ENSG00000138443

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261017 ENSG00000138443 HEK293_OSMI2_2hA HEK293_TMG_2hB ABI2 protein_coding protein_coding 25.61687 17.25786 28.48427 0.2491667 1.34192 0.7225824 5.594537 4.7085121 5.659038 0.5167161 0.3154720 0.2647719 0.23585000 0.27233333 0.20066667 -0.071666667 2.876078e-01 2.828307e-09 FALSE TRUE
ENST00000376135 ENSG00000138443 HEK293_OSMI2_2hA HEK293_TMG_2hB ABI2 protein_coding processed_transcript 25.61687 17.25786 28.48427 0.2491667 1.34192 0.7225824 3.958845 2.1362220 3.401065 1.0693539 1.0906522 0.6684230 0.15210417 0.12480000 0.11696667 -0.007833333 9.361075e-01 2.828307e-09 FALSE TRUE
ENST00000441061 ENSG00000138443 HEK293_OSMI2_2hA HEK293_TMG_2hB ABI2 protein_coding nonsense_mediated_decay 25.61687 17.25786 28.48427 0.2491667 1.34192 0.7225824 1.117577 0.0000000 1.981706 0.0000000 0.4616447 7.6378605 0.03706667 0.00000000 0.07043333 0.070433333 2.828307e-09 2.828307e-09 FALSE TRUE
ENST00000454023 ENSG00000138443 HEK293_OSMI2_2hA HEK293_TMG_2hB ABI2 protein_coding protein_coding 25.61687 17.25786 28.48427 0.2491667 1.34192 0.7225824 9.072712 7.9276378 8.524061 0.9864329 0.3913535 0.1045226 0.36019583 0.45846667 0.29986667 -0.158600000 6.494933e-02 2.828307e-09 FALSE TRUE
MSTRG.19825.8 ENSG00000138443 HEK293_OSMI2_2hA HEK293_TMG_2hB ABI2 protein_coding   25.61687 17.25786 28.48427 0.2491667 1.34192 0.7225824 2.299823 0.2505121 3.566988 0.2505121 0.3040268 3.7793232 0.07427500 0.01433333 0.12606667 0.111733333 4.838359e-02 2.828307e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138443 E001 0.4439371 0.0215512285 1.624928e-01 2.783896e-01 2 203327609 203328279 671 + 0.257 0.000 -10.942
ENSG00000138443 E002 0.3268771 0.0286997378 7.820771e-01   2 203328280 203328281 2 + 0.103 0.144 0.549
ENSG00000138443 E003 4.2856103 0.0236642830 7.268438e-01 8.197601e-01 2 203328282 203328358 77 + 0.747 0.693 -0.219
ENSG00000138443 E004 9.5400811 0.0033277875 4.427982e-01 5.843611e-01 2 203328359 203328390 32 + 0.983 1.065 0.303
ENSG00000138443 E005 9.6852538 0.0034321416 5.106125e-01 6.458061e-01 2 203328391 203328391 1 + 0.995 1.065 0.258
ENSG00000138443 E006 9.5035494 0.0020729665 6.064262e-01 7.265724e-01 2 203328392 203328393 2 + 0.995 1.050 0.204
ENSG00000138443 E007 9.2821042 0.0023787535 7.168389e-01 8.123839e-01 2 203328394 203328394 1 + 0.995 1.035 0.147
ENSG00000138443 E008 9.7228191 0.0019449896 7.668435e-01 8.492258e-01 2 203328395 203328398 4 + 1.018 1.050 0.119
ENSG00000138443 E009 9.5713037 0.0020688939 6.867408e-01 7.891891e-01 2 203328399 203328401 3 + 1.006 1.050 0.160
ENSG00000138443 E010 10.7912519 0.0018697764 9.406878e-01 9.667279e-01 2 203328402 203328404 3 + 1.071 1.080 0.033
ENSG00000138443 E011 12.0789648 0.0082559471 6.676924e-01 7.748619e-01 2 203328405 203328406 2 + 1.099 1.145 0.163
ENSG00000138443 E012 37.3989579 0.0084614169 4.539905e-01 5.946808e-01 2 203328407 203328457 51 + 1.608 1.552 -0.192
ENSG00000138443 E013 32.2372032 0.0071122917 4.261032e-01 5.689594e-01 2 203328458 203328458 1 + 1.546 1.485 -0.210
ENSG00000138443 E014 39.1160961 0.0182516683 4.657623e-01 6.053849e-01 2 203328459 203328483 25 + 1.630 1.560 -0.241
ENSG00000138443 E015 42.7707780 0.0272367363 6.409276e-01 7.540510e-01 2 203328484 203328514 31 + 1.659 1.610 -0.168
ENSG00000138443 E016 85.5567366 0.0058266038 3.639133e-01 5.083302e-01 2 203328515 203328631 117 + 1.959 1.906 -0.177
ENSG00000138443 E017 0.0000000       2 203342197 203342230 34 +      
ENSG00000138443 E018 0.9148515 0.0268989588 5.792353e-03 1.806744e-02 2 203351555 203351678 124 + 0.000 0.473 13.875
ENSG00000138443 E019 0.4386386 0.1589091300 8.330314e-01 8.953806e-01 2 203355154 203355324 171 + 0.187 0.143 -0.463
ENSG00000138443 E020 44.4640011 0.0031083873 4.734705e-01 6.124163e-01 2 203366877 203366880 4 + 1.636 1.676 0.137
ENSG00000138443 E021 43.4049349 0.0022422477 7.032872e-01 8.019867e-01 2 203366881 203366883 3 + 1.636 1.658 0.073
ENSG00000138443 E022 65.2594736 0.0006557976 8.805592e-01 9.273870e-01 2 203366884 203366922 39 + 1.822 1.816 -0.019
ENSG00000138443 E023 89.7518990 0.0034400366 4.040109e-01 5.477410e-01 2 203366923 203366996 74 + 1.974 1.931 -0.143
ENSG00000138443 E024 76.5231419 0.0021462861 5.813846e-01 7.059208e-01 2 203366997 203367044 48 + 1.899 1.873 -0.089
ENSG00000138443 E025 3.6932426 0.0058252813 1.128136e-01 2.096485e-01 2 203367045 203367419 375 + 0.767 0.526 -1.038
ENSG00000138443 E026 0.0000000       2 203374820 203374852 33 +      
ENSG00000138443 E027 0.2966881 0.0270571563 3.302910e-01   2 203375932 203376056 125 + 0.187 0.000 -12.644
ENSG00000138443 E028 11.9614723 0.0015647644 3.628740e-03 1.209327e-02 2 203376057 203376132 76 + 1.220 0.928 -1.062
ENSG00000138443 E029 48.8018697 0.0010441777 5.074073e-01 6.429499e-01 2 203380208 203380211 4 + 1.713 1.679 -0.112
ENSG00000138443 E030 55.7186315 0.0005005468 3.973780e-01 5.411417e-01 2 203380212 203380225 14 + 1.772 1.733 -0.131
ENSG00000138443 E031 77.9737931 0.0054537728 3.579530e-01 5.023495e-01 2 203380226 203380274 49 + 1.921 1.869 -0.175
ENSG00000138443 E032 71.5929608 0.0052725392 7.228744e-01 8.168783e-01 2 203380275 203380307 33 + 1.853 1.868 0.052
ENSG00000138443 E033 69.1241613 0.0029015893 2.108219e-01 3.395270e-01 2 203380308 203380357 50 + 1.819 1.880 0.208
ENSG00000138443 E034 56.7071150 0.0020185579 4.406999e-02 9.851009e-02 2 203380358 203380384 27 + 1.715 1.818 0.348
ENSG00000138443 E035 0.1515154 0.0431511277 7.014688e-01   2 203382189 203382206 18 + 0.104 0.000 -11.455
ENSG00000138443 E036 1.6242331 0.0083179419 1.451997e-03 5.480265e-03 2 203383247 203383296 50 + 0.598 0.000 -15.365
ENSG00000138443 E037 0.1472490 0.0428813015 7.014820e-01   2 203391044 203391045 2 + 0.104 0.000 -11.457
ENSG00000138443 E038 97.8103259 0.0003324124 1.411451e-01 2.496127e-01 2 203391046 203391143 98 + 1.974 2.028 0.183
ENSG00000138443 E039 82.2245066 0.0004015798 6.504982e-02 1.351186e-01 2 203394700 203394747 48 + 1.887 1.961 0.248
ENSG00000138443 E040 110.5638439 0.0012448880 4.831949e-01 6.212409e-01 2 203394748 203394846 99 + 2.038 2.066 0.092
ENSG00000138443 E041 54.2607414 0.0004662744 3.589352e-01 5.032831e-01 2 203395656 203395658 3 + 1.724 1.769 0.154
ENSG00000138443 E042 140.8211650 0.0069938353 3.099241e-01 4.522739e-01 2 203395659 203395780 122 + 2.129 2.177 0.158
ENSG00000138443 E043 0.4407149 0.0229223856 8.093461e-01 8.789284e-01 2 203396785 203396883 99 + 0.187 0.144 -0.454
ENSG00000138443 E044 0.2966881 0.0270571563 3.302910e-01   2 203396884 203396967 84 + 0.187 0.000 -12.644
ENSG00000138443 E045 143.2011476 0.0005573517 3.819023e-02 8.771109e-02 2 203402576 203402705 130 + 2.129 2.194 0.218
ENSG00000138443 E046 93.8568819 0.0003625013 1.587014e-01 2.733973e-01 2 203402706 203402734 29 + 1.951 2.004 0.179
ENSG00000138443 E047 0.1451727 0.0429240360 7.016153e-01   2 203403317 203403361 45 + 0.103 0.000 -11.456
ENSG00000138443 E048 67.9646095 0.0003669391 6.301840e-02 1.317368e-01 2 203411285 203411371 87 + 1.801 1.882 0.273
ENSG00000138443 E049 76.1383524 0.0003841122 5.551754e-02 1.188665e-01 2 203416908 203416913 6 + 1.853 1.932 0.267
ENSG00000138443 E050 184.1422962 0.0002458226 1.885239e-02 4.901098e-02 2 203416914 203417081 168 + 2.240 2.303 0.212
ENSG00000138443 E051 152.8428047 0.0016683237 3.375765e-02 7.926729e-02 2 203427177 203427269 93 + 2.154 2.228 0.246
ENSG00000138443 E052 159.9594503 0.0005345543 8.188193e-03 2.426031e-02 2 203427270 203427495 226 + 2.172 2.251 0.264
ENSG00000138443 E053 872.0403035 0.0009435413 2.249620e-28 3.288454e-26 2 203427496 203430996 3501 + 3.013 2.835 -0.593
ENSG00000138443 E054 49.6600637 0.0149270365 3.872751e-01 5.314258e-01 2 203430997 203431000 4 + 1.676 1.737 0.207
ENSG00000138443 E055 372.1849723 0.0103225800 5.936719e-05 3.283106e-04 2 203431001 203433465 2465 + 2.468 2.671 0.674
ENSG00000138443 E056 1.2532576 0.0454854381 6.222985e-01 7.391246e-01 2 203433466 203436670 3205 + 0.317 0.410 0.542
ENSG00000138443 E057 5.9881818 0.0027796132 8.146296e-03 2.415246e-02 2 203436671 203447728 11058 + 0.971 0.618 -1.407