ENSG00000138442

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000475611 ENSG00000138442 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR12 protein_coding retained_intron 42.92882 22.74003 64.72752 3.162287 3.314311 1.508734 2.436242 1.174176 4.639893 0.1852287 0.5732995 1.9733141 0.05870833 0.05270000 0.07116667 0.01846667 0.443906880 3.60303e-05 FALSE FALSE
ENST00000478869 ENSG00000138442 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR12 protein_coding retained_intron 42.92882 22.74003 64.72752 3.162287 3.314311 1.508734 5.627285 1.328658 10.711110 0.4882687 2.1764893 3.0015953 0.11041250 0.06603333 0.16276667 0.09673333 0.264120523 3.60303e-05 FALSE TRUE
MSTRG.19811.5 ENSG00000138442 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR12 protein_coding   42.92882 22.74003 64.72752 3.162287 3.314311 1.508734 16.721620 12.205673 22.207104 2.5632357 0.2288259 0.8629374 0.43155417 0.52736667 0.34506667 -0.18230000 0.004169354 3.60303e-05 FALSE TRUE
MSTRG.19811.6 ENSG00000138442 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR12 protein_coding   42.92882 22.74003 64.72752 3.162287 3.314311 1.508734 6.338381 2.634561 10.811432 0.4639976 2.9755275 2.0327915 0.12437917 0.11670000 0.16990000 0.05320000 0.754516088 3.60303e-05 FALSE TRUE
MSTRG.19811.7 ENSG00000138442 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR12 protein_coding   42.92882 22.74003 64.72752 3.162287 3.314311 1.508734 7.472390 3.373800 8.676153 0.1547604 2.5945711 1.3600729 0.18329167 0.15333333 0.13320000 -0.02013333 0.826239736 3.60303e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138442 E001 350.0427318 0.0001790636 4.815908e-65 5.811206e-62 2 202874261 202880600 6340 - 2.619 2.232 -1.291
ENSG00000138442 E002 3.2095515 0.0135596644 8.933389e-01 9.358349e-01 2 202880601 202880602 2 - 0.618 0.604 -0.063
ENSG00000138442 E003 5.1354886 0.0059921885 3.159826e-02 7.507048e-02 2 202880603 202880609 7 - 0.660 0.956 1.170
ENSG00000138442 E004 8.0818599 0.0049380199 1.692670e-03 6.259692e-03 2 202880610 202880635 26 - 0.781 1.149 1.375
ENSG00000138442 E005 8.1068640 0.0021557984 1.613404e-04 7.977205e-04 2 202880636 202880642 7 - 0.750 1.179 1.609
ENSG00000138442 E006 246.3873891 0.0029414360 1.714553e-04 8.413419e-04 2 202880643 202880937 295 - 2.323 2.462 0.462
ENSG00000138442 E007 227.8635834 0.0016589602 5.225547e-02 1.131737e-01 2 202882711 202882783 73 - 2.316 2.387 0.235
ENSG00000138442 E008 1.7598514 0.0090431739 6.407900e-01 7.539781e-01 2 202882784 202882855 72 - 0.393 0.479 0.455
ENSG00000138442 E009 0.5964967 0.0202834101 8.656425e-01 9.174558e-01 2 202883473 202883588 116 - 0.212 0.177 -0.325
ENSG00000138442 E010 0.6759915 0.5546012581 9.495494e-01 9.724069e-01 2 202883589 202883608 20 - 0.214 0.182 -0.285
ENSG00000138442 E011 290.5972247 0.0016300099 3.655023e-02 8.462367e-02 2 202883609 202883741 133 - 2.421 2.491 0.232
ENSG00000138442 E012 1.0737433 0.0119544416 4.750138e-01 6.137839e-01 2 202884141 202884197 57 - 0.265 0.400 0.845
ENSG00000138442 E013 177.9246543 0.0002299640 3.946190e-02 9.003261e-02 2 202884198 202884237 40 - 2.211 2.277 0.220
ENSG00000138442 E014 186.5573076 0.0003273837 2.666688e-01 4.049027e-01 2 202884238 202884303 66 - 2.241 2.280 0.131
ENSG00000138442 E015 0.7405235 0.0159092396 6.392586e-01 7.526857e-01 2 202884304 202884394 91 - 0.212 0.302 0.674
ENSG00000138442 E016 276.8073936 0.0001474321 1.905147e-02 4.944780e-02 2 202884395 202884535 141 - 2.403 2.463 0.200
ENSG00000138442 E017 281.3044697 0.0001634066 2.394168e-01 3.734422e-01 2 202892617 202892702 86 - 2.419 2.453 0.114
ENSG00000138442 E018 206.3217954 0.0012117628 2.483913e-01 3.840290e-01 2 202894581 202894626 46 - 2.283 2.324 0.138
ENSG00000138442 E019 19.5826370 0.0009128022 4.730071e-03 1.517781e-02 2 202894627 202894765 139 - 1.359 1.117 -0.854
ENSG00000138442 E020 11.0523452 0.0318592264 2.598839e-01 3.973547e-01 2 202895998 202896064 67 - 1.099 0.937 -0.598
ENSG00000138442 E021 354.8762005 0.0001602664 2.727347e-01 4.116936e-01 2 202896065 202896215 151 - 2.521 2.550 0.097
ENSG00000138442 E022 153.2257492 0.0007858918 6.231472e-01 7.397940e-01 2 202896216 202896219 4 - 2.160 2.183 0.076
ENSG00000138442 E023 297.1439526 0.0010898838 2.255149e-01 3.570179e-01 2 202897300 202897415 116 - 2.441 2.475 0.116
ENSG00000138442 E024 177.0923339 0.0043185441 1.721461e-01 2.909783e-01 2 202899531 202899556 26 - 2.209 2.262 0.178
ENSG00000138442 E025 230.7198738 0.0008740211 3.070498e-01 4.492317e-01 2 202899557 202899637 81 - 2.332 2.366 0.111
ENSG00000138442 E026 215.5166990 0.0002176678 5.765649e-01 7.019630e-01 2 202901025 202901119 95 - 2.308 2.330 0.073
ENSG00000138442 E027 1.4727282 0.0101820487 8.141202e-01 8.822166e-01 2 202901120 202901120 1 - 0.354 0.400 0.263
ENSG00000138442 E028 0.1451727 0.0437368014 1.000000e+00   2 202901209 202901268 60 - 0.083 0.001 -7.305
ENSG00000138442 E029 259.2667334 0.0002452552 2.002674e-02 5.154550e-02 2 202907865 202907959 95 - 2.410 2.361 -0.163
ENSG00000138442 E030 351.1264609 0.0001745665 2.425615e-05 1.476055e-04 2 202911436 202912226 791 - 2.550 2.471 -0.266
ENSG00000138442 E031 0.0000000       2 202925276 202925468 193 -      
ENSG00000138442 E032 0.0000000       2 203014557 203014798 242 -