ENSG00000138434

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320370 ENSG00000138434 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPRID2 protein_coding protein_coding 10.59982 3.838197 15.28924 0.3995285 0.7029163 1.991205 1.3129677 0.0000000 0.9002712 0.000000000 0.11873640 6.508224 0.07712083 0.00000000 0.05846667 0.05846667 4.808918e-06 1.515785e-18 FALSE TRUE
ENST00000409001 ENSG00000138434 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPRID2 protein_coding protein_coding 10.59982 3.838197 15.28924 0.3995285 0.7029163 1.991205 3.6151167 0.6542409 5.0190422 0.237933846 0.39227091 2.920505 0.29764583 0.18123333 0.32963333 0.14840000 3.056223e-01 1.515785e-18 FALSE TRUE
ENST00000431877 ENSG00000138434 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPRID2 protein_coding protein_coding 10.59982 3.838197 15.28924 0.3995285 0.7029163 1.991205 1.9682571 0.0000000 4.8099564 0.000000000 0.44667009 8.912876 0.15141250 0.00000000 0.31556667 0.31556667 1.515785e-18 1.515785e-18 FALSE TRUE
ENST00000451836 ENSG00000138434 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPRID2 protein_coding protein_coding 10.59982 3.838197 15.28924 0.3995285 0.7029163 1.991205 0.2277458 0.8836119 0.2118295 0.475487545 0.07255938 -2.010197 0.05338750 0.20916667 0.01350000 -0.19566667 2.554047e-01 1.515785e-18 FALSE TRUE
ENST00000467172 ENSG00000138434 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPRID2 protein_coding processed_transcript 10.59982 3.838197 15.28924 0.3995285 0.7029163 1.991205 0.1396878 0.2207923 0.0000000 0.220792271 0.00000000 -4.528523 0.04004167 0.06956667 0.00000000 -0.06956667 5.992152e-01 1.515785e-18 FALSE TRUE
ENST00000480753 ENSG00000138434 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPRID2 protein_coding retained_intron 10.59982 3.838197 15.28924 0.3995285 0.7029163 1.991205 1.0249873 0.6200178 1.8397029 0.119169812 0.10606069 1.553829 0.09981667 0.15920000 0.12036667 -0.03883333 3.437312e-01 1.515785e-18 FALSE FALSE
ENST00000491720 ENSG00000138434 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPRID2 protein_coding retained_intron 10.59982 3.838197 15.28924 0.3995285 0.7029163 1.991205 0.9824824 0.1562920 1.3576455 0.009987416 0.20843694 3.039904 0.09192500 0.04183333 0.08906667 0.04723333 1.477055e-01 1.515785e-18 TRUE TRUE
MSTRG.19607.10 ENSG00000138434 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPRID2 protein_coding   10.59982 3.838197 15.28924 0.3995285 0.7029163 1.991205 0.2016922 0.2750908 0.1198042 0.193619438 0.05387545 -1.135085 0.02554583 0.07003333 0.00790000 -0.06213333 3.633164e-01 1.515785e-18 FALSE TRUE
MSTRG.19607.14 ENSG00000138434 HEK293_OSMI2_2hA HEK293_TMG_2hB ITPRID2 protein_coding   10.59982 3.838197 15.28924 0.3995285 0.7029163 1.991205 0.6089594 1.0281516 0.3429234 0.112573165 0.21236932 -1.556590 0.10986250 0.26893333 0.02170000 -0.24723333 8.532323e-03 1.515785e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000138434 E001 0.7448917 0.0558608543 4.941804e-01 6.311542e-01 2 181891730 181891832 103 + 0.223 0.000 -9.690
ENSG00000138434 E002 4.9479529 0.0032597856 1.098647e-01 2.053568e-01 2 181891833 181891954 122 + 0.713 0.411 -1.404
ENSG00000138434 E003 11.8994422 0.0014844896 1.682409e-02 4.454236e-02 2 181891955 181891984 30 + 1.039 0.694 -1.337
ENSG00000138434 E004 39.5585768 0.0133988121 2.188474e-03 7.806289e-03 2 181891985 181892195 211 + 1.529 1.223 -1.065
ENSG00000138434 E005 39.1633422 0.0251949322 3.782785e-02 8.701912e-02 2 181892196 181892277 82 + 1.518 1.294 -0.772
ENSG00000138434 E006 0.6192988 0.0196811987 5.844544e-01 7.083792e-01 2 181892353 181892378 26 + 0.147 0.252 0.966
ENSG00000138434 E007 29.2904191 0.0023212069 2.090781e-03 7.504588e-03 2 181892615 181892631 17 + 1.404 1.107 -1.045
ENSG00000138434 E008 35.7026575 0.0005926435 1.710779e-04 8.396859e-04 2 181892632 181892660 29 + 1.489 1.158 -1.157
ENSG00000138434 E009 30.9819854 0.0008356019 3.428724e-06 2.534577e-05 2 181892661 181893392 732 + 1.309 1.654 1.187
ENSG00000138434 E010 12.3226202 0.0428081655 1.375800e-01 2.447129e-01 2 181893393 181893610 218 + 0.965 1.199 0.848
ENSG00000138434 E011 12.4816123 0.0529382091 3.922335e-01 5.361714e-01 2 181893611 181893745 135 + 0.990 1.131 0.514
ENSG00000138434 E012 28.8070720 0.0009764246 2.286359e-10 3.788871e-09 2 181893746 181894695 950 + 1.241 1.704 1.595
ENSG00000138434 E013 35.5038635 0.0015239211 1.357663e-06 1.095796e-05 2 181896030 181896079 50 + 1.497 1.019 -1.686
ENSG00000138434 E014 40.0821655 0.0005644407 2.434266e-08 2.790707e-07 2 181896908 181896964 57 + 1.551 1.019 -1.871
ENSG00000138434 E015 0.0000000       2 181898859 181898879 21 +      
ENSG00000138434 E016 36.4067114 0.0005773665 1.681244e-05 1.060734e-04 2 181898880 181898919 40 + 1.501 1.108 -1.376
ENSG00000138434 E017 46.0403844 0.0004888152 3.657739e-06 2.686365e-05 2 181899014 181899112 99 + 1.598 1.224 -1.293
ENSG00000138434 E018 34.5940865 0.0006099230 4.326320e-03 1.405846e-02 2 181900696 181900860 165 + 1.464 1.224 -0.835
ENSG00000138434 E019 26.0250881 0.0012731015 6.207631e-03 1.916149e-02 2 181900861 181900904 44 + 1.350 1.080 -0.956
ENSG00000138434 E020 149.0966019 0.0006985957 2.102976e-09 2.932449e-08 2 181901766 181902466 701 + 2.087 1.832 -0.857
ENSG00000138434 E021 49.4899397 0.0004422475 7.199197e-03 2.174220e-02 2 181909899 181909971 73 + 1.611 1.431 -0.615
ENSG00000138434 E022 0.2903454 0.3140091462 1.000000e+00   2 181910505 181910629 125 + 0.103 0.000 -9.887
ENSG00000138434 E023 0.8105550 0.0149674470 7.577271e-01 8.424393e-01 2 181911200 181911233 34 + 0.187 0.252 0.552
ENSG00000138434 E024 47.8712826 0.0049847764 3.355814e-03 1.130904e-02 2 181913845 181913933 89 + 1.603 1.376 -0.780
ENSG00000138434 E025 80.5603420 0.0049054221 1.545112e-03 5.781718e-03 2 181915216 181915414 199 + 1.820 1.622 -0.671
ENSG00000138434 E026 139.3194137 0.0190782080 5.133653e-02 1.115277e-01 2 181915415 181915921 507 + 2.047 1.908 -0.464
ENSG00000138434 E027 116.7911695 0.0002852329 4.325769e-03 1.405724e-02 2 181915922 181916427 506 + 1.967 1.852 -0.388
ENSG00000138434 E028 8.4860079 0.0041470051 3.524770e-01 4.967285e-01 2 181916428 181916721 294 + 0.888 0.758 -0.509
ENSG00000138434 E029 11.0335887 0.0015960705 3.109196e-01 4.533600e-01 2 181916722 181917005 284 + 0.989 0.863 -0.473
ENSG00000138434 E030 25.4701904 0.0141306596 4.906146e-01 6.279632e-01 2 181917006 181918322 1317 + 1.312 1.246 -0.234
ENSG00000138434 E031 7.1035093 0.0381983470 4.521341e-01 5.930176e-01 2 181918323 181918470 148 + 0.824 0.692 -0.529
ENSG00000138434 E032 4.8583389 0.0034647063 9.285233e-01 9.590284e-01 2 181918471 181918597 127 + 0.666 0.693 0.116
ENSG00000138434 E033 34.3840532 0.0006186729 5.217753e-01 6.556610e-01 2 181918598 181918675 78 + 1.415 1.479 0.221
ENSG00000138434 E034 39.5271243 0.0005285545 3.751957e-01 5.195998e-01 2 181918755 181918860 106 + 1.474 1.552 0.268
ENSG00000138434 E035 26.3994057 0.0007396969 2.726784e-01 4.116388e-01 2 181918861 181918882 22 + 1.297 1.405 0.375
ENSG00000138434 E036 47.7592867 0.0005001388 8.936000e-02 1.741540e-01 2 181919296 181919446 151 + 1.546 1.669 0.419
ENSG00000138434 E037 17.3254917 0.0010313123 6.346237e-01 7.490470e-01 2 181920597 181920605 9 + 1.139 1.203 0.228
ENSG00000138434 E038 27.5622524 0.0007089602 5.724766e-01 6.985927e-01 2 181920606 181920650 45 + 1.329 1.391 0.218
ENSG00000138434 E039 20.0228758 0.0009580689 5.844698e-01 7.083792e-01 2 181920651 181920662 12 + 1.195 1.263 0.241
ENSG00000138434 E040 142.8784390 0.0075484800 9.012409e-03 2.630857e-02 2 181921948 181922412 465 + 2.004 2.155 0.506
ENSG00000138434 E041 51.4724492 0.0004905065 6.559532e-06 4.546126e-05 2 181928161 181928199 39 + 1.538 1.812 0.930
ENSG00000138434 E042 60.2870336 0.0004426142 1.750880e-04 8.573249e-04 2 181928200 181928278 79 + 1.618 1.837 0.743
ENSG00000138434 E043 213.0359827 0.0024302341 1.540878e-31 2.867531e-29 2 181929561 181930738 1178 + 2.112 2.508 1.321