104231 0.0006093564 3.602829e-02 8.364113e-02 2 186675820 186675927 108 + 1.184 1.092 -0.330
ENSG00000138448 E040 0.0000000       2 186675928 186676283 356 +      
ENSG00000138448 E041 43.4388069 0.0013364872 3.926234e-02 8.964907e-02 2 186676813 186676935 123 + 1.285 1.237 -0.169
ENSG00000138448 E042 395.1198990 0.0169161761 2.749628e-20 1.814532e-18 2 186677197 186680901 3705 + 2.162 2.791 2.096